BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas

Somatic mutations of the BRAF gene (BRAFV599E and BRAFK600E) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is appa...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2004-06, Vol.444 (6), p.572-576
Hauptverfasser:	SOARES, Paula, TROVISCO, Vitor, ROCHA, Ana Sofia, FEIJAO, Talia, REBOCHO, Ana Paula, FONSECA, Elsa, VIEIRA DE CASTRO, Inês, CAMESELLE-TEIJEIRO, José, CARDOSO-OLIVEIRA, Manuel, SOBRINHO-SIMOES, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Papillary - genetics Adenocarcinoma, Papillary - pathology Biological and medical sciences Cell Transformation, Neoplastic DNA Mutational Analysis DNA, Neoplasm - analysis Endocrinopathies Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mutation Non tumoral diseases. Target tissue resistance. Benign neoplasms Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Proto-Oncogene Proteins B-raf Proto-Oncogene Proteins c-raf - genetics Thyroid Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Thyroid. Thyroid axis (diseases)
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