Echocardiographic abnormalities in sickle cell disease
Echocardiographic abnormalities in patients with sickle cell disease (SCD) were determined, and pulmonary arterial systolic pressure (PASP) was estimated. Clinical data and echocardiograms of 38 adult hospitalized patients with SCD at two tertiary care hospitals were reviewed. Fisher's exact te...
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| Veröffentlicht in: | American journal of hematology 2004-07, Vol.76 (3), p.195-198 |
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| container_title | American journal of hematology |
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| creator | Ahmed, Shahid Siddiqui, Anita K. Sadiq, Adnan Shahid, Rabia K. Patel, Dilip V Russo, Linda A. |
| description | Echocardiographic abnormalities in patients with sickle cell disease (SCD) were determined, and pulmonary arterial systolic pressure (PASP) was estimated. Clinical data and echocardiograms of 38 adult hospitalized patients with SCD at two tertiary care hospitals were reviewed. Fisher's exact test was performed to determine correlation between pulmonary hypertension and various clinical variables. Pulmonary hypertension was the most common abnormality identified in 22 (58%) patients. The estimated mean PASP was 37.5 ± 10.9 mmHg. Older age and prior history of acute chest syndrome were significantly correlated with an increased prevalence of pulmonary hypertension (P < 0.05). Patients with hemoglobin levels |
| doi_str_mv | 10.1002/ajh.20118 |
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Clinical data and echocardiograms of 38 adult hospitalized patients with SCD at two tertiary care hospitals were reviewed. Fisher's exact test was performed to determine correlation between pulmonary hypertension and various clinical variables. Pulmonary hypertension was the most common abnormality identified in 22 (58%) patients. The estimated mean PASP was 37.5 ± 10.9 mmHg. Older age and prior history of acute chest syndrome were significantly correlated with an increased prevalence of pulmonary hypertension (P < 0.05). Patients with hemoglobin levels <8 g/dL had PASP 43.2 ± 0.5 compared to a mean PASP of 33.3 ± 6.0 in patients with hemoglobin ≥8 g/dL (P = 0.01). Eight (21%) patients had evidence of a hyperdynamic left ventricle. Left heart abnormalities included dilated atrium in 14 (37%), dilated ventricle in 5 (13%), ventricle hypertrophy in 5 (13%), and ventricle dysfunction in 3 (9%) patients. Right heart abnormalities included dilated atrium in 9 (24%), dilated ventricle in 6 (16%), and ventricle dysfunction in 3 (9%) patients. Despite an increased incidence of abnormal flow across the valves on Doppler analysis, no patient had structurally abnormal valves. A majority of patients with SCD had evidence of pulmonary hypertension, which correlated with older age and history of acute chest syndrome. Other structural and functional echocardiographic abnormalities were less common. Am. J. Hematol. 76:195–198, 2004. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.20118</identifier><identifier>PMID: 15224351</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>acute chest syndrome ; Adult ; anemia ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - diagnostic imaging ; Anemia, Sickle Cell - physiopathology ; Anemias. Hemoglobinopathies ; Biological and medical sciences ; cardiac dysfunction ; Cardiovascular Diseases - diagnostic imaging ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Diseases of red blood cells ; echocardiogram ; Echocardiography ; Female ; Heart Atria - diagnostic imaging ; Hematologic and hematopoietic diseases ; Hemoglobins - analysis ; Humans ; Hypertension, Pulmonary - diagnostic imaging ; Hypertension, Pulmonary - epidemiology ; Hypertrophy, Left Ventricular - diagnostic imaging ; Hypertrophy, Left Ventricular - epidemiology ; Male ; Medical sciences ; Middle Aged ; Mitral Valve Insufficiency - diagnostic imaging ; Mitral Valve Insufficiency - epidemiology ; Pneumology ; pulmonary hypertension ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; sickle cell disease ; Tricuspid Valve Insufficiency - diagnostic imaging ; Tricuspid Valve Insufficiency - epidemiology ; valve regurgitation ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - epidemiology ; Ventricular Dysfunction, Right - diagnostic imaging ; Ventricular Dysfunction, Right - epidemiology</subject><ispartof>American journal of hematology, 2004-07, Vol.76 (3), p.195-198</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc., A Wiley Company</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3518-1be69a5922472b750d583df706992db667438ee9e1357b312fea4537c5f4a3533</citedby><cites>FETCH-LOGICAL-c3518-1be69a5922472b750d583df706992db667438ee9e1357b312fea4537c5f4a3533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajh.20118$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajh.20118$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15904139$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15224351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Shahid</creatorcontrib><creatorcontrib>Siddiqui, Anita K.