3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects
To determine the in vivo feasibility of quantifying early degenerative changes in patellofemoral joint of symptomatic human knee using spin-lattice relaxation time in the rotating frame (T(1rho)) magnetic resonance imaging (MRI). All the MRI experiments were performed on a 1.5 T whole-body GE Signa...
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| Veröffentlicht in: | Academic radiology 2004-07, Vol.11 (7), p.741-749 |
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| creator | Regatte, Ravinder Reddy Akella, Sarma V S Wheaton, Andrew J Lech, Gwen Borthakur, Arijitt Kneeland, J Bruce Reddy, Ravinder |
| description | To determine the in vivo feasibility of quantifying early degenerative changes in patellofemoral joint of symptomatic human knee using spin-lattice relaxation time in the rotating frame (T(1rho)) magnetic resonance imaging (MRI).
All the MRI experiments were performed on a 1.5 T whole-body GE Signa clinical scanner using a custom built 15-cm diameter transmit-receive quadrature birdcage radiofrequency coil. The T(1rho)-prepared magnetization was imaged with a three-dimensional gradient-echo pulse sequence pre-encoded with a three-pulse cluster consisting of two hard 90 degrees pulses and a low power spin-lock pulse. Quantitative T(1rho) relaxation maps of asymptomatic (n = 8 males), and six symptomatic human volunteers (four men, two women) were computed using a appropriate signal expression.
All six symptomatic volunteers showed elevation in T(1rho) relaxation times when compared with asymptomatic subjects. In symptomatic population, the T(1rho) relaxation times varied from 63 +/- 4 ms to 95 +/- 12 ms (mean +/- standard deviation) depending on the degree of cartilage degeneration. The increase in T(1rho) of symptomatic population was statistically significant (n = 6, P |
| doi_str_mv | 10.1016/j.acra.2004.03.051 |
| format | Article |
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All the MRI experiments were performed on a 1.5 T whole-body GE Signa clinical scanner using a custom built 15-cm diameter transmit-receive quadrature birdcage radiofrequency coil. The T(1rho)-prepared magnetization was imaged with a three-dimensional gradient-echo pulse sequence pre-encoded with a three-pulse cluster consisting of two hard 90 degrees pulses and a low power spin-lock pulse. Quantitative T(1rho) relaxation maps of asymptomatic (n = 8 males), and six symptomatic human volunteers (four men, two women) were computed using a appropriate signal expression.
All six symptomatic volunteers showed elevation in T(1rho) relaxation times when compared with asymptomatic subjects. In symptomatic population, the T(1rho) relaxation times varied from 63 +/- 4 ms to 95 +/- 12 ms (mean +/- standard deviation) depending on the degree of cartilage degeneration. The increase in T(1rho) of symptomatic population was statistically significant (n = 6, P <.002) when compared with corresponding asymptomatic population. However, in asymptomatic population the relaxation times varied only from approximately 45 to 55 ms (n = 8, age range 22-45 years).
Preliminary results demonstrated the in vivo feasibility of quantifying early biochemical changes in symptomatic osteoarthritis subjects employing T(1rho)-weighted MRI on a 1.5 T clinical scanner. This study on limited number of symptomatic population shows that T(1rho)-weighted MRI provides a noninvasive marker for quantitation of early degenerative changes of cartilage in vivo. However, further studies are needed to correlate early osteoarthritis determined from arthroscopy with T(1rho) in a large symptomatic population.</description><identifier>ISSN: 1076-6332</identifier><identifier>DOI: 10.1016/j.acra.2004.03.051</identifier><identifier>PMID: 15217591</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Cartilage, Articular - pathology ; Female ; Femur - pathology ; Humans ; Knee Joint - pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Osteoarthritis, Knee - diagnosis ; Patella - pathology</subject><ispartof>Academic radiology, 2004-07, Vol.11 (7), p.741-749</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15217591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Regatte, Ravinder Reddy</creatorcontrib><creatorcontrib>Akella, Sarma V S</creatorcontrib><creatorcontrib>Wheaton, Andrew J</creatorcontrib><creatorcontrib>Lech, Gwen</creatorcontrib><creatorcontrib>Borthakur, Arijitt</creatorcontrib><creatorcontrib>Kneeland, J Bruce</creatorcontrib><creatorcontrib>Reddy, Ravinder</creatorcontrib><title>3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects</title><title>Academic radiology</title><addtitle>Acad Radiol</addtitle><description>To determine the in vivo feasibility of quantifying early degenerative changes in patellofemoral joint of symptomatic human knee using spin-lattice relaxation time in the rotating frame (T(1rho)) magnetic resonance imaging (MRI).
All the MRI experiments were performed on a 1.5 T whole-body GE Signa clinical scanner using a custom built 15-cm diameter transmit-receive quadrature birdcage radiofrequency coil. The T(1rho)-prepared magnetization was imaged with a three-dimensional gradient-echo pulse sequence pre-encoded with a three-pulse cluster consisting of two hard 90 degrees pulses and a low power spin-lock pulse. Quantitative T(1rho) relaxation maps of asymptomatic (n = 8 males), and six symptomatic human volunteers (four men, two women) were computed using a appropriate signal expression.
All six symptomatic volunteers showed elevation in T(1rho) relaxation times when compared with asymptomatic subjects. In symptomatic population, the T(1rho) relaxation times varied from 63 +/- 4 ms to 95 +/- 12 ms (mean +/- standard deviation) depending on the degree of cartilage degeneration. The increase in T(1rho) of symptomatic population was statistically significant (n = 6, P <.002) when compared with corresponding asymptomatic population. However, in asymptomatic population the relaxation times varied only from approximately 45 to 55 ms (n = 8, age range 22-45 years).
