Disinhibition of the somatosensory cortex in cervical dystonia—decreased amplitudes of high-frequency oscillations
To determine whether patients with cervical dystonia have electrophysiological signs of disinhibition in the somatosensory cortex by recording high-frequency oscillations (HFOs) in somatosensory evoked potentials (SEPs). HFOs were recorded in 13 patients and 10 age-matched control subjects, and the...
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| Veröffentlicht in: | Clinical neurophysiology 2004-07, Vol.115 (7), p.1624-1630 |
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| container_title | Clinical neurophysiology |
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| creator | Inoue, Ken Hashimoto, Isao Shirai, Takushi Kawakami, Hideshi Miyachi, Takafumi Mimori, Yasuyo Matsumoto, Masayasu |
| description | To determine whether patients with cervical dystonia have electrophysiological signs of disinhibition in the somatosensory cortex by recording high-frequency oscillations (HFOs) in somatosensory evoked potentials (SEPs).
HFOs were recorded in 13 patients and 10 age-matched control subjects, and the data were analyzed statistically by paired comparison and by Pearson's correlation.
In patients with cervical dystonia, the early part of HFOs showed a significant decrease in amplitude, and the amplitude ratios of both early and late parts of HFOs/N20 potential were also significantly decreased. The amplitudes of HFOs and N20 potential were linearly correlated in the control subjects but not in dystonia patients.
Patients with cervical dystonia may suffer from a disturbance of inhibition in the sensory cortex. This disturbance is reflected by decreased HFO amplitude, representing decreased activities of inhibitory interneurons in area 3b. |
| doi_str_mv | 10.1016/j.clinph.2004.02.006 |
| format | Article |
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HFOs were recorded in 13 patients and 10 age-matched control subjects, and the data were analyzed statistically by paired comparison and by Pearson's correlation.
In patients with cervical dystonia, the early part of HFOs showed a significant decrease in amplitude, and the amplitude ratios of both early and late parts of HFOs/N20 potential were also significantly decreased. The amplitudes of HFOs and N20 potential were linearly correlated in the control subjects but not in dystonia patients.
Patients with cervical dystonia may suffer from a disturbance of inhibition in the sensory cortex. This disturbance is reflected by decreased HFO amplitude, representing decreased activities of inhibitory interneurons in area 3b.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2004.02.006</identifier><identifier>PMID: 15203063</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Case-Control Studies ; Cervical dystonia ; Diseases of striated muscles. Neuromuscular diseases ; Dominance, Cerebral ; Electrodiagnosis. Electric activity recording ; Evoked Potentials, Somatosensory ; Female ; High-frequency oscillations ; Humans ; Interneurons ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Muscarinic Antagonists - therapeutic use ; N20 potential ; Nervous system ; Neural Inhibition ; Neurology ; Oscillometry ; Reaction Time ; Somatosensory Cortex - physiopathology ; Somatosensory evoked potentials ; Torticollis - drug therapy ; Torticollis - physiopathology ; Trihexyphenidyl - therapeutic use</subject><ispartof>Clinical neurophysiology, 2004-07, Vol.115 (7), p.1624-1630</ispartof><rights>2004 International Federation of Clinical Neurophysiology</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-b48f8c98ccd9187924b952d76f83443c37f4b1b9a64ae3973381bed9d88f48d83</citedby><cites>FETCH-LOGICAL-c454t-b48f8c98ccd9187924b952d76f83443c37f4b1b9a64ae3973381bed9d88f48d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinph.2004.02.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15936284$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15203063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inoue, Ken</creatorcontrib><creatorcontrib>Hashimoto, Isao</creatorcontrib><creatorcontrib>Shirai, Takushi</creatorcontrib><creatorcontrib>Kawakami, Hideshi</creatorcontrib><creatorcontrib>Miyachi, Takafumi</creatorcontrib><creatorcontrib>Mimori, Yasuyo</creatorcontrib><creatorcontrib>Matsumoto, Masayasu</creatorcontrib><title>Disinhibition of the somatosensory cortex in cervical dystonia—decreased amplitudes of high-frequency oscillations</title><title>Clinical neurophysiology</title><addtitle>Clin Neurophysiol</addtitle><description>To determine whether patients with cervical dystonia have electrophysiological signs of disinhibition in the somatosensory cortex by recording high-frequency oscillations (HFOs) in somatosensory evoked potentials (SEPs).
HFOs were recorded in 13 patients and 10 age-matched control subjects, and the data were analyzed statistically by paired comparison and by Pearson's correlation.
In patients with cervical dystonia, the early part of HFOs showed a significant decrease in amplitude, and the amplitude ratios of both early and late parts of HFOs/N20 potential were also significantly decreased. The amplitudes of HFOs and N20 potential were linearly correlated in the control subjects but not in dystonia patients.
