Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats

Erythropoietin (EPO) promotes proliferation and differentiation of erythroid progenitors and the survival of maturing erythroid cells. Here, we investigated the role of EPO in brain repair after stroke. Rats were treated with recombinant human EPO (rhEPO) at 24 hours after the onset of embolic strok...

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Veröffentlicht in:	Stroke (1970) 2004-07, Vol.35 (7), p.1732-1737
Hauptverfasser:	LEI WANG, ZHENGGANG ZHANG, YING WANG, RUILAN ZHANG, CHOPP, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inducing Agents - pharmacology Animals Biological and medical sciences Brain - blood supply Brain - drug effects Brain - metabolism Brain-Derived Neurotrophic Factor - metabolism Erythropoietin - pharmacology Erythropoietin - therapeutic use Infarction, Middle Cerebral Artery Male Medical sciences Microcirculation - drug effects Models, Animal Neovascularization, Physiologic - drug effects Nerve Regeneration - drug effects Neurology Neuronal Plasticity - drug effects Rats Rats, Wistar Recombinant Proteins Stroke - drug therapy Vascular diseases and vascular malformations of the nervous system Vascular Endothelial Growth Factor A - metabolism
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