Predictive Value of Low BMD for 1‐Year Fracture Outcomes Is Similar for Postmenopausal Women Ages 50‐64 and 65 and Older: Results From the National Osteoporosis Risk Assessment (NORA)
The relationship of low bone mass and fracture in younger postmenopausal women has not been extensively studied. In a large cohort of postmenopausal women ≥50 years of age, we found the relationship of BMD measured at peripheral sites and subsequent 1‐year fracture risk to be similar between women...
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| Veröffentlicht in: | Journal of bone and mineral research 2004-08, Vol.19 (8), p.1215-1220 |
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| creator | Siris, Ethel S Brenneman, Susan K Miller, Paul D Barrett‐Connor, Elizabeth Chen, Ya‐Ting Sherwood, Louis M Abbott, Thomas A |
| description | The relationship of low bone mass and fracture in younger postmenopausal women has not been extensively studied. In a large cohort of postmenopausal women ≥50 years of age, we found the relationship of BMD measured at peripheral sites and subsequent 1‐year fracture risk to be similar between women |
| doi_str_mv | 10.1359/JBMR.040508 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66668912</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66668912</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4333-25847002e6eb753286ca3e4e0cc7cad92b20b560e9656a5cdef0aea5b8c6fee3</originalsourceid><addsrcrecordid>eNqF0c1u1DAQB_AIgehSOHFHvoBAKGUcx47DbVsoFG2baqlAnCKvMwFDEi-ehKo3HoH34W14ErzdlXoDX8aSf_77Y5LkIYcDLmT54t3h6fIAcpCgbyUzLjOR5krz28kMtM5TyAXfS-4RfQUAJZW6m-xtEAcoZsnv84CNs6P7geyD6SZkvmULf8kOT1-x1gfG__z89QlNYMfB2HEKyKpptL5HYifE3rvedXFxI889jT0Ofm0mMh37GM3A5p8jlBBDVM7M0DAlr0vVNRhesiXS1I0Uw33Pxi_Izszo_BC3VzSiX_vgyRFbOvrG5kRIFENH9vSsWs6f3U_utKYjfLCr-8nF8euLo7fponpzcjRfpDYXQqSZ1HkBkKHCVSFFppU1AnMEawtrmjJbZbCSCrCMv2OkbbAFg0autFUtothPnmxj18F_n5DGundksevMgH6iWsWhS579F3INQgtdRPh8C218HgVs63VwvQlXNYd609N609N629OoH-1ip1WPzY3dNTGCxztgyJquDWawjm6cAigFF9EVW3fpOrz615nXc6kk8BLipcVfjkO7Pg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18038387</pqid></control><display><type>article</type><title>Predictive Value of Low BMD for 1‐Year Fracture Outcomes Is Similar for Postmenopausal Women Ages 50‐64 and 65 and Older: Results From the National Osteoporosis Risk Assessment (NORA)</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Siris, Ethel S ; Brenneman, Susan K ; Miller, Paul D ; Barrett‐Connor, Elizabeth ; Chen, Ya‐Ting ; Sherwood, Louis M ; Abbott, Thomas A</creator><creatorcontrib>Siris, Ethel S ; Brenneman, Susan K ; Miller, Paul D ; Barrett‐Connor, Elizabeth ; Chen, Ya‐Ting ; Sherwood, Louis M ; Abbott, Thomas A</creatorcontrib><description>The relationship of low bone mass and fracture in younger postmenopausal women has not been extensively studied. In a large cohort of postmenopausal women ≥50 years of age, we found the relationship of BMD measured at peripheral sites and subsequent 1‐year fracture risk to be similar between women <65 and those ≥65 years of age.
Introduction: Low bone mass and fractures are prevalent in older postmenopausal women. However, the frequency of low bone mass and fracture in younger postmenopausal women has not been studied extensively. There are very limited data regarding the association between BMD measurements and fractures in postmenopausal women who are between the ages of 50 and 64.
Materials and Methods: In the National Osteoporosis Risk Assessment (NORA) we studied the frequency of low bone mass and its association with fracture in women 50‐64 years of age in comparison with women ≥65 of age. NORA enrolled 200,160 postmenopausal women ≥50 years of age who had no prior diagnosis of osteoporosis. Baseline BMD was measured at the heel, forearm, or finger. A 1‐year follow‐up survey requesting incident fractures since baseline was completed by 163,935 women, 87,594 (53%) of whom were 50‐64 years of age. The association between BMD and fracture was assessed using logistic regression, adjusted for important covariates.