Patients with cervical dystonia may suffer from a disturbance of inhibition in the sensory cortex. This disturbance is reflected by decreased HFO amplitude, representing decreased activities of inhibitory interneurons in area 3b.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cervical dystonia</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Dominance, Cerebral</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Evoked Potentials, Somatosensory</subject><subject>Female</subject><subject>High-frequency oscillations</subject><subject>Humans</subject><subject>Interneurons</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscarinic Antagonists - therapeutic use</subject><subject>N20 potential</subject><subject>Nervous system</subject><subject>Neural Inhibition</subject><subject>Neurology</subject><subject>Oscillometry</subject><subject>Reaction Time</subject><subject>Somatosensory Cortex - physiopathology</subject><subject>Somatosensory evoked potentials</subject><subject>Torticollis - drug therapy</subject><subject>Torticollis - physiopathology</subject><subject>Trihexyphenidyl - therapeutic use</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAURiNERX_gDRDyBnZJHdvjOBskVCggVWIDa8uxb4hHiT34eqrOjofoE_ZJcDQjwYqV7-Lcz989VfW6pU1LW3m9bezsw25qGKWioayhVD6rLlrVsVr1G_a8zFypmolNd15dIm4ppR0V7EV13m4Y5VTyiyp_9OjD5AeffQwkjiRPQDAuJkeEgDEdiI0pwwPxgVhI996ambgD5hi8efr96MAmMAiOmGU3-7x3gGvO5H9O9Zjg1x6CPZCI1s-zWX_Bl9XZaGaEV6f3qvpx--n7zZf67tvnrzcf7morNiLXg1Cjsr2y1vXlrJ6JodzlOjkqLgS3vBvF0A69kcIA7zvOVTuA651So1BO8avq3TF3l2KpgVkvHi2UGgHiHrWUUkjVrqA4gjZFxASj3iW_mHTQLdWrbb3VR9t6ta0p08V2WXtzyt8PC7i_Sye9BXh7AgwWbWMywXr8h-u5ZEoU7v2Rg2Lj3kPSxVbRBs4nsFm76P_f5A8rO6NP</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>Inoue, Ken</creator><creator>Hashimoto, Isao</creator><creator>Shirai, Takushi</creator><creator>Kawakami, Hideshi</creator><creator>Miyachi, Takafumi</creator><creator>Mimori, Yasuyo</creator><creator>Matsumoto, Masayasu</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040701</creationdate><title>Disinhibition of the somatosensory cortex in cervical dystonia—decreased amplitudes of high-frequency oscillations</title><author>Inoue, Ken ; Hashimoto, Isao ; Shirai, Takushi ; Kawakami, Hideshi ; Miyachi, Takafumi ; Mimori, Yasuyo ; Matsumoto, Masayasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-b48f8c98ccd9187924b952d76f83443c37f4b1b9a64ae3973381bed9d88f48d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cervical dystonia</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Dominance, Cerebral</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Evoked Potentials, Somatosensory</topic><topic>Female</topic><topic>High-frequency oscillations</topic><topic>Humans</topic><topic>Interneurons</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscarinic Antagonists - therapeutic use</topic><topic>N20 potential</topic><topic>Nervous system</topic><topic>Neural Inhibition</topic><topic>Neurology</topic><topic>Oscillometry</topic><topic>Reaction Time</topic><topic>Somatosensory Cortex - physiopathology</topic><topic>Somatosensory evoked potentials</topic><topic>Torticollis - drug therapy</topic><topic>Torticollis - physiopathology</topic><topic>Trihexyphenidyl - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inoue, Ken</creatorcontrib><creatorcontrib>Hashimoto, Isao</creatorcontrib><creatorcontrib>Shirai, Takushi</creatorcontrib><creatorcontrib>Kawakami, Hideshi</creatorcontrib><creatorcontrib>Miyachi, Takafumi</creatorcontrib><creatorcontrib>Mimori, Yasuyo</creatorcontrib><creatorcontrib>Matsumoto, Masayasu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Ken</au><au>Hashimoto, Isao</au><au>Shirai, Takushi</au><au>Kawakami, Hideshi</au><au>Miyachi, Takafumi</au><au>Mimori, Yasuyo</au><au>Matsumoto, Masayasu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disinhibition of the somatosensory cortex in cervical dystonia—decreased amplitudes of high-frequency oscillations</atitle><jtitle>Clinical neurophysiology</jtitle><addtitle>Clin Neurophysiol</addtitle><date>2004-07-01</date><risdate>2004</risdate><volume>115</volume><issue>7</issue><spage>1624</spage><epage>1630</epage><pages>1624-1630</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>To determine whether patients with cervical dystonia have electrophysiological signs of disinhibition in the somatosensory cortex by recording high-frequency oscillations (HFOs) in somatosensory evoked potentials (SEPs).
HFOs were recorded in 13 patients and 10 age-matched control subjects, and the data were analyzed statistically by paired comparison and by Pearson's correlation.
In patients with cervical dystonia, the early part of HFOs showed a significant decrease in amplitude, and the amplitude ratios of both early and late parts of HFOs/N20 potential were also significantly decreased. The amplitudes of HFOs and N20 potential were linearly correlated in the control subjects but not in dystonia patients.
Patients with cervical dystonia may suffer from a disturbance of inhibition in the sensory cortex. This disturbance is reflected by decreased HFO amplitude, representing decreased activities of inhibitory interneurons in area 3b.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15203063</pmid><doi>10.1016/j.clinph.2004.02.006</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Case-Control Studies Cervical dystonia Diseases of striated muscles. Neuromuscular diseases Dominance, Cerebral Electrodiagnosis. Electric activity recording Evoked Potentials, Somatosensory Female High-frequency oscillations Humans Interneurons Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Muscarinic Antagonists - therapeutic use N20 potential Nervous system Neural Inhibition Neurology Oscillometry Reaction Time Somatosensory Cortex - physiopathology Somatosensory evoked potentials Torticollis - drug therapy Torticollis - physiopathology Trihexyphenidyl - therapeutic use |
| title | Disinhibition of the somatosensory cortex in cervical dystonia—decreased amplitudes of high-frequency oscillations |
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