Both T and non-T cells with proliferating potentials are effective in inducing suppression of allograft responses by alloantigen-specific intravenous presensitization combined with suboptimal doses of 15-deoxyspergualin

In an MHC class I-disparate combination of mouse strains, a single intravenous injection of donor spleen cells combined with 10 suboptimal doses of 15-deoxyspergualin (DSG) administration was effective in inducing donor-specific suppression of cytotoxic T-lymphocyte (CTL) responses and prolonged sur...

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Veröffentlicht in:	Transplant immunology 2004-06, Vol.13 (1), p.25-32
Hauptverfasser:	Tahara, Hideo, Iwanami, Norimasa, Tabata, Nobutada, Matsumura, Haruo, Matsuura, Takeshi, Kurita, Takashi, Miyazawa, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	15-deoxysupergualin Animals Antigens, CD - analysis Antigens, CD - immunology Cell Proliferation - drug effects Cell Proliferation - radiation effects Cell Transplantation Donor-specific intravenous presensitization Graft Enhancement, Immunologic - methods Graft Rejection - immunology Guanidines - administration & dosage Guanidines - pharmacology Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacology Injections, Intravenous Isoantigens - immunology Mice Skin graft Skin Transplantation - immunology Spleen - cytology Spleen - drug effects Spleen - radiation effects T-Lymphocytes - transplantation T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Tolerance Transplantation Tolerance - immunology Veto cell
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