Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case–control study
BACKGROUND: Obesity has become a major health problem worldwide and is also associated with adverse pregnancy outcome. The aim of this study was to assess the impact of obesity on the risk of miscarriage in the general public. METHODS: This was a nested case–control study. The study population was i...
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| Veröffentlicht in: | Human reproduction (Oxford) 2004-07, Vol.19 (7), p.1644-1646 |
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| container_title | Human reproduction (Oxford) |
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| creator | Lashen, H. Fear, K. Sturdee, D.W. |
| description | BACKGROUND: Obesity has become a major health problem worldwide and is also associated with adverse pregnancy outcome. The aim of this study was to assess the impact of obesity on the risk of miscarriage in the general public. METHODS: This was a nested case–control study. The study population was identified from a maternity database. Obese [body mass index (BMI) >30 kg/m2] women were compared with an age‐matched control group with normal BMI (19–24.9 kg/m2). Only primiparous women were included in the study to avoid including the subject more than once, and to be able to correctly identify recurrent miscarriages. The prevalence of a previous history of early (6–12 weeks gestation), late (12–24 weeks gestation) and recurrent early miscarriages (REM) (more than three successive miscarriages |
| doi_str_mv | 10.1093/humrep/deh277 |
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The aim of this study was to assess the impact of obesity on the risk of miscarriage in the general public. METHODS: This was a nested case–control study. The study population was identified from a maternity database. Obese [body mass index (BMI) >30 kg/m2] women were compared with an age‐matched control group with normal BMI (19–24.9 kg/m2). Only primiparous women were included in the study to avoid including the subject more than once, and to be able to correctly identify recurrent miscarriages. The prevalence of a previous history of early (6–12 weeks gestation), late (12–24 weeks gestation) and recurrent early miscarriages (REM) (more than three successive miscarriages <12 weeks) was compared between the two groups. RESULTS: A total of 1644 obese and 3288 age‐matched normal weight controls with a mean age of 26.6 years [95% confidence interval (CI) 26.5–26.7] were included in the study. The risks of early miscarriage and REM were significantly higher among the obese patients (odds ratios 1.2 and 3.5, 95% CI 1.01–1.46 and 1.03–12.01, respectively; P = 0.04, for both]. CONCLUSIONS: Obesity is associated with increased risk of first trimester and recurrent miscarriage.</description><identifier>ISSN: 0268-1161</identifier><identifier>ISSN: 1460-2350</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/deh277</identifier><identifier>PMID: 15142995</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Abortion, Habitual - etiology ; Abortion, Spontaneous - etiology ; Adult ; Biological and medical sciences ; Case-Control Studies ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Miscarriage ; Obesity - complications ; obesity/miscarriage/recurrent miscarriage ; Pregnancy ; Pregnancy Complications ; Pregnancy Trimester, First ; Random Allocation ; Risk Assessment</subject><ispartof>Human reproduction (Oxford), 2004-07, Vol.19 (7), p.1644-1646</ispartof><rights>European Society of Human Reproduction and Embryology 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jul 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-d0d5771c0b0376ced024915aaf877b1b14acab471a18139736ab8d89983440c93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15942841$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15142995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lashen, H.</creatorcontrib><creatorcontrib>Fear, K.</creatorcontrib><creatorcontrib>Sturdee, D.W.</creatorcontrib><title>Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case–control study</title><title>Human reproduction (Oxford)</title><addtitle>Hum. Reprod</addtitle><addtitle>Hum. Reprod</addtitle><description>BACKGROUND: Obesity has become a major health problem worldwide and is also associated with adverse pregnancy outcome. The aim of this study was to assess the impact of obesity on the risk of miscarriage in the general public. METHODS: This was a nested case–control study. The study population was identified from a maternity database. Obese [body mass index (BMI) >30 kg/m2] women were compared with an age‐matched control group with normal BMI (19–24.9 kg/m2). Only primiparous women were included in the study to avoid including the subject more than once, and to be able to correctly identify recurrent miscarriages. The prevalence of a previous history of early (6–12 weeks gestation), late (12–24 weeks gestation) and recurrent early miscarriages (REM) (more than three successive miscarriages <12 weeks) was compared between the two groups. RESULTS: A total of 1644 obese and 3288 age‐matched normal weight controls with a mean age of 26.6 years [95% confidence interval (CI) 26.5–26.7] were included in the study. The risks of early miscarriage and REM were significantly higher among the obese patients (odds ratios 1.2 and 3.5, 95% CI 1.01–1.46 and 1.03–12.01, respectively; P = 0.04, for both]. CONCLUSIONS: Obesity is associated with increased risk of first trimester and recurrent miscarriage.