Platelet 12-Lipoxygenase Activation via Glycoprotein VI: Involvement of Multiple Signaling Pathways in Agonist Control of H(P)ETE Synthesis

Lipoxygenases (LOX) contribute to vascular disease and inflammation through generation of bioactive lipids, including 12-hydro(pero)xyeicosatetraenoic acid (12-H(P)ETE). The physiological mechanisms that acutely control LOX product generation in mammalian cells are uncharacterized. Human platelets t...

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Veröffentlicht in:	Circulation research 2004-06, Vol.94 (12), p.1598-1605
Hauptverfasser:	Coffey, Marcus J, Jarvis, Gavin E, Gibbins, Jonathan M, Coles, Barbara, Barrett, Natasha E, Wylie, Oliver R.E, O’Donnell, Valerie B
Format:	Artikel
Sprache:	eng
Schlagworte:	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - biosynthesis 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - blood 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Adenosine Diphosphate - pharmacology Amino Acid Motifs Arachidonate 12-Lipoxygenase - blood Arachidonate 12-Lipoxygenase - metabolism Arachidonic Acid - pharmacology Blood Platelets - drug effects Blood Platelets - enzymology Calcimycin - pharmacology Calcium Signaling - drug effects Carrier Proteins - pharmacology Collagen - pharmacology Cyclooxygenase 1 Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Humans Inflammation - immunology Isoenzymes - physiology Leukotrienes - biosynthesis Leukotrienes - blood Leukotrienes - secretion Membrane Proteins p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - physiology Peptides - pharmacology Phosphorylation - drug effects Platelet Activation - drug effects Platelet Endothelial Cell Adhesion Molecule-1 - physiology Platelet Membrane Glycoproteins - physiology Prostaglandin-Endoperoxide Synthases - physiology Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Protein Processing, Post-Translational - drug effects Protein Transport - drug effects Quinolines - pharmacology Receptors, IgG - physiology Thrombin - pharmacology
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