Results: Thirty‐one percent of women 50‐64 years of age had low bone mass (T scores ≤ −1.0) compared to 62% of women ≥65 years of age. During the first year of follow‐up, 2440 women reported fractures of wrist/forearm, rib, spine, or hip, including 440 hip fractures. Nine hundred four women 50‐64 years of age reported fractures, including 86 hip fractures, accounting for 37% of fractures and 20% of hip fractures reported in the entire NORA cohort. Relative risk for osteoporotic fracture was 1.5 for each SD decrease in BMD for both the younger and older groups of women.
Conclusion: Low BMD in younger postmenopausal women 50‐64 years of age showed a 1‐year relative risk of fracture similar to that found in women ≥65 years of age.</description><identifier>ISSN: 0884-0431</identifier><identifier>EISSN: 1523-4681</identifier><identifier>DOI: 10.1359/JBMR.040508</identifier><identifier>PMID: 15231007</identifier><identifier>CODEN: JBMREJ</identifier><language>eng</language><publisher>Washington, DC: John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Biological and medical sciences ; BMD ; Bone Density ; Bones of Upper Extremity - chemistry ; Calcaneus - chemistry ; Female ; Forearm Injuries - epidemiology ; fracture risk ; Fractures, Bone - epidemiology ; Fractures, Bone - ethnology ; Fundamental and applied biological sciences. Psychology ; Hip Fractures - epidemiology ; Humans ; Medical History Taking ; Middle Aged ; Multivariate Analysis ; osteoporosis ; Postmenopause ; Prospective Studies ; Rib Fractures - epidemiology ; Risk Assessment ; Skeleton and joints ; Spinal Fractures - epidemiology ; Surveys and Questionnaires ; United States - epidemiology ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of bone and mineral research, 2004-08, Vol.19 (8), p.1215-1220</ispartof><rights>Copyright © 2004 ASBMR</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4333-25847002e6eb753286ca3e4e0cc7cad92b20b560e9656a5cdef0aea5b8c6fee3</citedby><cites>FETCH-LOGICAL-c4333-25847002e6eb753286ca3e4e0cc7cad92b20b560e9656a5cdef0aea5b8c6fee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1359%2FJBMR.040508$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1359%2FJBMR.040508$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16009313$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15231007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siris, Ethel S</creatorcontrib><creatorcontrib>Brenneman, Susan K</creatorcontrib><creatorcontrib>Miller, Paul D</creatorcontrib><creatorcontrib>Barrett‐Connor, Elizabeth</creatorcontrib><creatorcontrib>Chen, Ya‐Ting</creatorcontrib><creatorcontrib>Sherwood, Louis M</creatorcontrib><creatorcontrib>Abbott, Thomas A</creatorcontrib><title>Predictive Value of Low BMD for 1‐Year Fracture Outcomes Is Similar for Postmenopausal Women Ages 50‐64 and 65 and Older: Results From the National Osteoporosis Risk Assessment (NORA)</title><title>Journal of bone and mineral research</title><addtitle>J Bone Miner Res</addtitle><description>The relationship of low bone mass and fracture in younger postmenopausal women has not been extensively studied. In a large cohort of postmenopausal women ≥50 years of age, we found the relationship of BMD measured at peripheral sites and subsequent 1‐year fracture risk to be similar between women <65 and those ≥65 years of age.
Introduction: Low bone mass and fractures are prevalent in older postmenopausal women. However, the frequency of low bone mass and fracture in younger postmenopausal women has not been studied extensively. There are very limited data regarding the association between BMD measurements and fractures in postmenopausal women who are between the ages of 50 and 64.
Materials and Methods: In the National Osteoporosis Risk Assessment (NORA) we studied the frequency of low bone mass and its association with fracture in women 50‐64 years of age in comparison with women ≥65 of age. NORA enrolled 200,160 postmenopausal women ≥50 years of age who had no prior diagnosis of osteoporosis. Baseline BMD was measured at the heel, forearm, or finger. A 1‐year follow‐up survey requesting incident fractures since baseline was completed by 163,935 women, 87,594 (53%) of whom were 50‐64 years of age. The association between BMD and fracture was assessed using logistic regression, adjusted for important covariates.
