Effects of dietary medium-chain triacylglycerol on mRNA level of gluconeogenic enzymes in malnourished rats
We have reported previously that dietary medium-chain triacylglycerol (MCT) improved serum albumin concentration and protein balance in malnourished rats. To clarify the mechanisms for this effect of MCT, hepatic messenger RNA levels of gluconeogenic enzymes, pyruvate dehydrogenase (PDH) and alanine...
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| description | We have reported previously that dietary medium-chain triacylglycerol (MCT) improved serum albumin concentration and protein balance in malnourished rats. To clarify the mechanisms for this effect of MCT, hepatic messenger RNA levels of gluconeogenic enzymes, pyruvate dehydrogenase (PDH) and alanine aminotransferase (ALT) were measured in rats fed low-protein diets containing either MCT or isocaloric long-chain triacylglycerol (LCT) for 2 wk. The serum albumin concentration in rats fed the MCT diet was significantly higher compared with those fed the LCT diet. Serum free fatty acids and ketone body fraction were higher in rats fed MCT compared with those fed the LCT diet. The hepatic mRNA level of PDH was significantly lower in rats fed MCT than those fed LCT. But, there was no significant difference between the two groups in mRNA of gluconeogenic enzymes or ALT. These results suggest that ketone bodies, which are an alternative energy source and might spare blood glucose, increase by MCT feeding, and the reason for the PEM (protein-energy malnutrition)-improving effect of MCT is not caused by suppression of gluconeogenesis. |
| doi_str_mv | 10.3177/jnsv.54.507 |
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Research Lab.) ; Kasai, M</creator><creatorcontrib>Kojima, K.(Nisshin Oillio Group Ltd., Yokohama (Japan). Research Lab.) ; Kasai, M</creatorcontrib><description>We have reported previously that dietary medium-chain triacylglycerol (MCT) improved serum albumin concentration and protein balance in malnourished rats. To clarify the mechanisms for this effect of MCT, hepatic messenger RNA levels of gluconeogenic enzymes, pyruvate dehydrogenase (PDH) and alanine aminotransferase (ALT) were measured in rats fed low-protein diets containing either MCT or isocaloric long-chain triacylglycerol (LCT) for 2 wk. The serum albumin concentration in rats fed the MCT diet was significantly higher compared with those fed the LCT diet. Serum free fatty acids and ketone body fraction were higher in rats fed MCT compared with those fed the LCT diet. The hepatic mRNA level of PDH was significantly lower in rats fed MCT than those fed LCT. But, there was no significant difference between the two groups in mRNA of gluconeogenic enzymes or ALT. These results suggest that ketone bodies, which are an alternative energy source and might spare blood glucose, increase by MCT feeding, and the reason for the PEM (protein-energy malnutrition)-improving effect of MCT is not caused by suppression of gluconeogenesis.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.54.507</identifier><identifier>PMID: 19155591</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>ACIDE GRAS ; ACIDOS GRASOS ; Actins - genetics ; Actins - metabolism ; Adipose Tissue - drug effects ; Alanine Transaminase - blood ; ALIMENTACION ; ALIMENTATION ; Animals ; ARN MENSAJERO ; ARN MESSAGER ; Biological and medical sciences ; Blood Proteins - metabolism ; Brassica rapa ; DIET ; DIETA ; Dietary Fats - pharmacology ; ENZIMAS ; ENZYME ; ENZYMES ; FATTY ACIDS ; Fatty Acids, Nonesterified - blood ; FEEDING ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; GLUCONEOGENESE ; GLUCONEOGENESIS ; Ketone Bodies - blood ; LARGURA ; LENGTH ; Liver - drug effects ; Liver - enzymology ; LONGUEUR ; MALNUTRICION ; MALNUTRITION ; medium-chain triacylglycerol ; MESSENGER RNA ; Plant Oils - pharmacology ; protein-energy malnutrition ; Protein-Energy Malnutrition - drug therapy ; Protein-Energy Malnutrition - enzymology ; Pyruvate Dehydrogenase Complex - blood ; RAT ; RATA ; RATS ; REGIME ALIMENTAIRE ; RNA, Messenger - metabolism ; TRIGLICERIDOS ; TRIGLYCERIDE ; TRIGLYCERIDES ; Triglycerides - pharmacology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Weight Gain - drug effects</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2008, Vol.54(6), pp.507-510</ispartof><rights>2008 by the Center for Academic Publications Japan</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c636t-fcce9ebf2ffea5cf2f12079efaff5cb16f50da1f958cfaed279e1dd8a5284bbb3</citedby><cites>FETCH-LOGICAL-c636t-fcce9ebf2ffea5cf2f12079efaff5cb16f50da1f958cfaed279e1dd8a5284bbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1882,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21089138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19155591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kojima, K.