Behavioral effects of CD40–CD40L pathway disruption in aged PSAPP mice

We have shown that, when an amyloid-beta peptide (Aβ) overproducing transgenic mouse model (PSAPP) of Alzheimer's disease (AD) is treated with a depleting antibody against CD40L, it causes marked attenuation of Aβ pathology associated with decreased amyloidogenic processing of amyloid precursor...

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Veröffentlicht in:	Brain research 2004-07, Vol.1015 (1), p.161-168
Hauptverfasser:	Todd Roach, J, Volmar, Claude-Henry, Dwivedi, Samvid, Town, Terrence, Crescentini, Robert, Crawford, Fiona, Tan, Jun, Mullan, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Alzheimer Disease - genetics Alzheimer Disease - immunology Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid precursor protein Animals Behavior Behavior, Animal - physiology Biological and medical sciences CD40 CD40 Antigens - immunology CD40 Antigens - metabolism CD40 Ligand - immunology CD40 Ligand - metabolism Cognition - physiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Female Male Maze Learning - physiology Medical sciences Memory - physiology Mice Mice, Transgenic Mouse Neurology Psychomotor Performance - physiology Spatial Behavior - physiology Transgenic
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