Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter
We investigated the signaling pathways participating in hyperosmotic regulation of the human taurine transporter (TAUT) by using specific inhibitors of various intracellular signaling molecules. Among them, the specific inhibitor of calcium/calmodulin-dependent protein kinase II (Ca2+/CaM kinase II)...
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| Veröffentlicht in: | FEBS letters 2004-07, Vol.569 (1-3), p.123-128 |
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| creator | Satsu, Hideo Manabe, Mariko Shimizu, Makoto |
| description | We investigated the signaling pathways participating in hyperosmotic regulation of the human taurine transporter (TAUT) by using specific inhibitors of various intracellular signaling molecules. Among them, the specific inhibitor of calcium/calmodulin-dependent protein kinase II (Ca2+/CaM kinase II) completely repressed the hyperosmotic regulation of TAUT. The osmosensitive upregulation of TAUT was also significantly inhibited by calmodulin antagonists and calcium-chelators. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca2+/CaM kinase II inhibitor. The activated form of Ca2+/CaM kinase II protein could only be detected in Caco-2 cells under hypertonic conditions. |
| doi_str_mv | 10.1016/j.febslet.2004.05.062 |
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Among them, the specific inhibitor of calcium/calmodulin-dependent protein kinase II (Ca2+/CaM kinase II) completely repressed the hyperosmotic regulation of TAUT. The osmosensitive upregulation of TAUT was also significantly inhibited by calmodulin antagonists and calcium-chelators. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca2+/CaM kinase II inhibitor. The activated form of Ca2+/CaM kinase II protein could only be detected in Caco-2 cells under hypertonic conditions.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2004.05.062</identifier><identifier>PMID: 15225620</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>AR, aldose reductase ; Benzylamines - pharmacology ; BGT1, betaine/γ-amino-n-butyric acid transporter 1 ; Ca2+/CaM kinase II, calcium/calmodulin-dependent protein kinase II ; Caco-2 ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors ; Calcium-Calmodulin-Dependent Protein Kinases - metabolism ; Calcium/calmodulin-dependent protein kinase II (Ca2+/CaM kinase II) ; Carrier Proteins - biosynthesis ; Carrier Proteins - genetics ; Cell Line, Tumor ; Colonic Neoplasms ; CREB, cAMP-responsive element-binding protein ; DIDS, 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid ; DMEM, Dulbecco's modified Eagle's medium ; Enzyme Activation ; Enzyme Inhibitors - pharmacology ; ERK, extracellular signal-regulated kinase ; Et-18-OCH3, 1-O octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine ; FCS, fetal calf serum ; Flavonoids - pharmacology ; Gene Expression Regulation, Neoplastic - genetics ; HBSS, Hank's balanced salt solution ; Humans ; Imidazoles - pharmacology ; JNK, Jun N-terminal kinase ; Kinetics ; LPC, lysophosphatidylcholine ; MAP kinase, mitogen-activated protein kinase ; Membrane Glycoproteins - biosynthesis ; Membrane Glycoproteins - genetics ; Membrane Transport Proteins ; Osmolar Concentration ; Osmoregulation ; PBS, phosphate-buffered saline ; PDTC, pyrrolidine dithiocarbamate ; PKA, protein kinase A ; PKC, protein kinase C ; Pyridines - pharmacology ; RNA, Messenger - genetics ; SMIT, myo-inositol transporter ; Sulfonamides - pharmacology ; Taurine ; TAUT, taurine transporter ; Transporter</subject><ispartof>FEBS letters, 2004-07, Vol.569 (1-3), p.123-128</ispartof><rights>2004 Federation of European Biochemical Societies</rights><rights>FEBS Letters 569 (2004) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2004.05.062$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579304006738$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,3536,27903,27904,45553,45554,46387,46811,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15225620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Satsu, Hideo</creatorcontrib><creatorcontrib>Manabe, Mariko</creatorcontrib><creatorcontrib>Shimizu, Makoto</creatorcontrib><title>Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>We investigated the signaling pathways participating in hyperosmotic regulation of the human taurine transporter (TAUT) by using specific inhibitors of various intracellular signaling molecules. Among them, the specific inhibitor of calcium/calmodulin-dependent protein kinase II (Ca2+/CaM kinase II) completely repressed the hyperosmotic regulation of TAUT. The osmosensitive upregulation of TAUT was also significantly inhibited by calmodulin antagonists and calcium-chelators. