Angiotensin II AT1 receptor blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously hypertensive rats

The spontaneously hypertensive rat (SHR) is vulnerable to brain ischemia and stress and exhibits a chronically stimulated brain angiotensin II system, cerebrovascular hypertrophy, and inflammation. Pretreatment with angiotensin II type 1 (AT1) receptor antagonists protects from brain ischemia and fr...

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Veröffentlicht in:	Stroke (1970) 2004-07, Vol.35 (7), p.1726-1731
Hauptverfasser:	ANDO, Hiromichi, JIN ZHOU, MACOVA, Miroslava, IMBODEN, Hans, SAAVEDRA, Juan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers Animals Anti-Inflammatory Agents - pharmacology Benzimidazoles - pharmacology Biological and medical sciences Brain - blood supply Brain - pathology Brain Ischemia - prevention & control Carotid Arteries - drug effects Carotid Arteries - metabolism Hypertrophy Inflammation Intercellular Adhesion Molecule-1 - metabolism Macrophage Activation Male Medical sciences Microcirculation - drug effects Microcirculation - metabolism Neurology Neuroprotective Agents - pharmacology Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Rats Rats, Inbred SHR Rats, Inbred WKY Tetrazoles - pharmacology Vascular diseases and vascular malformations of the nervous system
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