Evaluation of the expression of transcriptional factor NF-kappaB induced by phytic acid in colon cancer cells

Over the last years phytic acid, a hexaphosphorylated inositol (IP6) has attracted particular attention due to its anti-cancer activity, however, the molecular mechanisms of its action have not been elucidated, as yet. The aim of this study was to evaluate the influence of phytic acid on the express...

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Veröffentlicht in:	Acta Poloniae pharmaceutica 2008-11, Vol.65 (6), p.697-702
Hauptverfasser:	Kapral, Małgorzata, Parfiniewicz, Beata, Strzałka-Mrozik, Barbara, Zachacz, Agnieszka, Weglarz, Ludmiła
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Caco-2 Cells Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Dose-Response Relationship, Drug Gene Expression Regulation, Neoplastic - drug effects Humans I-kappa B Proteins - drug effects I-kappa B Proteins - genetics NF-kappa B p50 Subunit - drug effects NF-kappa B p50 Subunit - genetics NF-KappaB Inhibitor alpha Phytic Acid - administration & dosage Phytic Acid - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - drug effects RNA, Messenger - metabolism Time Factors Transcription Factor RelA - drug effects Transcription Factor RelA - genetics Transcription, Genetic
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