Cellular mechanisms governing cross-presentation of exogenous antigens
The recent discovery of fusion of endoplasmic reticulum membrane with nascent phagosomes suggests that this peripheral compartment in macrophages and dendritic cells may serve as an organelle optimized for major histocompatibility complex (MHC) class I–restricted cross-presentation of exogenous anti...
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| Veröffentlicht in: | Nature immunology 2004-07, Vol.5 (7), p.678-684 |
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| container_title | Nature immunology |
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| creator | Cresswell, Peter Ackerman, Anne L |
| description | The recent discovery of fusion of endoplasmic reticulum membrane with nascent phagosomes suggests that this peripheral compartment in macrophages and dendritic cells may serve as an organelle optimized for major histocompatibility complex (MHC) class I–restricted cross-presentation of exogenous antigens. The process allows intersection of the endosomal system with the endoplasmic reticulum, the classical site of MHC class I peptide loading, and may reconcile the seemingly conflicting evidence indicating both of these sites are crucial in cross-presentation. Here we discuss the potential mechanisms involved in loading exogenous antigens onto MHC class I molecules and the implications of this new evidence for the
in vivo
function of dendritic cells. |
| doi_str_mv | 10.1038/ni1082 |
| format | Article |
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in vivo
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in vivo
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in vivo
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| subjects | Animals Antigen presentation Antigen Presentation - immunology Antigens Antigens - immunology Biomedical and Life Sciences Biomedicine Cross-Priming - immunology Dendritic cells Endocytosis Endoplasmic reticulum Endoplasmic Reticulum - metabolism Humans Immunology Infectious Diseases Macrophages Major histocompatibility complex Membrane fusion Phagocytosis Phagosomes review-article |
| title | Cellular mechanisms governing cross-presentation of exogenous antigens |
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