Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation
Mesenchymal chondrosarcoma is a rare malignant chondrogenic neoplasm that tends to affect young adults and teenagers. The prognosis is unpredictable, and the identification of prognostic markers that could aid in determining the behaviour of this tumour would be helpful. There are few studies in the...
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| Veröffentlicht in: | Pathology 2004-06, Vol.36 (3), p.230-233 |
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| creator | Nussbeck, W. Neureiter, D. Söder, S. Inwards, C. Aigner, T. |
| description | Mesenchymal chondrosarcoma is a rare malignant chondrogenic neoplasm that tends to affect young adults and teenagers. The prognosis is unpredictable, and the identification of prognostic markers that could aid in determining the behaviour of this tumour would be helpful. There are few studies in the literature that have attempted to address this issue.
In this study, we explored the prognostic significance of three different parameters: (1) tissue morphology of small cell areas, (2) the expression of tumour differentiation marker genes, and (3) the proliferation rate. Our results did not show a correlation of prognosis with the histological features of the neoplastic small cell areas or the expression of tumour differentiation genes. However, the proliferative activity of the tumour cells appeared to have some prognostic significance as related to patient survival.
Mesenchymal chondrosarcoma is a rare tumour with a wide clinical range of behaviour. Therefore, it is difficult to obtain reliable prognostic parameters. Nevertheless, our study suggests that proliferative activity may be a useful prognostic parameter for mesenchymal chondrosarcomas. |
| doi_str_mv | 10.1080/00313020410001716669 |
| format | Article |
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In this study, we explored the prognostic significance of three different parameters: (1) tissue morphology of small cell areas, (2) the expression of tumour differentiation marker genes, and (3) the proliferation rate. Our results did not show a correlation of prognosis with the histological features of the neoplastic small cell areas or the expression of tumour differentiation genes. However, the proliferative activity of the tumour cells appeared to have some prognostic significance as related to patient survival.
Mesenchymal chondrosarcoma is a rare tumour with a wide clinical range of behaviour. Therefore, it is difficult to obtain reliable prognostic parameters. Nevertheless, our study suggests that proliferative activity may be a useful prognostic parameter for mesenchymal chondrosarcomas.</description><identifier>ISSN: 0031-3025</identifier><identifier>EISSN: 1465-3931</identifier><identifier>DOI: 10.1080/00313020410001716669</identifier><identifier>PMID: 15203726</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Bone Neoplasms - metabolism ; Bone Neoplasms - pathology ; Cell Differentiation - physiology ; Cell Proliferation ; Chondrosarcoma, Mesenchymal - metabolism ; Chondrosarcoma, Mesenchymal - pathology ; Collagen Type II - genetics ; Collagen Type II - metabolism ; Collagen Type X - genetics ; Collagen Type X - metabolism ; Diseases of the osteoarticular system ; Female ; General aspects ; Humans ; Immunohistochemistry ; Ki-67 ; Ki-67 Antigen - metabolism ; Male ; Medical sciences ; Mesenchymal chondrosarcoma ; Middle Aged ; nuclear atypia ; Prognosis ; proliferation ; Tumors of striated muscle and skeleton</subject><ispartof>Pathology, 2004-06, Vol.36 (3), p.230-233</ispartof><rights>2004 Royal College of Pathologists of Australasia</rights><rights>2004 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2004</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-3381beef8c66fa8611ba09ecf74d3e34957dfa3632467ba47dfbd436ce26a7753</citedby><cites>FETCH-LOGICAL-c540t-3381beef8c66fa8611ba09ecf74d3e34957dfa3632467ba47dfbd436ce26a7753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00313020410001716669$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00313020410001716669$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,61219,61400</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15760319$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15203726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nussbeck, W.</creatorcontrib><creatorcontrib>Neureiter, D.</creatorcontrib><creatorcontrib>Söder, S.</creatorcontrib><creatorcontrib>Inwards, C.</creatorcontrib><creatorcontrib>Aigner, T.</creatorcontrib><title>Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation</title><title>Pathology</title><addtitle>Pathology</addtitle><description>Mesenchymal chondrosarcoma is a rare malignant chondrogenic neoplasm that tends to affect young adults and teenagers. The prognosis is unpredictable, and the identification of prognostic markers that could aid in determining the behaviour of this tumour would be helpful. There are few studies in the literature that have attempted to address this issue.
In this study, we explored the prognostic significance of three different parameters: (1) tissue morphology of small cell areas, (2) the expression of tumour differentiation marker genes, and (3) the proliferation rate. Our results did not show a correlation of prognosis with the histological features of the neoplastic small cell areas or the expression of tumour differentiation genes. However, the proliferative activity of the tumour cells appeared to have some prognostic significance as related to patient survival.
