Effects of acute leg ischemia during cycling on oxygen and carbon dioxide stores
This study estimated changes in whole body oxygen stores (O(2)s) and carbon dioxide stores (CO(2)s) during steady state exercise with leg ischemia induced by leg cuff inflation. Six physically fit subjects performed 75 W steady state exercise for 15 min on a cycle ergometer. After 5 min of exercise,...
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| Veröffentlicht in: | Journal of rehabilitation research and development 2008-01, Vol.45 (7), p.1091-1102 |
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| creator | Loeppky, Jack A Gurney, Burke Icenogle, Milton V |
| description | This study estimated changes in whole body oxygen stores (O(2)s) and carbon dioxide stores (CO(2)s) during steady state exercise with leg ischemia induced by leg cuff inflation. Six physically fit subjects performed 75 W steady state exercise for 15 min on a cycle ergometer. After 5 min of exercise, cuffs on the upper and lower legs were inflated to 140 mmHg. Cuffs were deflated after 5 min and exercise continued for another 5 min. O(2 )uptake (VO(2)) and CO(2) output (VCO(2)) significantly increased during the first 30 s after inflation, significantly decreased between 60 and 90 s, and then rose linearly until deflation. VO(2) and VCO(2) significantly increased further after cuff deflation, peaking between 30 and 60 s and then returned to near baseline exercise levels. Model-estimated changes in total O(2)s and CO(2)s were compared with time-integrated store changes from VO(2) and VCO(2). During 5 min after cuff deflation, VO(2) and VCO(2) exceeded the model-estimated change in stores by 273 and 697 mL, respectively. These results reflect the O(2) cost repayment of the anaerobic component and lactate buffering to neutralize circulating metabolites caused by the preceding ischemia. |
| doi_str_mv | 10.1682/JRRD.2007.11.0198 |
| format | Article |
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Six physically fit subjects performed 75 W steady state exercise for 15 min on a cycle ergometer. After 5 min of exercise, cuffs on the upper and lower legs were inflated to 140 mmHg. Cuffs were deflated after 5 min and exercise continued for another 5 min. O(2 )uptake (VO(2)) and CO(2) output (VCO(2)) significantly increased during the first 30 s after inflation, significantly decreased between 60 and 90 s, and then rose linearly until deflation. VO(2) and VCO(2) significantly increased further after cuff deflation, peaking between 30 and 60 s and then returned to near baseline exercise levels. Model-estimated changes in total O(2)s and CO(2)s were compared with time-integrated store changes from VO(2) and VCO(2). During 5 min after cuff deflation, VO(2) and VCO(2) exceeded the model-estimated change in stores by 273 and 697 mL, respectively. These results reflect the O(2) cost repayment of the anaerobic component and lactate buffering to neutralize circulating metabolites caused by the preceding ischemia.</description><identifier>ISSN: 0748-7711</identifier><identifier>EISSN: 1938-1352</identifier><identifier>DOI: 10.1682/JRRD.2007.11.0198</identifier><identifier>PMID: 19165697</identifier><identifier>CODEN: JRRDDB</identifier><language>eng</language><publisher>United States: Department of Veterans Affairs</publisher><subject>Adult ; Carbon dioxide ; Carbon Dioxide - metabolism ; Changes ; Chronic illnesses ; Chronic obstructive pulmonary disease ; Exercise ; Exercise - physiology ; Exercise Test ; Exercise Therapy - methods ; Feasibility Studies ; Female ; Gases ; Health aspects ; Humans ; Inflation ; Injuries ; Ischemia ; Ischemia - physiopathology ; Leg ; Leg - blood supply ; Leg - physiology ; Male ; Middle Aged ; Oxygen Consumption ; Physical Endurance ; Physical fitness ; Physiological aspects ; Resistance Training ; Risk factors ; Ventilation ; Veterans ; Young Adult</subject><ispartof>Journal of rehabilitation research and development, 2008-01, Vol.45 (7), p.1091-1102</ispartof><rights>COPYRIGHT 2008 Department of Veterans Affairs</rights><rights>Copyright Superintendent of Documents 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-2fbf81d7c44cec59baeb25d92ab2148c8fc041adafc821c9f33c68dbbf4b86203</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19165697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Loeppky, Jack A</creatorcontrib><creatorcontrib>Gurney, Burke</creatorcontrib><creatorcontrib>Icenogle, Milton V</creatorcontrib><title>Effects of acute leg ischemia during cycling on oxygen and carbon dioxide stores</title><title>Journal of rehabilitation research and development</title><addtitle>J Rehabil Res Dev</addtitle><description>This study estimated changes in whole body oxygen stores (O(2)s) and carbon dioxide stores (CO(2)s) during steady state exercise with leg ischemia induced by leg cuff inflation. Six physically fit subjects performed 75 W steady state exercise for 15 min on a cycle ergometer. After 5 min of exercise, cuffs on the upper and lower legs were inflated to 140 mmHg. Cuffs were deflated after 5 min and exercise continued for another 5 min. O(2 )uptake (VO(2)) and CO(2) output (VCO(2)) significantly increased during the first 30 s after inflation, significantly decreased between 60 and 90 s, and then rose linearly until deflation. VO(2) and VCO(2) significantly increased further after cuff deflation, peaking between 30 and 60 s and then returned to near baseline exercise levels. Model-estimated changes in total O(2)s and CO(2)s were compared with time-integrated store changes from VO(2) and VCO(2). During 5 min after cuff deflation, VO(2) and VCO(2) exceeded the model-estimated change in stores by 273 and 697 mL, respectively. These results reflect the O(2) cost repayment of the anaerobic component and lactate buffering to neutralize circulating metabolites caused by the preceding ischemia.