(Nisshin Oillio Group Ltd., Yokohama (Japan). Research Lab.)</creatorcontrib><creatorcontrib>Kasai, M</creatorcontrib><title>Effects of dietary medium-chain triacylglycerol on mRNA level of gluconeogenic enzymes in malnourished rats</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>We have reported previously that dietary medium-chain triacylglycerol (MCT) improved serum albumin concentration and protein balance in malnourished rats. To clarify the mechanisms for this effect of MCT, hepatic messenger RNA levels of gluconeogenic enzymes, pyruvate dehydrogenase (PDH) and alanine aminotransferase (ALT) were measured in rats fed low-protein diets containing either MCT or isocaloric long-chain triacylglycerol (LCT) for 2 wk. The serum albumin concentration in rats fed the MCT diet was significantly higher compared with those fed the LCT diet. Serum free fatty acids and ketone body fraction were higher in rats fed MCT compared with those fed the LCT diet. The hepatic mRNA level of PDH was significantly lower in rats fed MCT than those fed LCT. But, there was no significant difference between the two groups in mRNA of gluconeogenic enzymes or ALT. These results suggest that ketone bodies, which are an alternative energy source and might spare blood glucose, increase by MCT feeding, and the reason for the PEM (protein-energy malnutrition)-improving effect of MCT is not caused by suppression of gluconeogenesis.</description><subject>ACIDE GRAS</subject><subject>ACIDOS GRASOS</subject><subject>Actins - genetics</subject><subject>Actins - metabolism</subject><subject>Adipose Tissue - drug effects</subject><subject>Alanine Transaminase - blood</subject><subject>ALIMENTACION</subject><subject>ALIMENTATION</subject><subject>Animals</subject><subject>ARN MENSAJERO</subject><subject>ARN MESSAGER</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - metabolism</subject><subject>Brassica rapa</subject><subject>DIET</subject><subject>DIETA</subject><subject>Dietary Fats - pharmacology</subject><subject>ENZIMAS</subject><subject>ENZYME</subject><subject>ENZYMES</subject><subject>FATTY ACIDS</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>FEEDING</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLUCONEOGENESE</subject><subject>GLUCONEOGENESIS</subject><subject>Ketone Bodies - blood</subject><subject>LARGURA</subject><subject>LENGTH</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>LONGUEUR</subject><subject>MALNUTRICION</subject><subject>MALNUTRITION</subject><subject>medium-chain triacylglycerol</subject><subject>MESSENGER RNA</subject><subject>Plant Oils - pharmacology</subject><subject>protein-energy malnutrition</subject><subject>Protein-Energy Malnutrition - drug therapy</subject><subject>Protein-Energy Malnutrition - enzymology</subject><subject>Pyruvate Dehydrogenase Complex - blood</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>REGIME ALIMENTAIRE</subject><subject>RNA, Messenger - metabolism</subject><subject>TRIGLICERIDOS</subject><subject>TRIGLYCERIDE</subject><subject>TRIGLYCERIDES</subject><subject>Triglycerides - pharmacology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Weight Gain - drug effects</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EotvCiTPIF7igLLYTJ86Nqmr5UAUIwdmaOOPUi-MUO6m0_PV4tdFy5GDPYX7zZvQeIS8425a8ad7tQnrYymorWfOIbLhSvGiaSjwmG1YyXlSKsTNyntKOsapVlXpKznjLpZQt35Bf19aimROdLO0dzhD3dMTeLWNh7sAFOkcHZu8HvzcYJ0-nQMfvXy6pxwf0h6nBL2YKOA0YnKEY_uxHTDRPjuDDtESX7rCnEeb0jDyx4BM-X-sF-Xlz_ePqY3H79cOnq8vbwtRlPRfWGGyxsyJfBtLkygVrWrRgrTQdr61kPXDbSmUsYC9yj_e9AilU1XVdeUHeHHXv4_R7wTTr0SWD3kM-c0m6rmtZ1lz-FxRcVK2oD-DbI2jilFJEq--jG7NXmjN9CEEfQtCy0jmETL9aZZcue_mPXV3PwOsVgGTA2wjBuHTiBGcqUypz74_cLs0w4AmAODvj8bS0Xj_WnFo5vKgxZImXRwkLk4Yhp6E_fxOMtSw_3pZ_AcCXs8o</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Kojima, K.(Nisshin Oillio Group Ltd., Yokohama (Japan). Research Lab.)</creator><creator>Kasai, M</creator><general>Center for Academic Publications Japan</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Effects of dietary medium-chain triacylglycerol on mRNA level of gluconeogenic enzymes in malnourished rats</title><author>Kojima, K.