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca2+/CaM kinase II inhibitor. The activated form of Ca2+/CaM kinase II protein could only be detected in Caco-2 cells under hypertonic conditions.</description><subject>AR, aldose reductase</subject><subject>Benzylamines - pharmacology</subject><subject>BGT1, betaine/γ-amino-n-butyric acid transporter 1</subject><subject>Ca2+/CaM kinase II, calcium/calmodulin-dependent protein kinase II</subject><subject>Caco-2</subject><subject>Calcium-Calmodulin-Dependent Protein Kinase Type 2</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases - metabolism</subject><subject>Calcium/calmodulin-dependent protein kinase II (Ca2+/CaM kinase II)</subject><subject>Carrier Proteins - biosynthesis</subject><subject>Carrier Proteins - genetics</subject><subject>Cell Line, Tumor</subject><subject>Colonic Neoplasms</subject><subject>CREB, cAMP-responsive element-binding protein</subject><subject>DIDS, 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid</subject><subject>DMEM, Dulbecco's modified Eagle's medium</subject><subject>Enzyme Activation</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>ERK, extracellular signal-regulated kinase</subject><subject>Et-18-OCH3, 1-O octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine</subject><subject>FCS, fetal calf serum</subject><subject>Flavonoids - pharmacology</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>HBSS, Hank's balanced salt solution</subject><subject>Humans</subject><subject>Imidazoles - pharmacology</subject><subject>JNK, Jun N-terminal kinase</subject><subject>Kinetics</subject><subject>LPC, lysophosphatidylcholine</subject><subject>MAP kinase, mitogen-activated protein kinase</subject><subject>Membrane Glycoproteins - biosynthesis</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Transport Proteins</subject><subject>Osmolar Concentration</subject><subject>Osmoregulation</subject><subject>PBS, phosphate-buffered saline</subject><subject>PDTC, pyrrolidine dithiocarbamate</subject><subject>PKA, protein kinase A</subject><subject>PKC, protein kinase C</subject><subject>Pyridines - pharmacology</subject><subject>RNA, Messenger - genetics</subject><subject>SMIT, myo-inositol transporter</subject><subject>Sulfonamides - pharmacology</subject><subject>Taurine</subject><subject>TAUT, taurine transporter</subject><subject>Transporter</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1q3DAURkVpaKZpH6FFq26CHf3Ysr0qyZA0A4Es2q6FLF0zmtqSK8kTZtdHr4aZ0F21kS76OPDdg9AnSkpKqLjZlQP0cYRUMkKqktQlEewNWtG24QWvRPsWrQihVVE3Hb9E72PckTy3tHuHLmnNWC0YWaE_tzrZvUrWO-wHvFbs-karcfJmGa0rDMzgDLiE5-ATWId_Waci4M0G24it2_txDyY_8PYwQ_Bx8snqPJtFv0LTFvB2mZTDSS3BOsApKBdnHxKED-hiUGOEj-f7Cv18uP-xfiyenr9t1rdPBfCGt4VSQETXUlKJjgrWm77n0NaaUug6ZYxQQ9OboWGaNx20rR6EULxVTV1DZSrBr9CXEzcX-b1ATHKyUcM4Kgd-iVLkwyhjOfj5HFz6CYycg51UOMjXneXA4ynwYkc4_Psn8ihG7uRZjDyKkaSWWYx8uL9j348-jjpIRYjIrTLq6wkFufneQpBRW3AajA2gkzTe_p_L_wKtqp4n</recordid><startdate>20040702</startdate><enddate>20040702</enddate><creator>Satsu, Hideo</creator><creator>Manabe, Mariko</creator><creator>Shimizu, Makoto</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20040702</creationdate><title>Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter</title><author>Satsu, Hideo ; Manabe, Mariko ; Shimizu, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e3738-aae069810469162bdbb3e85c11e99add6af7bdf72c379e88cf66a38a755e4d463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>AR, aldose reductase</topic><topic>Benzylamines - pharmacology</topic><topic>BGT1, betaine/γ-amino-n-butyric acid transporter 1</topic><topic>Ca2+/CaM kinase II, calcium/calmodulin-dependent protein kinase II</topic><topic>Caco-2</topic><topic>Calcium-Calmodulin-Dependent Protein Kinase Type 2</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases - metabolism</topic><topic>Calcium/calmodulin-dependent protein kinase II (Ca2+/CaM kinase II)</topic><topic>Carrier Proteins - biosynthesis</topic><topic>Carrier Proteins - genetics</topic><topic>Cell Line, Tumor</topic><topic>Colonic Neoplasms</topic><topic>CREB, cAMP-responsive element-binding protein</topic><topic>DIDS, 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid</topic><topic>DMEM, Dulbecco's modified Eagle's medium</topic><topic>Enzyme Activation</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>ERK, extracellular signal-regulated kinase</topic><topic>Et-18-OCH3, 1-O octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine</topic><topic>FCS, fetal calf serum</topic><topic>Flavonoids - pharmacology</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>HBSS, Hank's balanced salt solution</topic><topic>Humans</topic><topic>Imidazoles - pharmacology</topic><topic>JNK, Jun N-terminal kinase</topic><topic>Kinetics</topic><topic>LPC, lysophosphatidylcholine</topic><topic>MAP kinase, mitogen-activated protein kinase</topic><topic>Membrane Glycoproteins - biosynthesis</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Transport Proteins</topic><topic>Osmolar Concentration</topic><topic>Osmoregulation</topic><topic>PBS, phosphate-buffered saline</topic><topic>PDTC, pyrrolidine dithiocarbamate</topic><topic>PKA, protein kinase A</topic><topic>PKC, protein kinase C</topic><topic>Pyridines - pharmacology</topic><topic>RNA, Messenger - genetics</topic><topic>SMIT, myo-inositol transporter</topic><topic>Sulfonamides - pharmacology</topic><topic>Taurine</topic><topic>TAUT, taurine transporter</topic><topic>Transporter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Satsu, Hideo</creatorcontrib><creatorcontrib>Manabe, Mariko</creatorcontrib><creatorcontrib>Shimizu, Makoto</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Satsu, Hideo</au><au>Manabe, Mariko</au><au>Shimizu, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2004-07-02</date><risdate>2004</risdate><volume>569</volume><issue>1-3</issue><spage>123</spage><epage>128</epage><pages>123-128</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>We investigated the signaling pathways participating in hyperosmotic regulation of the human taurine transporter (TAUT) by using specific inhibitors of various intracellular signaling molecules. Among them, the specific inhibitor of calcium/calmodulin-dependent protein kinase II (Ca2+/CaM kinase II) completely repressed the hyperosmotic regulation of TAUT. The osmosensitive upregulation of TAUT was also significantly inhibited by calmodulin antagonists and calcium-chelators. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca2+/CaM kinase II inhibitor. The activated form of Ca2+/CaM kinase II protein could only be detected in Caco-2 cells under hypertonic conditions.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>15225620</pmid><doi>10.1016/j.febslet.2004.05.062</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | AR, aldose reductase Benzylamines - pharmacology BGT1, betaine/γ-amino-n-butyric acid transporter 1 Ca2+/CaM kinase II, calcium/calmodulin-dependent protein kinase II Caco-2 Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - metabolism Calcium/calmodulin-dependent protein kinase II (Ca2+/CaM kinase II) Carrier Proteins - biosynthesis Carrier Proteins - genetics Cell Line, Tumor Colonic Neoplasms CREB, cAMP-responsive element-binding protein DIDS, 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid DMEM, Dulbecco's modified Eagle's medium Enzyme Activation Enzyme Inhibitors - pharmacology ERK, extracellular signal-regulated kinase Et-18-OCH3, 1-O octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine FCS, fetal calf serum Flavonoids - pharmacology Gene Expression Regulation, Neoplastic - genetics HBSS, Hank's balanced salt solution Humans Imidazoles - pharmacology JNK, Jun N-terminal kinase Kinetics LPC, lysophosphatidylcholine MAP kinase, mitogen-activated protein kinase Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Transport Proteins Osmolar Concentration Osmoregulation PBS, phosphate-buffered saline PDTC, pyrrolidine dithiocarbamate PKA, protein kinase A PKC, protein kinase C Pyridines - pharmacology RNA, Messenger - genetics SMIT, myo-inositol transporter Sulfonamides - pharmacology Taurine TAUT, taurine transporter Transporter |
| title | Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter |
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