Results: Thirty‐one percent of women 50‐64 years of age had low bone mass (T scores ≤ −1.0) compared to 62% of women ≥65 years of age. During the first year of follow‐up, 2440 women reported fractures of wrist/forearm, rib, spine, or hip, including 440 hip fractures. Nine hundred four women 50‐64 years of age reported fractures, including 86 hip fractures, accounting for 37% of fractures and 20% of hip fractures reported in the entire NORA cohort. Relative risk for osteoporotic fracture was 1.5 for each SD decrease in BMD for both the younger and older groups of women.
Conclusion: Low BMD in younger postmenopausal women 50‐64 years of age showed a 1‐year relative risk of fracture similar to that found in women ≥65 years of age.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>BMD</subject><subject>Bone Density</subject><subject>Bones of Upper Extremity - chemistry</subject><subject>Calcaneus - chemistry</subject><subject>Female</subject><subject>Forearm Injuries - epidemiology</subject><subject>fracture risk</subject><subject>Fractures, Bone - epidemiology</subject><subject>Fractures, Bone - ethnology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hip Fractures - epidemiology</subject><subject>Humans</subject><subject>Medical History Taking</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>osteoporosis</subject><subject>Postmenopause</subject><subject>Prospective Studies</subject><subject>Rib Fractures - epidemiology</subject><subject>Risk Assessment</subject><subject>Skeleton and joints</subject><subject>Spinal Fractures - epidemiology</subject><subject>Surveys and Questionnaires</subject><subject>United States - epidemiology</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0884-0431</issn><issn>1523-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1u1DAQB_AIgehSOHFHvoBAKGUcx47DbVsoFG2baqlAnCKvMwFDEi-ehKo3HoH34W14ErzdlXoDX8aSf_77Y5LkIYcDLmT54t3h6fIAcpCgbyUzLjOR5krz28kMtM5TyAXfS-4RfQUAJZW6m-xtEAcoZsnv84CNs6P7geyD6SZkvmULf8kOT1-x1gfG__z89QlNYMfB2HEKyKpptL5HYifE3rvedXFxI889jT0Ofm0mMh37GM3A5p8jlBBDVM7M0DAlr0vVNRhesiXS1I0Uw33Pxi_Izszo_BC3VzSiX_vgyRFbOvrG5kRIFENH9vSsWs6f3U_utKYjfLCr-8nF8euLo7fponpzcjRfpDYXQqSZ1HkBkKHCVSFFppU1AnMEawtrmjJbZbCSCrCMv2OkbbAFg0autFUtothPnmxj18F_n5DGundksevMgH6iWsWhS579F3INQgtdRPh8C218HgVs63VwvQlXNYd609N609N629OoH-1ip1WPzY3dNTGCxztgyJquDWawjm6cAigFF9EVW3fpOrz615nXc6kk8BLipcVfjkO7Pg</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Siris, Ethel S</creator><creator>Brenneman, Susan K</creator><creator>Miller, Paul D</creator><creator>Barrett‐Connor, Elizabeth</creator><creator>Chen, Ya‐Ting</creator><creator>Sherwood, Louis M</creator><creator>Abbott, Thomas A</creator><general>John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)</general><general>American Society for Bone and Mineral Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>200408</creationdate><title>Predictive Value of Low BMD for 1‐Year Fracture Outcomes Is Similar for Postmenopausal Women Ages 50‐64 and 65 and Older: Results From the National Osteoporosis Risk Assessment (NORA)</title><author>Siris, Ethel S ; Brenneman, Susan K ; Miller, Paul D ; Barrett‐Connor, Elizabeth ; Chen, Ya‐Ting ; Sherwood, Louis M ; Abbott, Thomas A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4333-25847002e6eb753286ca3e4e0cc7cad92b20b560e9656a5cdef0aea5b8c6fee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>BMD</topic><topic>Bone Density</topic><topic>Bones of Upper Extremity - chemistry</topic><topic>Calcaneus - chemistry</topic><topic>Female</topic><topic>Forearm Injuries - epidemiology</topic><topic>fracture risk</topic><topic>Fractures, Bone - epidemiology</topic><topic>Fractures, Bone - ethnology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hip Fractures - epidemiology</topic><topic>Humans</topic><topic>Medical History Taking</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>osteoporosis</topic><topic>Postmenopause</topic><topic>Prospective Studies</topic><topic>Rib Fractures - epidemiology</topic><topic>Risk Assessment</topic><topic>Skeleton and joints</topic><topic>Spinal Fractures - epidemiology</topic><topic>Surveys and Questionnaires</topic><topic>United States - epidemiology</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siris, Ethel