</creatorcontrib><creatorcontrib>Sadiq, Adnan</creatorcontrib><creatorcontrib>Shahid, Rabia K.</creatorcontrib><creatorcontrib>Patel, Dilip V</creatorcontrib><creatorcontrib>Russo, Linda A.</creatorcontrib><title>Echocardiographic abnormalities in sickle cell disease</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>Echocardiographic abnormalities in patients with sickle cell disease (SCD) were determined, and pulmonary arterial systolic pressure (PASP) was estimated. Clinical data and echocardiograms of 38 adult hospitalized patients with SCD at two tertiary care hospitals were reviewed. Fisher's exact test was performed to determine correlation between pulmonary hypertension and various clinical variables. Pulmonary hypertension was the most common abnormality identified in 22 (58%) patients. The estimated mean PASP was 37.5 ± 10.9 mmHg. Older age and prior history of acute chest syndrome were significantly correlated with an increased prevalence of pulmonary hypertension (P < 0.05). Patients with hemoglobin levels <8 g/dL had PASP 43.2 ± 0.5 compared to a mean PASP of 33.3 ± 6.0 in patients with hemoglobin ≥8 g/dL (P = 0.01). Eight (21%) patients had evidence of a hyperdynamic left ventricle. Left heart abnormalities included dilated atrium in 14 (37%), dilated ventricle in 5 (13%), ventricle hypertrophy in 5 (13%), and ventricle dysfunction in 3 (9%) patients. Right heart abnormalities included dilated atrium in 9 (24%), dilated ventricle in 6 (16%), and ventricle dysfunction in 3 (9%) patients. Despite an increased incidence of abnormal flow across the valves on Doppler analysis, no patient had structurally abnormal valves. A majority of patients with SCD had evidence of pulmonary hypertension, which correlated with older age and history of acute chest syndrome. Other structural and functional echocardiographic abnormalities were less common. Am. J. Hematol. 76:195–198, 2004. © 2004 Wiley‐Liss, Inc.</description><subject>acute chest syndrome</subject><subject>Adult</subject><subject>anemia</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - diagnostic imaging</subject><subject>Anemia, Sickle Cell - physiopathology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>cardiac dysfunction</subject><subject>Cardiovascular Diseases - diagnostic imaging</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Diseases of red blood cells</subject><subject>echocardiogram</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart Atria - diagnostic imaging</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - diagnostic imaging</subject><subject>Hypertension, Pulmonary - epidemiology</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>Hypertrophy, Left Ventricular - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitral Valve Insufficiency - diagnostic imaging</subject><subject>Mitral Valve Insufficiency - epidemiology</subject><subject>Pneumology</subject><subject>pulmonary hypertension</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>sickle cell disease</subject><subject>Tricuspid Valve Insufficiency - diagnostic imaging</subject><subject>Tricuspid Valve Insufficiency - epidemiology</subject><subject>valve regurgitation</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - epidemiology</subject><subject>Ventricular Dysfunction, Right - diagnostic imaging</subject><subject>Ventricular Dysfunction, Right - epidemiology</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10LtOwzAYBWALgWgpDLwAygISQ1pfYiceq6pQUCUWmC3H-UNdcil2I9S3xyWRYMGLPXw6xzoIXRM8JRjTmd5uphQTkp2gMcFSxJng9BSNMRMkvLEcoQvvtziQJMPnaEQ4pQnjZIzE0mxao11h23endxtrIp03rat1ZfcWfGSbyFvzUUFkoKqiwnrQHi7RWakrD1fDPUFvD8vXxSpevzw-Lebr2IT0LCY5CKm5DG0pzVOOC56xokyxkJIWuRBpwjIACYTxNGeElqATzlLDy0QzztgE3fW5O9d-duD3qrb--BHdQNt5JcJhaYIDvO-hca33Dkq1c7bW7qAIVseRVBhJ_YwU7M0Q2uU1FL9yWCWA2wFob3RVOt0Y6_84iRPCZHCz3n3ZCg7_N6r586qv_gZalHuF</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Ahmed, Shahid</creator><creator>Siddiqui, Anita K.</creator><creator>Sadiq, Adnan</creator><creator>Shahid, Rabia K.</creator><creator>Patel, Dilip V</creator><creator>Russo, Linda A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200407</creationdate><title>Echocardiographic abnormalities in sickle cell disease</title><author>Ahmed, Shahid ; Siddiqui, Anita K. ; Sadiq, Adnan ; Shahid, Rabia K. ; Patel, Dilip V ; Russo, Linda A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3518-1be69a5922472b750d583df706992db667438ee9e1357b312fea4537c5f4a3533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>acute chest syndrome</topic><topic>Adult</topic><topic>anemia</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - diagnostic imaging</topic><topic>Anemia, Sickle Cell - physiopathology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>cardiac dysfunction</topic><topic>Cardiovascular