Curcumin modulates free radical quenching in myocardial ischaemia in rats
This study was designed to investigate the protective effect of curcumin (CUR) against isoprenaline induced myocardial ischaemia in rat myocardium. The effect of single oral dose of curcumin (15 mg kg −1), administered 30 min before and/or after the onset of ischaemia, was investigated by assessing...
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| Veröffentlicht in: | The international journal of biochemistry & cell biology 2004-10, Vol.36 (10), p.1967-1980 |
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| container_end_page | 1980 |
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| container_issue | 10 |
| container_start_page | 1967 |
| container_title | The international journal of biochemistry & cell biology |
| container_volume | 36 |
| creator | Manikandan, Panchatcharam Sumitra, Miriyala Aishwarya, Srinivasan Manohar, Bhakthavatsalam Murali Lokanadam, Beema Puvanakrishnan, Rengarajulu |
| description | This study was designed to investigate the protective effect of curcumin (CUR) against isoprenaline induced myocardial ischaemia in rat myocardium. The effect of single oral dose of curcumin (15
mg
kg
−1), administered 30
min before and/or after the onset of ischaemia, was investigated by assessing oxidative stress related biochemical parameters in rat myocardium. Curcumin pre and post-treatment (PPT) was shown to decrease the levels of xanthine oxidase, superoxide anion, lipid peroxides (LPs) and myeloperoxidase while the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-
S-transferase (GST) activities were significantly increased after curcumin PPT. Histopathological and transmission electron microscopical studies also confirmed the severe myocardial damage occurring as a consequence of isoprenaline induced ischaemia and they also showed the significant improvement effected by curcumin PPT. These findings provided evidence that curcumin was found to protect rat myocardium against ischaemic insult and the protective effect could be attributed to its antioxidant properties as well as its inhibitory effects on xanthine dehydrogenase/xanthine oxidase (XD/XO) conversion and resultant superoxide anion production. |
| doi_str_mv | 10.1016/j.biocel.2004.01.030 |
| format | Article |
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mg
kg
−1), administered 30
min before and/or after the onset of ischaemia, was investigated by assessing oxidative stress related biochemical parameters in rat myocardium. Curcumin pre and post-treatment (PPT) was shown to decrease the levels of xanthine oxidase, superoxide anion, lipid peroxides (LPs) and myeloperoxidase while the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-
S-transferase (GST) activities were significantly increased after curcumin PPT. Histopathological and transmission electron microscopical studies also confirmed the severe myocardial damage occurring as a consequence of isoprenaline induced ischaemia and they also showed the significant improvement effected by curcumin PPT. These findings provided evidence that curcumin was found to protect rat myocardium against ischaemic insult and the protective effect could be attributed to its antioxidant properties as well as its inhibitory effects on xanthine dehydrogenase/xanthine oxidase (XD/XO) conversion and resultant superoxide anion production.</description><identifier>ISSN: 1357-2725</identifier><identifier>EISSN: 1878-5875</identifier><identifier>DOI: 10.1016/j.biocel.2004.01.030</identifier><identifier>PMID: 15203111</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Anticoagulants ; Blood Coagulation Tests ; Curcumin ; Curcumin - pharmacology ; Disease Models, Animal ; Female ; Free radicals ; Free Radicals - metabolism ; Hemodynamics - drug effects ; Lipid Peroxides - metabolism ; Molecular Structure ; Myocardial Ischemia - metabolism ; Myocardial Ischemia - pathology ; Myocardial Ischemia - physiopathology ; Oxidative stress ; Oxidative Stress - drug effects ; Plant Extracts - pharmacology ; Platelet Aggregation - drug effects ; Rats ; Rats, Wistar ; Superoxides - metabolism ; Thrombin - pharmacology</subject><ispartof>The international journal of biochemistry & cell biology, 2004-10, Vol.36 (10), p.1967-1980</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-d2459cdc85aadae6f3226b5b5c0be87d3bf9431776192a4ffe463d69b6a4a6d23</citedby><cites>FETCH-LOGICAL-c428t-d2459cdc85aadae6f3226b5b5c0be87d3bf9431776192a4ffe463d69b6a4a6d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biocel.2004.01.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15203111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manikandan, Panchatcharam</creatorcontrib><creatorcontrib>Sumitra, Miriyala</creatorcontrib><creatorcontrib>Aishwarya, Srinivasan</creatorcontrib><creatorcontrib>Manohar, Bhakthavatsalam Murali</creatorcontrib><creatorcontrib>Lokanadam, Beema</creatorcontrib><creatorcontrib>Puvanakrishnan, Rengarajulu</creatorcontrib><title>Curcumin modulates free radical quenching in myocardial ischaemia in rats</title><title>The international journal of biochemistry & cell biology</title><addtitle>Int J Biochem Cell Biol</addtitle><description>This study was designed to investigate the protective effect of curcumin (CUR) against isoprenaline induced myocardial ischaemia in rat myocardium. The effect of single oral dose of curcumin (15
mg
kg
−1), administered 30
min before and/or after the onset of ischaemia, was investigated by assessing oxidative stress related biochemical parameters in rat myocardium. Curcumin pre and post-treatment (PPT) was shown to decrease the levels of xanthine oxidase, superoxide anion, lipid peroxides (LPs) and myeloperoxidase while the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-
