4-Acylamino-6-arylfuro[2,3- d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors

A novel and potent series of selective GSK-3 inhibitors are described. Some derivatives showed excellent potency in a cellular assay. Modeling studies of a furo[2,3- d]pyrimidine GSK-3 hit compound 1 superimposed onto the X-ray crystal structure of a legacy pyrazolo[3,4- c]pyridazine GSK-3 inhibitor...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-08, Vol.14 (15), p.3907-3911
Hauptverfasser:	Maeda, Yutaka, Nakano, Masato, Sato, Hideyuki, Miyazaki, Yasushi, Schweiker, Stephanie L, Smith, Jeffery L, Truesdale, Anne T
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - chemistry Glycogen synthase kinase-3 inhibitors Kinetics Medical sciences Miscellaneous Models, Molecular Pharmacology. Drug treatments Pyrimidines - chemical synthesis Pyrimidines - pharmacology Structure-Activity Relationship Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors
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