Quantitative determination of zidovudine diaryl phosphate triester pro-drugs in rat plasma by high-performance liquid chromatography–electrospray ionization tandem mass spectrometry

A rapid, simple, and sensitive high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ESI–MS/MS) method was developed and validated for quantitative analysis of 3′-azido-3′-deoxythymidine (zidovudine, AZT) diaryl phosphate triester pro-drugs, in rat plasma usin...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2008-12, Vol.48 (5), p.1417-1424
Hauptverfasser:	Zhu, Meixiang, Xie, Baoying, Tang, Guo, Hu, Anfu, Fang, Meijuan, Wu, Zhen, Zhao, Yufen
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals Anti-HIV Agents - blood Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - standards Area Under Curve Biological and medical sciences Calibration Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Diaryl phosphate triesters of zidovudine Drug Stability Female Freezing Fundamental and applied biological sciences. Psychology General pharmacology Half-Life Male Medical sciences Molecular Structure Molecular Weight Multiple reaction monitoring Pharmacology. Drug treatments Pro-drugs Prodrugs - chemistry Quality Control Quantitative determination Rat plasma Rats Rats, Sprague-Dawley Reference Standards Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry - methods Time Factors Zidovudine - blood Zidovudine - chemistry Zidovudine - pharmacokinetics Zidovudine - standards
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