(Nisshin Oillio Group Ltd., Yokohama (Japan). Research Lab.) ; Kasai, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c636t-fcce9ebf2ffea5cf2f12079efaff5cb16f50da1f958cfaed279e1dd8a5284bbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>ACIDE GRAS</topic><topic>ACIDOS GRASOS</topic><topic>Actins - genetics</topic><topic>Actins - metabolism</topic><topic>Adipose Tissue - drug effects</topic><topic>Alanine Transaminase - blood</topic><topic>ALIMENTACION</topic><topic>ALIMENTATION</topic><topic>Animals</topic><topic>ARN MENSAJERO</topic><topic>ARN MESSAGER</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - metabolism</topic><topic>Brassica rapa</topic><topic>DIET</topic><topic>DIETA</topic><topic>Dietary Fats - pharmacology</topic><topic>ENZIMAS</topic><topic>ENZYME</topic><topic>ENZYMES</topic><topic>FATTY ACIDS</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>FEEDING</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLUCONEOGENESE</topic><topic>GLUCONEOGENESIS</topic><topic>Ketone Bodies - blood</topic><topic>LARGURA</topic><topic>LENGTH</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>LONGUEUR</topic><topic>MALNUTRICION</topic><topic>MALNUTRITION</topic><topic>medium-chain triacylglycerol</topic><topic>MESSENGER RNA</topic><topic>Plant Oils - pharmacology</topic><topic>protein-energy malnutrition</topic><topic>Protein-Energy Malnutrition - drug therapy</topic><topic>Protein-Energy Malnutrition - enzymology</topic><topic>Pyruvate Dehydrogenase Complex - blood</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>REGIME ALIMENTAIRE</topic><topic>RNA, Messenger - metabolism</topic><topic>TRIGLICERIDOS</topic><topic>TRIGLYCERIDE</topic><topic>TRIGLYCERIDES</topic><topic>Triglycerides - pharmacology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Weight Gain - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kojima, K.(Nisshin Oillio Group Ltd., Yokohama (Japan). Research Lab.)</creatorcontrib><creatorcontrib>Kasai, M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kojima, K.(Nisshin Oillio Group Ltd., Yokohama (Japan). Research Lab.)</au><au>Kasai, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dietary medium-chain triacylglycerol on mRNA level of gluconeogenic enzymes in malnourished rats</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>54</volume><issue>6</issue><spage>507</spage><epage>510</epage><pages>507-510</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>We have reported previously that dietary medium-chain triacylglycerol (MCT) improved serum albumin concentration and protein balance in malnourished rats. To clarify the mechanisms for this effect of MCT, hepatic messenger RNA levels of gluconeogenic enzymes, pyruvate dehydrogenase (PDH) and alanine aminotransferase (ALT) were measured in rats fed low-protein diets containing either MCT or isocaloric long-chain triacylglycerol (LCT) for 2 wk. The serum albumin concentration in rats fed the MCT diet was significantly higher compared with those fed the LCT diet. Serum free fatty acids and ketone body fraction were higher in rats fed MCT compared with those fed the LCT diet. The hepatic mRNA level of PDH was significantly lower in rats fed MCT than those fed LCT. But, there was no significant difference between the two groups in mRNA of gluconeogenic enzymes or ALT. These results suggest that ketone bodies, which are an alternative energy source and might spare blood glucose, increase by MCT feeding, and the reason for the PEM (protein-energy malnutrition)-improving effect of MCT is not caused by suppression of gluconeogenesis.</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>19155591</pmid><doi>10.3177/jnsv.54.507</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ACIDE GRAS ACIDOS GRASOS Actins - genetics Actins - metabolism Adipose Tissue - drug effects Alanine Transaminase - blood ALIMENTACION ALIMENTATION Animals ARN MENSAJERO ARN MESSAGER Biological and medical sciences Blood Proteins - metabolism Brassica rapa DIET DIETA Dietary Fats - pharmacology ENZIMAS ENZYME ENZYMES FATTY ACIDS Fatty Acids, Nonesterified - blood FEEDING Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology GLUCONEOGENESE GLUCONEOGENESIS Ketone Bodies - blood LARGURA LENGTH Liver - drug effects Liver - enzymology LONGUEUR MALNUTRICION MALNUTRITION medium-chain triacylglycerol MESSENGER RNA Plant Oils - pharmacology protein-energy malnutrition Protein-Energy Malnutrition - drug therapy Protein-Energy Malnutrition - enzymology Pyruvate Dehydrogenase Complex - blood RAT RATA RATS REGIME ALIMENTAIRE RNA, Messenger - metabolism TRIGLICERIDOS TRIGLYCERIDE TRIGLYCERIDES Triglycerides - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems Weight Gain - drug effects |
| title | Effects of dietary medium-chain triacylglycerol on mRNA level of gluconeogenic enzymes in malnourished rats |
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