S</creatorcontrib><creatorcontrib>Brenneman, Susan K</creatorcontrib><creatorcontrib>Miller, Paul D</creatorcontrib><creatorcontrib>Barrett‐Connor, Elizabeth</creatorcontrib><creatorcontrib>Chen, Ya‐Ting</creatorcontrib><creatorcontrib>Sherwood, Louis M</creatorcontrib><creatorcontrib>Abbott, Thomas A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siris, Ethel S</au><au>Brenneman, Susan K</au><au>Miller, Paul D</au><au>Barrett‐Connor, Elizabeth</au><au>Chen, Ya‐Ting</au><au>Sherwood, Louis M</au><au>Abbott, Thomas A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Value of Low BMD for 1‐Year Fracture Outcomes Is Similar for Postmenopausal Women Ages 50‐64 and 65 and Older: Results From the National Osteoporosis Risk Assessment (NORA)</atitle><jtitle>Journal of bone and mineral research</jtitle><addtitle>J Bone Miner Res</addtitle><date>2004-08</date><risdate>2004</risdate><volume>19</volume><issue>8</issue><spage>1215</spage><epage>1220</epage><pages>1215-1220</pages><issn>0884-0431</issn><eissn>1523-4681</eissn><coden>JBMREJ</coden><abstract>The relationship of low bone mass and fracture in younger postmenopausal women has not been extensively studied. In a large cohort of postmenopausal women ≥50 years of age, we found the relationship of BMD measured at peripheral sites and subsequent 1‐year fracture risk to be similar between women <65 and those ≥65 years of age.
Introduction: Low bone mass and fractures are prevalent in older postmenopausal women. However, the frequency of low bone mass and fracture in younger postmenopausal women has not been studied extensively. There are very limited data regarding the association between BMD measurements and fractures in postmenopausal women who are between the ages of 50 and 64.
Materials and Methods: In the National Osteoporosis Risk Assessment (NORA) we studied the frequency of low bone mass and its association with fracture in women 50‐64 years of age in comparison with women ≥65 of age. NORA enrolled 200,160 postmenopausal women ≥50 years of age who had no prior diagnosis of osteoporosis. Baseline BMD was measured at the heel, forearm, or finger. A 1‐year follow‐up survey requesting incident fractures since baseline was completed by 163,935 women, 87,594 (53%) of whom were 50‐64 years of age. The association between BMD and fracture was assessed using logistic regression, adjusted for important covariates.
Results: Thirty‐one percent of women 50‐64 years of age had low bone mass (T scores ≤ −1.0) compared to 62% of women ≥65 years of age. During the first year of follow‐up, 2440 women reported fractures of wrist/forearm, rib, spine, or hip, including 440 hip fractures. Nine hundred four women 50‐64 years of age reported fractures, including 86 hip fractures, accounting for 37% of fractures and 20% of hip fractures reported in the entire NORA cohort. Relative risk for osteoporotic fracture was 1.5 for each SD decrease in BMD for both the younger and older groups of women.
Conclusion: Low BMD in younger postmenopausal women 50‐64 years of age showed a 1‐year relative risk of fracture similar to that found in women ≥65 years of age.</abstract><cop>Washington, DC</cop><pub>John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)</pub><pmid>15231007</pmid><doi>10.1359/JBMR.040508</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Age Factors Aged Aged, 80 and over Biological and medical sciences BMD Bone Density Bones of Upper Extremity - chemistry Calcaneus - chemistry Female Forearm Injuries - epidemiology fracture risk Fractures, Bone - epidemiology Fractures, Bone - ethnology Fundamental and applied biological sciences. Psychology Hip Fractures - epidemiology Humans Medical History Taking Middle Aged Multivariate Analysis osteoporosis Postmenopause Prospective Studies Rib Fractures - epidemiology Risk Assessment Skeleton and joints Spinal Fractures - epidemiology Surveys and Questionnaires United States - epidemiology Vertebrates: osteoarticular system, musculoskeletal system |
| title | Predictive Value of Low BMD for 1‐Year Fracture Outcomes Is Similar for Postmenopausal Women Ages 50‐64 and 65 and Older: Results From the National Osteoporosis Risk Assessment (NORA) |
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