Which circulating level of 25-hydroxyvitamin D is appropriate?

Moderate Vitamin D deficiency causes secondary hyperparathyroidism and bone loss, leading to osteoporosis and fractures. Controversy exists which circulating level of 25-hydroxyvitamin D (25OH)D is appropriate. The high incidence of hip fractures at northern latitudes suggest a relationship with Vit...

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Veröffentlicht in:Journal of steroid biochemistry and molecular biology 2004-05, Vol.89 (1-5), p.611-614
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description Moderate Vitamin D deficiency causes secondary hyperparathyroidism and bone loss, leading to osteoporosis and fractures. Controversy exists which circulating level of 25-hydroxyvitamin D (25OH)D is appropriate. The high incidence of hip fractures at northern latitudes suggest a relationship with Vitamin D deficiency. However, international studies show lower serum 25(OH)D levels in southern than in northern Europe. Serum 25(OH)D was not a risk factor for hip fractures in several epidemiological studies. The required serum 25(OH)D is usually established by assessing the point where serum parathyroid hormone (PTH) starts to rise. This point varied in several studies between 30 and 78 nmol/l. However, interlaboratory variation may also influence the apparent required serum 25(OH)D level. Dietary calcium intake influences serum PTH and serum PTH may influence the turnover of Vitamin D metabolites. A low calcium intake causes an increase of serum PTH and serum 1,25(OH)2D thereby decreasing the half life of serum 25(OH)D. While a low calcium intake may aggravate Vitamin D deficiency, a high calcium intake may have a Vitamin D sparing effect. With current knowledge, a global estimate for the appropriate serum 25(OH)D is 50 nmol/l.
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subjects Biological and medical sciences
Calcium - administration & dosage
Calcium intake
Classification of Vitamin D status
Fundamental and applied biological sciences. Psychology
Hip Fractures - epidemiology
Hip Fractures - etiology
Humans
Medical sciences
Metabolic diseases
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Risk Factors
Threshold serum 25(OH)D
Vertebrates: endocrinology
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D deficiency
Vitamin D Deficiency - complications
Vitamin D Deficiency - epidemiology
Vitamin D replete states
title Which circulating level of 25-hydroxyvitamin D is appropriate?
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