A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes

A novel oxyiminoalkanoic acid derivative, TAK-559, ( E)-4-[4-[(5-methyl-2-phenyl-1, 3-oxazol-4-yl)methoxy]benzyloxyimino]-4-phenylbutyric acid, was synthesized as a candidate of a new type of insulin-sensitizing agent. We report here activation of human peroxisome proliferator-activated receptor (hP...

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Veröffentlicht in:	European journal of pharmacology 2004-07, Vol.495 (1), p.17-26
Hauptverfasser:	Sakamoto, Junichi, Kimura, Hiroyuki, Moriyama, Shinji, Imoto, Hiroshi, Momose, Yu, Odaka, Hiroyuki, Sawada, Hidekazu
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adipocytes - drug effects Adipocytes - metabolism Animals Biological and medical sciences Butyrates - metabolism Butyrates - pharmacology Cercopithecus aethiops COS Cells DNA-Binding Proteins - drug effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods Dual agonist Histone Acetyltransferases Humans Hypoglycemic Agents - metabolism Hypoglycemic Agents - pharmacology Japan Medical sciences Mice Nuclear Receptor Coactivator 1 Oxazoles - metabolism Oxazoles - pharmacology Partial agonist Peroxisome proliferator-activated receptor Pharmacology. Drug treatments PPAR gamma - drug effects PPAR gamma - genetics RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism TAK-559 Thiazolidinediones - pharmacology Transcription Factor AP-2 Transcription Factors - drug effects Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - pharmacology Transfection
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