Fluoxetine and sertraline stimulate gastric acid secretion via a vagal pathway in anaesthetised rats
The effect of the selective serotonin reuptake inhibitors, fluoxetine and sertraline on basal, secretagogues (histamine or bethanechol)- and distention-stimulated gastric acid secretion was investigated in the urethane-anaesthetised acute gastric fistula rat. Gastric acid secretion was measured by f...
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| description | The effect of the selective serotonin reuptake inhibitors, fluoxetine and sertraline on basal, secretagogues (histamine or bethanechol)- and distention-stimulated gastric acid secretion was investigated in the urethane-anaesthetised acute gastric fistula rat. Gastric acid secretion was measured by flushing of the gastric contents with saline every 15
min. Fluoxetine (10 or 20
mg
kg
−1, i.p.) produced a dose-dependent increase in basal gastric acid secretion. These stimulatory effects were abolished by vagotomy. Intraperitoneally administered sertraline also stimulated gastric acid secretion. The stimulatory effect of lower doses (5
mg
kg
−1) of sertraline was similar to that of the higher (30
mg
kg
−1) doses. The gastric secretory response to i.p. sertraline was long lasting (greater than 60
min), and blocked by vagotomy. Intraperitoneally administered fluoxetine (10 or 20
mg
kg
−1) or sertraline (5
mg
kg
−1) also increased gastric secretion induced by histamine, bethanechol or distention. The fluoxetine or sertraline stimulatory effects of histamine-induced acid secretion were abolished by vagotomy. Data indicate a stimulatory effect for fluoxetine and sertraline mediated by vagal nerve on gastric acid secretion in urethane-anaesthetised rats. |
| doi_str_mv | 10.1016/j.phrs.2004.01.010 |
| format | Article |
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min. Fluoxetine (10 or 20
mg
kg
−1, i.p.) produced a dose-dependent increase in basal gastric acid secretion. These stimulatory effects were abolished by vagotomy. Intraperitoneally administered sertraline also stimulated gastric acid secretion. The stimulatory effect of lower doses (5
mg
kg
−1) of sertraline was similar to that of the higher (30
mg
kg
−1) doses. The gastric secretory response to i.p. sertraline was long lasting (greater than 60
min), and blocked by vagotomy. Intraperitoneally administered fluoxetine (10 or 20
mg
kg
−1) or sertraline (5
mg
kg
−1) also increased gastric secretion induced by histamine, bethanechol or distention. The fluoxetine or sertraline stimulatory effects of histamine-induced acid secretion were abolished by vagotomy. Data indicate a stimulatory effect for fluoxetine and sertraline mediated by vagal nerve on gastric acid secretion in urethane-anaesthetised rats.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/j.phrs.2004.01.010</identifier><identifier>PMID: 15225675</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Anesthesia ; Animals ; Dose-Response Relationship, Drug ; Female ; Fluoxetine ; Fluoxetine - pharmacology ; Gastric acid ; Gastric Acid - secretion ; Male ; Neural Pathways - drug effects ; Rats ; Rats, Sprague-Dawley ; Sertraline ; Sertraline - pharmacology ; Urethane-anaesthetized rat ; Vagus Nerve - drug effects ; Vagus Nerve - secretion</subject><ispartof>Pharmacological research, 2004-09, Vol.50 (3), p.309-316</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-f80e6265a82f126e399d8f1ac437f8ce20ff84f6c3e8ee6d4ecaf46c0c849ff03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phrs.2004.01.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15225675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdel Salam, Omar M.E</creatorcontrib><title>Fluoxetine and sertraline stimulate gastric acid secretion via a vagal pathway in anaesthetised rats</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>The effect of the selective serotonin reuptake inhibitors, fluoxetine and sertraline on basal, secretagogues (histamine or bethanechol)- and distention-stimulated gastric acid secretion was investigated in the urethane-anaesthetised acute gastric fistula rat. Gastric acid secretion was measured by flushing of the gastric contents with saline every 15
min. Fluoxetine (10 or 20
mg
kg
−1, i.p.) produced a dose-dependent increase in basal gastric acid secretion. These stimulatory effects were abolished by vagotomy. Intraperitoneally administered sertraline also stimulated gastric acid secretion. The stimulatory effect of lower doses (5
mg
kg
−1) of sertraline was similar to that of the higher (30
mg
kg
−1) doses. The gastric secretory response to i.p. sertraline was long lasting (greater than 60
min), and blocked by vagotomy. Intraperitoneally administered fluoxetine (10 or 20
mg