Preliminary results demonstrated the in vivo feasibility of quantifying early biochemical changes in symptomatic osteoarthritis subjects employing T(1rho)-weighted MRI on a 1.5 T clinical scanner. This study on limited number of symptomatic population shows that T(1rho)-weighted MRI provides a noninvasive marker for quantitation of early degenerative changes of cartilage in vivo. However, further studies are needed to correlate early osteoarthritis determined from arthroscopy with T(1rho) in a large symptomatic population.</description><subject>Adult</subject><subject>Cartilage, Articular - pathology</subject><subject>Female</subject><subject>Femur - pathology</subject><subject>Humans</subject><subject>Knee Joint - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteoarthritis, Knee - diagnosis</subject><subject>Patella - pathology</subject><issn>1076-6332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Pg0AQhvegsbX6BzyYPXkD94NdwJupn0kTL72TYRkoDbC4C439Df5pIdazp5l38rzPYQi54SzkjOv7fQjGQSgYi0ImQ6b4GVlyFutASykW5NL7PWNc6URekAVXgscq5UvyLZ-CLXc7Gzhs4AuG2na0hb6vu4rakoIbajM24KiZ1wYqfKB1Rw_1wVLwHr1vsRtmFME1R1pghR26SXRAanbQVejngj-2_WDb6W6o9QPaSbdz9Rz9mO_RDP6KnJfQeLw-zRXZvjxv12_B5uP1ff24CfpE8QCLWBuIWCoEz1nCuIiw1CkTphSpMEIXMopynkpMI1nkMWo0pQGMkxiEinK5Ine_2t7ZzxH9kLW1N9g00KEdfaa1Vlyk-l9Q8lQopaIJvD2BY95ikfWubsEds783yx_Sl4Fm</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Regatte, Ravinder Reddy</creator><creator>Akella, Sarma V S</creator><creator>Wheaton, Andrew J</creator><creator>Lech, Gwen</creator><creator>Borthakur, Arijitt</creator><creator>Kneeland, J Bruce</creator><creator>Reddy, Ravinder</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>200407</creationdate><title>3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects</title><author>Regatte, Ravinder Reddy ; Akella, Sarma V S ; Wheaton, Andrew J ; Lech, Gwen ; Borthakur, Arijitt ; Kneeland, J Bruce ; Reddy, Ravinder</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p851-ed76ca409221b080124ef6902cf292c26d344b193e943db7e6ecfcae787a254b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Cartilage, Articular - pathology</topic><topic>Female</topic><topic>Femur - pathology</topic><topic>Humans</topic><topic>Knee Joint - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteoarthritis, Knee - diagnosis</topic><topic>Patella - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Regatte, Ravinder Reddy</creatorcontrib><creatorcontrib>Akella, Sarma V S</creatorcontrib><creatorcontrib>Wheaton, Andrew J</creatorcontrib><creatorcontrib>Lech, Gwen</creatorcontrib><creatorcontrib>Borthakur, Arijitt</creatorcontrib><creatorcontrib>Kneeland, J Bruce</creatorcontrib><creatorcontrib>Reddy, Ravinder</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Academic radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Regatte, Ravinder Reddy</au><au>Akella, Sarma V S</au><au>Wheaton, Andrew J</au><au>Lech, Gwen</au><au>Borthakur, Arijitt</au><au>Kneeland, J Bruce</au><au>Reddy, Ravinder</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects</atitle><jtitle>Academic radiology</jtitle><addtitle>Acad Radiol</addtitle><date>2004-07</date><risdate>2004</risdate><volume>11</volume><issue>7</issue><spage>741</spage><epage>749</epage><pages>741-749</pages><issn>1076-6332</issn><abstract>To determine the in vivo feasibility of quantifying early degenerative changes in patellofemoral joint of symptomatic human knee using spin-lattice relaxation time in the rotating frame (T(1rho)) magnetic resonance imaging (MRI).
All the MRI experiments were performed on a 1.5 T whole-body GE Signa clinical scanner using a custom built 15-cm diameter transmit-receive quadrature birdcage radiofrequency coil. The T(1rho)-prepared magnetization was imaged with a three-dimensional gradient-echo pulse sequence pre-encoded with a three-pulse cluster consisting of two hard 90 degrees pulses and a low power spin-lock pulse. Quantitative T(1rho) relaxation maps of asymptomatic (n = 8 males), and six symptomatic human volunteers (four men, two women) were computed using a appropriate signal expression.
All six symptomatic volunteers showed elevation in T(1rho) relaxation times when compared with asymptomatic subjects. In symptomatic population, the T(1rho) relaxation times varied from 63 +/- 4 ms to 95 +/- 12 ms (mean +/- standard deviation) depending on the degree of cartilage degeneration. The increase in T(1rho) of symptomatic population was statistically significant (n = 6, P <.002) when compared with corresponding asymptomatic population. However, in asymptomatic population the relaxation times varied only from approximately 45 to 55 ms (n = 8, age range 22-45 years).
Preliminary results demonstrated the in vivo feasibility of quantifying early biochemical changes in symptomatic osteoarthritis subjects employing T(1rho)-weighted MRI on a 1.5 T clinical scanner. This study on limited number of symptomatic population shows that T(1rho)-weighted MRI provides a noninvasive marker for quantitation of early degenerative changes of cartilage in vivo. However, further studies are needed to correlate early osteoarthritis determined from arthroscopy with T(1rho) in a large symptomatic population.</abstract><cop>United States</cop><pmid>15217591</pmid><doi>10.1016/j.acra.2004.03.051</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Cartilage, Articular - pathology Female Femur - pathology Humans Knee Joint - pathology Magnetic Resonance Imaging Male Middle Aged Osteoarthritis, Knee - diagnosis Patella - pathology |
| title | 3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects |
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