</description><subject>Abortion, Habitual - etiology</subject><subject>Abortion, Spontaneous - etiology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Miscarriage</subject><subject>Obesity - complications</subject><subject>obesity/miscarriage/recurrent miscarriage</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Pregnancy Trimester, First</subject><subject>Random Allocation</subject><subject>Risk Assessment</subject><issn>0268-1161</issn><issn>1460-2350</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEUhYMoTtu6dCtBUNyUk1uVn4o7aUZbHBgQBXETbqVSdmaqq3qSFE7vfAff0CcxQxUqblzlhnz35HAOIY-BvQSmq9PdtA_ucNq6XanUHbICLllRVoLdJStWyroAkHBCHsR4yVgea3mfnIAAXmotViRdNC76dKQ-UoxxtB6Ta-k3n3bUDzY4jPkafLyiY0c7H2KiKfi9i8kFikN-c3YKwQ2J7n20GILHr-4V3WOyu7xqs8DP7z_sOKQw9jSmqT0-JPc67KN7tJxr8unN2cfNtji_ePtu8_q8sFzIVLSsFUqBZQ2rlLSuZSXXIBC7WqkGGuBoseEKEGqotKokNnVba11XnDOrqzV5Pusewng9Zcvm1qLrexzcOEUjpRRKapbBp_-Al-MUhuzNlAC1kDyrr0kxQzaMMQbXmUMOAsPRADO3XZi5CzN3kfkni-jU7F37h17Cz8CzBcAcXN8FHKyPf3GalzWHzL2YuXE6_PfPxaPP_dz8hjFcGakqJcz28xcjeLmFD--52VS_AODfsso</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>Lashen, H.</creator><creator>Fear, K.</creator><creator>Sturdee, D.W.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040701</creationdate><title>Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case–control study</title><author>Lashen, H. ; Fear, K. ; Sturdee, D.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-d0d5771c0b0376ced024915aaf877b1b14acab471a18139736ab8d89983440c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Abortion, Habitual - etiology</topic><topic>Abortion, Spontaneous - etiology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Miscarriage</topic><topic>Obesity - complications</topic><topic>obesity/miscarriage/recurrent miscarriage</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Pregnancy Trimester, First</topic><topic>Random Allocation</topic><topic>Risk Assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lashen, H.</creatorcontrib><creatorcontrib>Fear, K.</creatorcontrib><creatorcontrib>Sturdee, D.W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lashen, H.</au><au>Fear, K.</au><au>Sturdee, D.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case–control study</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum. Reprod</stitle><addtitle>Hum. Reprod</addtitle><date>2004-07-01</date><risdate>2004</risdate><volume>19</volume><issue>7</issue><spage>1644</spage><epage>1646</epage><pages>1644-1646</pages><issn>0268-1161</issn><issn>1460-2350</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND: Obesity has become a major health problem worldwide and is also associated with adverse pregnancy outcome. The aim of this study was to assess the impact of obesity on the risk of miscarriage in the general public. METHODS: This was a nested case–control study. The study population was identified from a maternity database. Obese [body mass index (BMI) >30 kg/m2] women were compared with an age‐matched control group with normal BMI (19–24.9 kg/m2). Only primiparous women were included in the study to avoid including the subject more than once, and to be able to correctly identify recurrent miscarriages. The prevalence of a previous history of early (6–12 weeks gestation), late (12–24 weeks gestation) and recurrent early miscarriages (REM) (more than three successive miscarriages <12 weeks) was compared between the two groups. RESULTS: A total of 1644 obese and 3288 age‐matched normal weight controls with a mean age of 26.6 years [95% confidence interval (CI) 26.5–26.7] were included in the study. The risks of early miscarriage and REM were significantly higher among the obese patients (odds ratios 1.2 and 3.5, 95% CI 1.01–1.46 and 1.03–12.01, respectively; P = 0.04, for both]. CONCLUSIONS: Obesity is associated with increased risk of first trimester and recurrent miscarriage.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15142995</pmid><doi>10.1093/humrep/deh277</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abortion, Habitual - etiology Abortion, Spontaneous - etiology Adult Biological and medical sciences Case-Control Studies Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Humans Miscarriage Obesity - complications obesity/miscarriage/recurrent miscarriage Pregnancy Pregnancy Complications Pregnancy Trimester, First Random Allocation Risk Assessment |
| title | Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case–control study |
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