Mesenchymal chondrosarcoma is a rare tumour with a wide clinical range of behaviour. Therefore, it is difficult to obtain reliable prognostic parameters. Nevertheless, our study suggests that proliferative activity may be a useful prognostic parameter for mesenchymal chondrosarcomas.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - pathology</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Proliferation</subject><subject>Chondrosarcoma, Mesenchymal - metabolism</subject><subject>Chondrosarcoma, Mesenchymal - pathology</subject><subject>Collagen Type II - genetics</subject><subject>Collagen Type II - metabolism</subject><subject>Collagen Type X - genetics</subject><subject>Collagen Type X - metabolism</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenchymal chondrosarcoma</subject><subject>Middle Aged</subject><subject>nuclear atypia</subject><subject>Prognosis</subject><subject>proliferation</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0031-3025</issn><issn>1465-3931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkFv1DAQhSMEotvCP0DIF7gF7DhxEg5IVQUFqYgLnKNZZ7yZKrGLnVTsj-G_MtFGggOip5Hlb56f3nOWvVDyjZKNfCulVloWslRSSlUrY0z7KNup0lS5brV6nO1WJGemOsvOU7plrmya5ml2pqpC6rowu-zXF0zo7XCcYBR2CL6PIUG0YYJ3ArygaVp8GCjNwQ44kWUszUt_FMEJJYWFhEngT5jIkz-IuxgOPqSZrEh08OR4w1tcab4ayWGEme5RgOVB85Ef6YXFcVxGiKInxwT6mZgK_ln2xMGY8Pk2L7LvHz98u_qU33y9_nx1eZPbqpRzrnWj9oiuscY4aIxSe5AtWleXvUZdtlXdO9BGF6Wp91Dyad-X2lgsDNR1pS-y1ydd9vhjwTR3E6XVFHgMS-o426otOM6HQNUabVTdMFieQMt5poiuu4s0QTx2SnZrf92_-uO1l5v-sp-w_7O0FcbAqw2AxF24yOlS-ourDeuuQu9PHHkX4gQDwjgPFiJ2t2GJntN8yMkmgJz7PWHskiX-KdhTRDt3faD_C_wGek_M5g</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Nussbeck, W.</creator><creator>Neureiter, D.</creator><creator>Söder, S.</creator><creator>Inwards, C.</creator><creator>Aigner, T.</creator><general>Elsevier B.V</general><general>Informa UK Ltd</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation</title><author>Nussbeck, W. ; Neureiter, D. ; Söder, S. ; Inwards, C. ; Aigner, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-3381beef8c66fa8611ba09ecf74d3e34957dfa3632467ba47dfbd436ce26a7753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Bone Neoplasms - metabolism</topic><topic>Bone Neoplasms - pathology</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Proliferation</topic><topic>Chondrosarcoma, Mesenchymal - metabolism</topic><topic>Chondrosarcoma, Mesenchymal - pathology</topic><topic>Collagen Type II - genetics</topic><topic>Collagen Type II - metabolism</topic><topic>Collagen Type X - genetics</topic><topic>Collagen Type X - metabolism</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesenchymal chondrosarcoma</topic><topic>Middle Aged</topic><topic>nuclear atypia</topic><topic>Prognosis</topic><topic>proliferation</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nussbeck, W.</creatorcontrib><creatorcontrib>Neureiter, D.</creatorcontrib><creatorcontrib>Söder, S.</creatorcontrib><creatorcontrib>Inwards, C.</creatorcontrib><creatorcontrib>Aigner, T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nussbeck, W.</au><au>Neureiter, D.</au><au>Söder, S.</au><au>Inwards, C.</au><au>Aigner, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation</atitle><jtitle>Pathology</jtitle><addtitle>Pathology</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>36</volume><issue>3</issue><spage>230</spage><epage>233</epage><pages>230-233</pages><issn>0031-3025</issn><eissn>1465-3931</eissn><abstract>Mesenchymal chondrosarcoma is a rare malignant chondrogenic neoplasm that tends to affect young adults and teenagers. The prognosis is unpredictable, and the identification of prognostic markers that could aid in determining the behaviour of this tumour would be helpful. There are few studies in the literature that have attempted to address this issue.
In this study, we explored the prognostic significance of three different parameters: (1) tissue morphology of small cell areas, (2) the expression of tumour differentiation marker genes, and (3) the proliferation rate. Our results did not show a correlation of prognosis with the histological features of the neoplastic small cell areas or the expression of tumour differentiation genes. However, the proliferative activity of the tumour cells appeared to have some prognostic significance as related to patient survival.
Mesenchymal chondrosarcoma is a rare tumour with a wide clinical range of behaviour. Therefore, it is difficult to obtain reliable prognostic parameters. Nevertheless, our study suggests that proliferative activity may be a useful prognostic parameter for mesenchymal chondrosarcomas.</abstract><cop>London</cop><pub>Elsevier B.V</pub><pmid>15203726</pmid><doi>10.1080/00313020410001716669</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Biomarkers, Tumor - analysis Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Differentiation - physiology Cell Proliferation Chondrosarcoma, Mesenchymal - metabolism Chondrosarcoma, Mesenchymal - pathology Collagen Type II - genetics Collagen Type II - metabolism Collagen Type X - genetics Collagen Type X - metabolism Diseases of the osteoarticular system Female General aspects Humans Immunohistochemistry Ki-67 Ki-67 Antigen - metabolism Male Medical sciences Mesenchymal chondrosarcoma Middle Aged nuclear atypia Prognosis proliferation Tumors of striated muscle and skeleton |
| title | Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation |
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