Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter

We investigated the signaling pathways participating in hyperosmotic regulation of the human taurine transporter (TAUT) by using specific inhibitors of various intracellular signaling molecules. Among them, the specific inhibitor of calcium/calmodulin-dependent protein kinase II (Ca2+/CaM kinase II)...

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Veröffentlicht in:	FEBS letters 2004-07, Vol.569 (1-3), p.123-128
Hauptverfasser:	Satsu, Hideo, Manabe, Mariko, Shimizu, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	AR, aldose reductase Benzylamines - pharmacology BGT1, betaine/γ-amino-n-butyric acid transporter 1 Ca2+/CaM kinase II, calcium/calmodulin-dependent protein kinase II Caco-2 Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - metabolism Calcium/calmodulin-dependent protein kinase II (Ca2+/CaM kinase II) Carrier Proteins - biosynthesis Carrier Proteins - genetics Cell Line, Tumor Colonic Neoplasms CREB, cAMP-responsive element-binding protein DIDS, 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid DMEM, Dulbecco's modified Eagle's medium Enzyme Activation Enzyme Inhibitors - pharmacology ERK, extracellular signal-regulated kinase Et-18-OCH3, 1-O octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine FCS, fetal calf serum Flavonoids - pharmacology Gene Expression Regulation, Neoplastic - genetics HBSS, Hank's balanced salt solution Humans Imidazoles - pharmacology JNK, Jun N-terminal kinase Kinetics LPC, lysophosphatidylcholine MAP kinase, mitogen-activated protein kinase Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Transport Proteins Osmolar Concentration Osmoregulation PBS, phosphate-buffered saline PDTC, pyrrolidine dithiocarbamate PKA, protein kinase A PKC, protein kinase C Pyridines - pharmacology RNA, Messenger - genetics SMIT, myo-inositol transporter Sulfonamides - pharmacology Taurine TAUT, taurine transporter Transporter
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