Nitric oxide and arterial disease
Nitric oxide (NO) is a molecule that has gained recognition as a crucial modulator of vascular disease. NO has a number of intracellular effects that lead to vasorelaxation, endothelial regeneration, inhibition of leukocyte chemotaxis, and platelet adhesion. Its role in vascular disease has been int...
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| Veröffentlicht in: | Journal of Vascular Surgery 2004-07, Vol.40 (1), p.187-193 |
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| container_title | Journal of Vascular Surgery |
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| creator | Barbato, Joel E. Tzeng, Edith |
| description | Nitric oxide (NO) is a molecule that has gained recognition as a crucial modulator of vascular disease. NO has a number of intracellular effects that lead to vasorelaxation, endothelial regeneration, inhibition of leukocyte chemotaxis, and platelet adhesion. Its role in vascular disease has been intensively investigated and further elucidated over the past two decades. It is important in the pathogenesis of many cardiovascular diseases, including atherosclerosis, intimal hyperplasia, and aneurysmal disease. In addition, NO has been used as a therapeutic tool to treat diseases that range from recurrent stenosis to inhibiting thrombotic events. Many commonly used medications have their therapeutic actions through the production of NO. This review highlights the vascular biologic characteristics of NO, its role in the pathogenesis of cardiovascular disease processes, and its potential therapeutic applications. |
| doi_str_mv | 10.1016/j.jvs.2004.03.043 |
| format | Article |
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NO has a number of intracellular effects that lead to vasorelaxation, endothelial regeneration, inhibition of leukocyte chemotaxis, and platelet adhesion. Its role in vascular disease has been intensively investigated and further elucidated over the past two decades. It is important in the pathogenesis of many cardiovascular diseases, including atherosclerosis, intimal hyperplasia, and aneurysmal disease. In addition, NO has been used as a therapeutic tool to treat diseases that range from recurrent stenosis to inhibiting thrombotic events. Many commonly used medications have their therapeutic actions through the production of NO. 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NO has a number of intracellular effects that lead to vasorelaxation, endothelial regeneration, inhibition of leukocyte chemotaxis, and platelet adhesion. Its role in vascular disease has been intensively investigated and further elucidated over the past two decades. It is important in the pathogenesis of many cardiovascular diseases, including atherosclerosis, intimal hyperplasia, and aneurysmal disease. In addition, NO has been used as a therapeutic tool to treat diseases that range from recurrent stenosis to inhibiting thrombotic events. Many commonly used medications have their therapeutic actions through the production of NO. 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| ispartof | Journal of Vascular Surgery, 2004-07, Vol.40 (1), p.187-193 |
| issn | 0741-5214 1097-6809 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB* |
| subjects | Animals Biological and medical sciences Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology Humans Hyperplasia Medical sciences Neovascularization, Physiologic - drug effects Nitric Oxide - metabolism Nitric Oxide - physiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thrombosis - physiopathology Tunica Intima - pathology Tunica Intima - physiopathology Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels |
| title | Nitric oxide and arterial disease |
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