Spatiotemporal regulation of endothelin receptor-B by SOX10 in neural crest-derived enteric neuron precursors

Hirschsprung disease (HSCR) is a multigenic, congenital disorder that affects 1 in 5,000 newborns and is characterized by the absence of neural crest-derived enteric ganglia in the colon. One of the primary genes affected in HSCR encodes the G protein-coupled endothelin receptor-B (EDNRB). The expre...

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Veröffentlicht in:	Nature genetics 2004-07, Vol.36 (7), p.732-737
Hauptverfasser:	Shin, Myung K, Zhu, Lei, Lee, Hyung-Ok, Jordan, ChaRandle S, Cantrell, V Ashley, Southard-Smith, E Michelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell receptors Cell structures and functions Cloning Complications and side effects Diagnosis Enhancer Elements, Genetic Enteric Nervous System - physiology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation - physiology Gene Function Gene mutations Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Health aspects High Mobility Group Proteins - physiology Hirschsprung's disease Human Genetics letter Mice Mice, Transgenic Miscellaneous Molecular and cellular biology Molecular Sequence Data Mutation Neoplasm Proteins - physiology Receptors, Endothelin - genetics Risk factors Sequence Homology, Nucleic Acid SOXE Transcription Factors Transcription Factors
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