Magnetic Resonance Imaging Surrogates of Multiple Sclerosis Pathology and Their Relationship to Central Nervous System Atrophy
ABSTRACT This article focuses on the various magnetic resonance imaging metrics currently used in multiple sclerosis and discusses how they relate to central nervous system atrophy. The authors discuss the significance of T2 lesion burden, gray matter damage, T1 hypointense lesions (black holes), co...
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| Veröffentlicht in: | Journal of neuroimaging 2004-07, Vol.14 (s3), p.46S-53S |
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| container_end_page | 53S |
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| container_issue | s3 |
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| container_title | Journal of neuroimaging |
| container_volume | 14 |
| creator | Meier, Dominik S. Weiner, Howard L. Khoury, Samia J. Guttmann, Charles R. G. |
| description | ABSTRACT
This article focuses on the various magnetic resonance imaging metrics currently used in multiple sclerosis and discusses how they relate to central nervous system atrophy. The authors discuss the significance of T2 lesion burden, gray matter damage, T1 hypointense lesions (black holes), contrast‐enhanced lesions, magnetization transfer imaging, diffusion imaging, and magnetic resonance spectroscopy. These magnetic resonance imaging surrogates exhibit different sensitivities for each of the underlying pathogenic processes of multiple sclerosis. By exploiting the complementary nature and varying sensitivities of these magnetic resonance imaging surrogates, it is possible to create a more comprehensive picture of the degenerative process of multiple sclerosis. |
| doi_str_mv | 10.1111/j.1552-6569.2004.tb00278.x |
| format | Article |
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This article focuses on the various magnetic resonance imaging metrics currently used in multiple sclerosis and discusses how they relate to central nervous system atrophy. The authors discuss the significance of T2 lesion burden, gray matter damage, T1 hypointense lesions (black holes), contrast‐enhanced lesions, magnetization transfer imaging, diffusion imaging, and magnetic resonance spectroscopy. These magnetic resonance imaging surrogates exhibit different sensitivities for each of the underlying pathogenic processes of multiple sclerosis. By exploiting the complementary nature and varying sensitivities of these magnetic resonance imaging surrogates, it is possible to create a more comprehensive picture of the degenerative process of multiple sclerosis.</description><identifier>ISSN: 1051-2284</identifier><identifier>EISSN: 1552-6569</identifier><identifier>DOI: 10.1111/j.1552-6569.2004.tb00278.x</identifier><identifier>PMID: 15228759</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>atrophy ; Atrophy - pathology ; Central Nervous System - pathology ; Humans ; magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Spectroscopy ; Multiple sclerosis ; Multiple Sclerosis - pathology ; neurodegeneration</subject><ispartof>Journal of neuroimaging, 2004-07, Vol.14 (s3), p.46S-53S</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340S-ece11750efbb9dcadd9fa89ccbdf824bf8e28dc1e6f7bc078229aae52b056e663</citedby><cites>FETCH-LOGICAL-c340S-ece11750efbb9dcadd9fa89ccbdf824bf8e28dc1e6f7bc078229aae52b056e663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1552-6569.2004.tb00278.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1552-6569.2004.tb00278.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15228759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meier, Dominik S.</creatorcontrib><creatorcontrib>Weiner, Howard L.</creatorcontrib><creatorcontrib>Khoury, Samia J.</creatorcontrib><creatorcontrib>Guttmann, Charles R. G.</creatorcontrib><title>Magnetic Resonance Imaging Surrogates of Multiple Sclerosis Pathology and Their Relationship to Central Nervous System Atrophy</title><title>Journal of neuroimaging</title><addtitle>J Neuroimaging</addtitle><description>ABSTRACT
