Deep sinus aspergillosis in a liver transplant recipient successfully treated with a combination of caspofungin and voriconazole
: We describe the rare case of a diabetic patient who was successfully treated for cytomegalovirus viremia and leishmaniasis following liver transplantation for hepatitis C virus‐related cirrhosis, but also developed invasive sinus Aspergillus infection, while still on liposomal amphotericin B (AmBi...
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| Veröffentlicht in: | Transplant infectious disease 2004-03, Vol.6 (1), p.37-40 |
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| container_title | Transplant infectious disease |
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| creator | Tsiodras, S. Zafiropoulou, R. Giotakis, J. Imbrios, G. Antoniades, A. Manesis, E.K. |
| description | : We describe the rare case of a diabetic patient who was successfully treated for cytomegalovirus viremia and leishmaniasis following liver transplantation for hepatitis C virus‐related cirrhosis, but also developed invasive sinus Aspergillus infection, while still on liposomal amphotericin B (AmBisome). The patient refused radical surgery including eye enucleation, and received a combination of intravenous caspofungin and voriconazole, along with repeated, conservative, local surgical debridement. At follow‐up, 15 months after the onset of sinusitis, the patient remains culture‐negative, fully active, and without evidence of local recurrence. |
| doi_str_mv | 10.1111/j.1399-3062.2004.00039.x |
| format | Article |
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The patient refused radical surgery including eye enucleation, and received a combination of intravenous caspofungin and voriconazole, along with repeated, conservative, local surgical debridement. 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The patient refused radical surgery including eye enucleation, and received a combination of intravenous caspofungin and voriconazole, along with repeated, conservative, local surgical debridement. At follow‐up, 15 months after the onset of sinusitis, the patient remains culture‐negative, fully active, and without evidence of local recurrence.</description><subject>Adult</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Aspergillosis - drug therapy</subject><subject>Aspergillosis - microbiology</subject><subject>Aspergillus</subject><subject>caspofungin</subject><subject>combination treatment</subject><subject>Cytomegalovirus</subject><subject>Echinocandins</subject><subject>Female</subject><subject>Humans</subject><subject>invasive aspergillosis</subject><subject>leishmaniasis</subject><subject>Lipopeptides</subject><subject>liver transplantation</subject><subject>Liver Transplantation - adverse effects</subject><subject>Peptides - therapeutic use</subject><subject>Peptides, Cyclic</subject><subject>Pyrimidines - therapeutic use</subject><subject>Sinusitis - drug therapy</subject><subject>Sinusitis - microbiology</subject><subject>Treatment Outcome</subject><subject>Triazoles - therapeutic use</subject><subject>Voriconazole</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9rFTEUxYMotla_gmTlbsb8mcmbgBtpa1souKnrkGRuah55yZjMtH2u_Ohm-h661EsgB_I75xIOQpiSltb5uG0pl7LhRLCWEdK1hBAu26cX6PTPw8tnPTSMbfgJelPKlhC6kZ18jU5oz1g94hT9ugCYcPFxKViXCfK9DyEVX7CPWOPgHyDjOetYpqDjjDNYP3moqizWQiluCWFfCdAzjPjRz9-rzaad8VHPPkWcHLY1Obkl3q-ZccQPKXubov6ZArxFr5wOBd4d7zP07cvl3fl1c_v16ub8821jOSWy0XIACgOVFHqnyTgIY7QlQvR8HF0vzMZ0YyeJZRQMJ9pxI4wenJa041oDP0MfDrlTTj8WKLPa-WIh1F9BWooSdXpB5D9BRgZOWb-CwwG0OZWSwakp-53Oe0WJWmtSW7W2odY21FqTeq5JPVXr--OOxexg_Gs89lKBTwfg0QfY_3ewuru5qIL_BiGmpJ0</recordid><startdate>200403</startdate><enddate>200403</enddate><creator>Tsiodras, S.</creator><creator>Zafiropoulou, R.</creator><creator>Giotakis, J.</creator><creator>Imbrios, G.</creator><creator>Antoniades, A.</creator><creator>Manesis, E.K.</creator><general>Munksgaard International Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200403</creationdate><title>Deep sinus aspergillosis in a liver transplant recipient successfully treated with a combination of caspofungin and voriconazole</title><author>Tsiodras, S. ; 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| ispartof | Transplant infectious disease, 2004-03, Vol.6 (1), p.37-40 |
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| language | eng |
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| source | Access via Wiley Online Library; MEDLINE |
| subjects | Adult Antifungal Agents - therapeutic use Aspergillosis - drug therapy Aspergillosis - microbiology Aspergillus caspofungin combination treatment Cytomegalovirus Echinocandins Female Humans invasive aspergillosis leishmaniasis Lipopeptides liver transplantation Liver Transplantation - adverse effects Peptides - therapeutic use Peptides, Cyclic Pyrimidines - therapeutic use Sinusitis - drug therapy Sinusitis - microbiology Treatment Outcome Triazoles - therapeutic use Voriconazole |
| title | Deep sinus aspergillosis in a liver transplant recipient successfully treated with a combination of caspofungin and voriconazole |
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