kg
−1) or sertraline (5
mg
kg
−1) also increased gastric secretion induced by histamine, bethanechol or distention. The fluoxetine or sertraline stimulatory effects of histamine-induced acid secretion were abolished by vagotomy. Data indicate a stimulatory effect for fluoxetine and sertraline mediated by vagal nerve on gastric acid secretion in urethane-anaesthetised rats.</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fluoxetine</subject><subject>Fluoxetine - pharmacology</subject><subject>Gastric acid</subject><subject>Gastric Acid - secretion</subject><subject>Male</subject><subject>Neural Pathways - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sertraline</subject><subject>Sertraline - pharmacology</subject><subject>Urethane-anaesthetized rat</subject><subject>Vagus Nerve - drug effects</subject><subject>Vagus Nerve - secretion</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMofv8BD5KTt66TtI0peBHxCwQveg5jOnGzdNs1SVf996bsgjfDQDLwzMPkZexMwEyAUJeL2Woe4kwCVDMQuWCHHQpoVCGEVrvTuyoLpYQ-YEcxLgCgqQTsswNRS1mrq_qQtffdOHxT8j1x7FseKaSA3dTG5Jdjh4n4B8YUvOVo_UTYkPmh52uPHPkaP7DjK0zzL_zhvs8apJjmmYnU8oApnrA9h12k0-19zN7u715vH4vnl4en25vnwpa1TIXTQEqqGrV0Qioqm6bVTqCtyiunLUlwTldO2ZI0kWorsugqZcHqqnEOymN2sfGuwvA55iXM0kdLXYc9DWM0Kh8ptMyg3IA2DDEGcmYV_BLDjxFgpmzNwkzZmilbAyLXZD_f2sf3JbV_I9swM3C9ASj_ce0pmGg99ZZaH8gm0w7-P_8vhDKNOw</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Abdel Salam, Omar M.E</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Fluoxetine and sertraline stimulate gastric acid secretion via a vagal pathway in anaesthetised rats</title><author>Abdel Salam, Omar M.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-f80e6265a82f126e399d8f1ac437f8ce20ff84f6c3e8ee6d4ecaf46c0c849ff03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fluoxetine</topic><topic>Fluoxetine - pharmacology</topic><topic>Gastric acid</topic><topic>Gastric Acid - secretion</topic><topic>Male</topic><topic>Neural Pathways - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sertraline</topic><topic>Sertraline - pharmacology</topic><topic>Urethane-anaesthetized rat</topic><topic>Vagus Nerve - drug effects</topic><topic>Vagus Nerve - secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdel Salam, Omar M.E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdel Salam, Omar M.E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluoxetine and sertraline stimulate gastric acid secretion via a vagal pathway in anaesthetised rats</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>50</volume><issue>3</issue><spage>309</spage><epage>316</epage><pages>309-316</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>The effect of the selective serotonin reuptake inhibitors, fluoxetine and sertraline on basal, secretagogues (histamine or bethanechol)- and distention-stimulated gastric acid secretion was investigated in the urethane-anaesthetised acute gastric fistula rat. Gastric acid secretion was measured by flushing of the gastric contents with saline every 15
min. Fluoxetine (10 or 20
mg
kg
−1, i.p.) produced a dose-dependent increase in basal gastric acid secretion. These stimulatory effects were abolished by vagotomy. Intraperitoneally administered sertraline also stimulated gastric acid secretion. The stimulatory effect of lower doses (5
mg
kg
−1) of sertraline was similar to that of the higher (30
mg
kg
−1) doses. The gastric secretory response to i.p. sertraline was long lasting (greater than 60
min), and blocked by vagotomy. Intraperitoneally administered fluoxetine (10 or 20
mg
kg
−1) or sertraline (5
mg
kg
−1) also increased gastric secretion induced by histamine, bethanechol or distention. The fluoxetine or sertraline stimulatory effects of histamine-induced acid secretion were abolished by vagotomy. Data indicate a stimulatory effect for fluoxetine and sertraline mediated by vagal nerve on gastric acid secretion in urethane-anaesthetised rats.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>15225675</pmid><doi>10.1016/j.phrs.2004.01.010</doi><tpages>8</tpages></addata></record> |
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| ispartof | Pharmacological research, 2004-09, Vol.50 (3), p.309-316 |
| issn | 1043-6618 1096-1186 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Anesthesia Animals Dose-Response Relationship, Drug Female Fluoxetine Fluoxetine - pharmacology Gastric acid Gastric Acid - secretion Male Neural Pathways - drug effects Rats Rats, Sprague-Dawley Sertraline Sertraline - pharmacology Urethane-anaesthetized rat Vagus Nerve - drug effects Vagus Nerve - secretion |
| title | Fluoxetine and sertraline stimulate gastric acid secretion via a vagal pathway in anaesthetised rats |
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