</description><subject>Adult</subject><subject>Carbon dioxide</subject><subject>Carbon Dioxide - metabolism</subject><subject>Changes</subject><subject>Chronic illnesses</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Exercise Therapy - methods</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Gases</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Inflation</subject><subject>Injuries</subject><subject>Ischemia</subject><subject>Ischemia - physiopathology</subject><subject>Leg</subject><subject>Leg - blood supply</subject><subject>Leg - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen Consumption</subject><subject>Physical Endurance</subject><subject>Physical fitness</subject><subject>Physiological aspects</subject><subject>Resistance Training</subject><subject>Risk factors</subject><subject>Ventilation</subject><subject>Veterans</subject><subject>Young Adult</subject><issn>0748-7711</issn><issn>1938-1352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6A7xI8OCt21Q6nU6Oy7p-saAseg5JJRl76emsSTfs_HvTzIDgxeRQUDxvqMpDyGtgLUjF33-9u_vQcsaGFqBloNUTsgPdqQa6nj8lOzYI1QwDwAV5Uco9Y4x3HJ6TC9Age6mHHfl-E2PApdAUqcV1CXQKezoW_BUOo6V-zeO8p3jEaatppunxuA8ztbOnaLOrHT-mx9EHWpaUQ3lJnkU7lfDqXC_Jz483P64_N7ffPn25vrptUHR6aXh0UYEfUAgM2Gtng-O919w6DkKhisgEWG8jKg6oY9ehVN65KJySnHWX5N3p3Yecfq-hLOZQpw7TZOeQ1mJkPYJJ_V8QtBRCAq_g23_A-7TmuS5hOPRcSYC-Qu0J2tspmHGOackW6_X1vzDNIY61f8VZz7TgXNQAnAKYUyk5RPOQx4PNRwPMbBbNZtFsFg2A2SzWzJvzJKs7BP83cdbW_QGA5JfH</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Loeppky, Jack A</creator><creator>Gurney, Burke</creator><creator>Icenogle, Milton V</creator><general>Department of Veterans Affairs</general><general>Superintendent of Documents</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QO</scope><scope>7RV</scope><scope>7TK</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Effects of acute leg ischemia during cycling on oxygen and carbon dioxide stores</title><author>Loeppky, Jack A ; Gurney, Burke ; Icenogle, Milton V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-2fbf81d7c44cec59baeb25d92ab2148c8fc041adafc821c9f33c68dbbf4b86203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Carbon dioxide</topic><topic>Carbon Dioxide - metabolism</topic><topic>Changes</topic><topic>Chronic illnesses</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Exercise Therapy - methods</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Gases</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Inflation</topic><topic>Injuries</topic><topic>Ischemia</topic><topic>Ischemia - physiopathology</topic><topic>Leg</topic><topic>Leg - blood supply</topic><topic>Leg - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxygen Consumption</topic><topic>Physical Endurance</topic><topic>Physical fitness</topic><topic>Physiological aspects</topic><topic>Resistance Training</topic><topic>Risk factors</topic><topic>Ventilation</topic><topic>Veterans</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Loeppky, Jack A</creatorcontrib><creatorcontrib>Gurney, Burke</creatorcontrib><creatorcontrib>Icenogle, Milton V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of rehabilitation research and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loeppky, Jack A</au><au>Gurney, Burke</au><au>Icenogle, Milton V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of acute leg ischemia during cycling on oxygen and carbon dioxide stores</atitle><jtitle>Journal of rehabilitation research and development</jtitle><addtitle>J Rehabil Res Dev</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>45</volume><issue>7</issue><spage>1091</spage><epage>1102</epage><pages>1091-1102</pages><issn>0748-7711</issn><eissn>1938-1352</eissn><coden>JRRDDB</coden><abstract>This study estimated changes in whole body oxygen stores (O(2)s) and carbon dioxide stores (CO(2)s) during steady state exercise with leg ischemia induced by leg cuff inflation. Six physically fit subjects performed 75 W steady state exercise for 15 min on a cycle ergometer. After 5 min of exercise, cuffs on the upper and lower legs were inflated to 140 mmHg. Cuffs were deflated after 5 min and exercise continued for another 5 min. O(2 )uptake (VO(2)) and CO(2) output (VCO(2)) significantly increased during the first 30 s after inflation, significantly decreased between 60 and 90 s, and then rose linearly until deflation. VO(2) and VCO(2) significantly increased further after cuff deflation, peaking between 30 and 60 s and then returned to near baseline exercise levels. Model-estimated changes in total O(2)s and CO(2)s were compared with time-integrated store changes from VO(2) and VCO(2). During 5 min after cuff deflation, VO(2) and VCO(2) exceeded the model-estimated change in stores by 273 and 697 mL, respectively. These results reflect the O(2) cost repayment of the anaerobic component and lactate buffering to neutralize circulating metabolites caused by the preceding ischemia.</abstract><cop>United States</cop><pub>Department of Veterans Affairs</pub><pmid>19165697</pmid><doi>10.1682/JRRD.2007.11.0198</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; U.S. Government Documents; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Carbon dioxide Carbon Dioxide - metabolism Changes Chronic illnesses Chronic obstructive pulmonary disease Exercise Exercise - physiology Exercise Test Exercise Therapy - methods Feasibility Studies Female Gases Health aspects Humans Inflation Injuries Ischemia Ischemia - physiopathology Leg Leg - blood supply Leg - physiology Male Middle Aged Oxygen Consumption Physical Endurance Physical fitness Physiological aspects Resistance Training Risk factors Ventilation Veterans Young Adult |
| title | Effects of acute leg ischemia during cycling on oxygen and carbon dioxide stores |
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