This article focuses on the various magnetic resonance imaging metrics currently used in multiple sclerosis and discusses how they relate to central nervous system atrophy. The authors discuss the significance of T2 lesion burden, gray matter damage, T1 hypointense lesions (black holes), contrast‐enhanced lesions, magnetization transfer imaging, diffusion imaging, and magnetic resonance spectroscopy. These magnetic resonance imaging surrogates exhibit different sensitivities for each of the underlying pathogenic processes of multiple sclerosis. By exploiting the complementary nature and varying sensitivities of these magnetic resonance imaging surrogates, it is possible to create a more comprehensive picture of the degenerative process of multiple sclerosis.</description><subject>atrophy</subject><subject>Atrophy - pathology</subject><subject>Central Nervous System - pathology</subject><subject>Humans</subject><subject>magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - pathology</subject><subject>neurodegeneration</subject><issn>1051-2284</issn><issn>1552-6569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1u1DAURiMEoqXwCshiwS7BduL8sECqImiL2rQiRbCzHOcm4yGJU9uhkw3PjkczKmvuxpb93XPtEwTvCI6Irw_biDBGw5SlRUQxTiLXYEyzPNo9C06frp77PWYkpDRPToJX1m59iCQ0fhmcEOZPM1acBn9uRD-BUxJ9A6snMUlAV6Po1dSjejFG98KBRbpDN8vg1DwAquUARltl0Z1wGz3ofkViatH9BpTxmEE4pSe7UTNyGpUwOSMGVIH5rReL6tU6GNG5M3rerK-DF50YLLw5rmfB9y-f78vL8Pr24qo8vw5lnOA6BAmEZAxD1zRFK0XbFp3ICymbtstp0nQ50LyVBNIuayTOckoLIYDRBrMU0jQ-C94fuLPRDwtYx0dlJQyDmMC_iqe-srxgPvjxEJT-i9ZAx2ejRmFWTjDf2-dbvlfM94r53j4_2uc73_z2OGVpRmj_tR51-8CnQ-BRDbD-B5p_va2StPaA8ABQ3uLuCSDML55mccb4j-qCV6Qqi_In5XfxX1coqDQ</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Meier, Dominik S.</creator><creator>Weiner, Howard L.</creator><creator>Khoury, Samia J.</creator><creator>Guttmann, Charles R. G.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200407</creationdate><title>Magnetic Resonance Imaging Surrogates of Multiple Sclerosis Pathology and Their Relationship to Central Nervous System Atrophy</title><author>Meier, Dominik S. ; Weiner, Howard L. ; Khoury, Samia J. ; Guttmann, Charles R. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340S-ece11750efbb9dcadd9fa89ccbdf824bf8e28dc1e6f7bc078229aae52b056e663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>atrophy</topic><topic>Atrophy - pathology</topic><topic>Central Nervous System - pathology</topic><topic>Humans</topic><topic>magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - pathology</topic><topic>neurodegeneration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meier, Dominik S.</creatorcontrib><creatorcontrib>Weiner, Howard L.</creatorcontrib><creatorcontrib>Khoury, Samia J.</creatorcontrib><creatorcontrib>Guttmann, Charles R. G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meier, Dominik S.</au><au>Weiner, Howard L.</au><au>Khoury, Samia J.</au><au>Guttmann, Charles R. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic Resonance Imaging Surrogates of Multiple Sclerosis Pathology and Their Relationship to Central Nervous System Atrophy</atitle><jtitle>Journal of neuroimaging</jtitle><addtitle>J Neuroimaging</addtitle><date>2004-07</date><risdate>2004</risdate><volume>14</volume><issue>s3</issue><spage>46S</spage><epage>53S</epage><pages>46S-53S</pages><issn>1051-2284</issn><eissn>1552-6569</eissn><abstract>ABSTRACT
This article focuses on the various magnetic resonance imaging metrics currently used in multiple sclerosis and discusses how they relate to central nervous system atrophy. The authors discuss the significance of T2 lesion burden, gray matter damage, T1 hypointense lesions (black holes), contrast‐enhanced lesions, magnetization transfer imaging, diffusion imaging, and magnetic resonance spectroscopy. These magnetic resonance imaging surrogates exhibit different sensitivities for each of the underlying pathogenic processes of multiple sclerosis. By exploiting the complementary nature and varying sensitivities of these magnetic resonance imaging surrogates, it is possible to create a more comprehensive picture of the degenerative process of multiple sclerosis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15228759</pmid><doi>10.1111/j.1552-6569.2004.tb00278.x</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | atrophy Atrophy - pathology Central Nervous System - pathology Humans magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy Multiple sclerosis Multiple Sclerosis - pathology neurodegeneration |
| title | Magnetic Resonance Imaging Surrogates of Multiple Sclerosis Pathology and Their Relationship to Central Nervous System Atrophy |
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