Diseases - diagnostic imaging</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Diseases of red blood cells</topic><topic>echocardiogram</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart Atria - diagnostic imaging</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - diagnostic imaging</topic><topic>Hypertension, Pulmonary - epidemiology</topic><topic>Hypertrophy, Left Ventricular - diagnostic imaging</topic><topic>Hypertrophy, Left Ventricular - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitral Valve Insufficiency - diagnostic imaging</topic><topic>Mitral Valve Insufficiency - epidemiology</topic><topic>Pneumology</topic><topic>pulmonary hypertension</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>sickle cell disease</topic><topic>Tricuspid Valve Insufficiency - diagnostic imaging</topic><topic>Tricuspid Valve Insufficiency - epidemiology</topic><topic>valve regurgitation</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - epidemiology</topic><topic>Ventricular Dysfunction, Right - diagnostic imaging</topic><topic>Ventricular Dysfunction, Right - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Shahid</creatorcontrib><creatorcontrib>Siddiqui, Anita K.</creatorcontrib><creatorcontrib>Sadiq, Adnan</creatorcontrib><creatorcontrib>Shahid, Rabia K.</creatorcontrib><creatorcontrib>Patel, Dilip V</creatorcontrib><creatorcontrib>Russo, Linda A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Shahid</au><au>Siddiqui, Anita K.</au><au>Sadiq, Adnan</au><au>Shahid, Rabia K.</au><au>Patel, Dilip V</au><au>Russo, Linda A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Echocardiographic abnormalities in sickle cell disease</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>2004-07</date><risdate>2004</risdate><volume>76</volume><issue>3</issue><spage>195</spage><epage>198</epage><pages>195-198</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>Echocardiographic abnormalities in patients with sickle cell disease (SCD) were determined, and pulmonary arterial systolic pressure (PASP) was estimated. Clinical data and echocardiograms of 38 adult hospitalized patients with SCD at two tertiary care hospitals were reviewed. Fisher's exact test was performed to determine correlation between pulmonary hypertension and various clinical variables. Pulmonary hypertension was the most common abnormality identified in 22 (58%) patients. The estimated mean PASP was 37.5 ± 10.9 mmHg. Older age and prior history of acute chest syndrome were significantly correlated with an increased prevalence of pulmonary hypertension (P < 0.05). Patients with hemoglobin levels <8 g/dL had PASP 43.2 ± 0.5 compared to a mean PASP of 33.3 ± 6.0 in patients with hemoglobin ≥8 g/dL (P = 0.01). Eight (21%) patients had evidence of a hyperdynamic left ventricle. Left heart abnormalities included dilated atrium in 14 (37%), dilated ventricle in 5 (13%), ventricle hypertrophy in 5 (13%), and ventricle dysfunction in 3 (9%) patients. Right heart abnormalities included dilated atrium in 9 (24%), dilated ventricle in 6 (16%), and ventricle dysfunction in 3 (9%) patients. Despite an increased incidence of abnormal flow across the valves on Doppler analysis, no patient had structurally abnormal valves. A majority of patients with SCD had evidence of pulmonary hypertension, which correlated with older age and history of acute chest syndrome. Other structural and functional echocardiographic abnormalities were less common. Am. J. Hematol. 76:195–198, 2004. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15224351</pmid><doi>10.1002/ajh.20118</doi><tpages>4</tpages></addata></record> |
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| subjects | acute chest syndrome Adult anemia Anemia, Sickle Cell - complications Anemia, Sickle Cell - diagnostic imaging Anemia, Sickle Cell - physiopathology Anemias. Hemoglobinopathies Biological and medical sciences cardiac dysfunction Cardiovascular Diseases - diagnostic imaging Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Diseases of red blood cells echocardiogram Echocardiography Female Heart Atria - diagnostic imaging Hematologic and hematopoietic diseases Hemoglobins - analysis Humans Hypertension, Pulmonary - diagnostic imaging Hypertension, Pulmonary - epidemiology Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - epidemiology Male Medical sciences Middle Aged Mitral Valve Insufficiency - diagnostic imaging Mitral Valve Insufficiency - epidemiology Pneumology pulmonary hypertension Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases sickle cell disease Tricuspid Valve Insufficiency - diagnostic imaging Tricuspid Valve Insufficiency - epidemiology valve regurgitation Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - epidemiology Ventricular Dysfunction, Right - diagnostic imaging Ventricular Dysfunction, Right - epidemiology |
| title | Echocardiographic abnormalities in sickle cell disease |
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