Rapid assay of topiramate in dried blood spots by a new liquid chromatography-tandem mass spectrometric method

Topiramate (TPM) is a new antiepiletic drug with efficacy in several types of seizures. Therapeutic drug monitoring of TPM is essential for effective patient management. The aim of this study was to evaluate the use of dried blood spot (DBS) specimens to determinate the TPM levels during the treatme...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2008-12, Vol.48 (5), p.1392-1396
Hauptverfasser:	la Marca, Giancarlo, Malvagia, Sabrina, Filippi, Luca, Fiorini, Patrizio, Innocenti, Marzia, Luceri, Francesca, Pieraccini, Giuseppe, Moneti, Gloriano, Francese, Simona, Dani, Francesca Romana, Guerrini, Renzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Anticonvulsant Anticonvulsants - analysis Anticonvulsants - chemistry Biological and medical sciences Biological Assay - methods Blood Specimen Collection - methods Calibration Case-Control Studies Chromatography, Liquid - methods Desiccation - methods Epilepsy Epilepsy - blood Fluorescence Polarization - methods Fluorescence polarization immunoassay (FPIA) Fructose - analogs & derivatives Fructose - analysis Fructose - chemistry Fundamental and applied biological sciences. Psychology General pharmacology Humans Immunoassay Liquid chromatography-tandem mass spectrometry Medical sciences Molecular Structure Pharmacology. Drug treatments Reference Standards Sensitivity and Specificity Tandem Mass Spectrometry - methods Time Factors Topiramate
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