T cell avidity determines the level of CTL activation

To investigate the influence of avidity on T cell activation in vitro and in vivo, we analyzed T cells from St40 and St42 mice, which express the same transgenic TCR specificfor an E1a‐derived epitope of adenovirus type 5 with different expression levels and therefore different avidities. Splenocyte...

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Veröffentlicht in:	European Journal of Immunology 2004-07, Vol.34 (7), p.1798-1806
Hauptverfasser:	Hofmann, Matthias, Radsak, Markus, Rechtsteiner, Gerd, Wiemann, Katrin, Günder, Marc, Bien‐Gräter, Ursula, Offringa, Rienk, Toes, René E.M., Rammensee, Hans‐Georg, Schild, Hansjörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation level Adenoviridae - physiology Adenovirus Adoptive Transfer Affinity Animals Avidity Biomarkers - analysis Cell Division Cells, Cultured Cytokines - secretion Immunization Lymphocyte Activation - immunology Mice Mice, Transgenic Receptors, Antigen, T-Cell - metabolism Receptors, Interleukin-2 - immunology Spleen - cytology Spleen - immunology T cell T-Lymphocytes, Cytotoxic - cytology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism T-Lymphocytes, Cytotoxic - secretion
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