S-transferase (GST) activities were significantly increased after curcumin PPT. Histopathological and transmission electron microscopical studies also confirmed the severe myocardial damage occurring as a consequence of isoprenaline induced ischaemia and they also showed the significant improvement effected by curcumin PPT. These findings provided evidence that curcumin was found to protect rat myocardium against ischaemic insult and the protective effect could be attributed to its antioxidant properties as well as its inhibitory effects on xanthine dehydrogenase/xanthine oxidase (XD/XO) conversion and resultant superoxide anion production.</description><subject>Animals</subject><subject>Anticoagulants</subject><subject>Blood Coagulation Tests</subject><subject>Curcumin</subject><subject>Curcumin - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Free radicals</subject><subject>Free Radicals - metabolism</subject><subject>Hemodynamics - drug effects</subject><subject>Lipid Peroxides - metabolism</subject><subject>Molecular Structure</subject><subject>Myocardial Ischemia - metabolism</subject><subject>Myocardial Ischemia - pathology</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Platelet Aggregation - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxides - metabolism</subject><subject>Thrombin - pharmacology</subject><issn>1357-2725</issn><issn>1878-5875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtLwzAUgIMobk7_gUiffGvNve2LIMPLYOCLPoc0OXUZvcykFfbvTenANyFwwuE7tw-hW4Izgol82GeV6w00GcWYZ5hkmOEztCRFXqSiyMV5_DORpzSnYoGuQthjjImg7BItYsCMELJEm_Xozdi6Lml7OzZ6gJDUHiDx2jqjm-R7hM7sXPeVTMyxN9pbF_MumJ2G1ukp7_UQrtFFrZsAN6e4Qp8vzx_rt3T7_rpZP21Tw2kxpJZyURprCqG11SBrRqmsRCUMrqDILavqkjOS55KUVPO6Bi6ZlWUlNdfSUrZC93Pfg-_jcmFQbdwFmkZ30I9BSSl5fDiCfAaN70PwUKuDd632R0WwmhSqvZoVqkmhwkRFhbHs7tR_rFqwf0UnZxF4nAGIV_448CoYFyWBdR7MoGzv_p_wC6BshI8</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Manikandan, Panchatcharam</creator><creator>Sumitra, Miriyala</creator><creator>Aishwarya, Srinivasan</creator><creator>Manohar, Bhakthavatsalam Murali</creator><creator>Lokanadam, Beema</creator><creator>Puvanakrishnan, Rengarajulu</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Curcumin modulates free radical quenching in myocardial ischaemia in rats</title><author>Manikandan, Panchatcharam ; Sumitra, Miriyala ; Aishwarya, Srinivasan ; Manohar, Bhakthavatsalam Murali ; Lokanadam, Beema ; Puvanakrishnan, Rengarajulu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-d2459cdc85aadae6f3226b5b5c0be87d3bf9431776192a4ffe463d69b6a4a6d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Anticoagulants</topic><topic>Blood Coagulation Tests</topic><topic>Curcumin</topic><topic>Curcumin - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Free radicals</topic><topic>Free Radicals - metabolism</topic><topic>Hemodynamics - drug effects</topic><topic>Lipid Peroxides - metabolism</topic><topic>Molecular Structure</topic><topic>Myocardial Ischemia - metabolism</topic><topic>Myocardial Ischemia - pathology</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Platelet Aggregation - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Superoxides - metabolism</topic><topic>Thrombin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manikandan, Panchatcharam</creatorcontrib><creatorcontrib>Sumitra, Miriyala</creatorcontrib><creatorcontrib>Aishwarya, Srinivasan</creatorcontrib><creatorcontrib>Manohar, Bhakthavatsalam Murali</creatorcontrib><creatorcontrib>Lokanadam, Beema</creatorcontrib><creatorcontrib>Puvanakrishnan, Rengarajulu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of biochemistry & cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manikandan, Panchatcharam</au><au>Sumitra, Miriyala</au><au>Aishwarya, Srinivasan</au><au>Manohar, Bhakthavatsalam Murali</au><au>Lokanadam, Beema</au><au>Puvanakrishnan, Rengarajulu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curcumin modulates free radical quenching in myocardial ischaemia in rats</atitle><jtitle>The international journal of biochemistry & cell biology</jtitle><addtitle>Int J Biochem Cell Biol</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>36</volume><issue>10</issue><spage>1967</spage><epage>1980</epage><pages>1967-1980</pages><issn>1357-2725</issn><eissn>1878-5875</eissn><abstract>This study was designed to investigate the protective effect of curcumin (CUR) against isoprenaline induced myocardial ischaemia in rat myocardium. The effect of single oral dose of curcumin (15
mg
kg
−1), administered 30
min before and/or after the onset of ischaemia, was investigated by assessing oxidative stress related biochemical parameters in rat myocardium. Curcumin pre and post-treatment (PPT) was shown to decrease the levels of xanthine oxidase, superoxide anion, lipid peroxides (LPs) and myeloperoxidase while the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-
S-transferase (GST) activities were significantly increased after curcumin PPT. Histopathological and transmission electron microscopical studies also confirmed the severe myocardial damage occurring as a consequence of isoprenaline induced ischaemia and they also showed the significant improvement effected by curcumin PPT. These findings provided evidence that curcumin was found to protect rat myocardium against ischaemic insult and the protective effect could be attributed to its antioxidant properties as well as its inhibitory effects on xanthine dehydrogenase/xanthine oxidase (XD/XO) conversion and resultant superoxide anion production.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>15203111</pmid><doi>10.1016/j.biocel.2004.01.030</doi><tpages>14</tpages></addata></record> |
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| identifier | ISSN: 1357-2725 |
| ispartof | The international journal of biochemistry & cell biology, 2004-10, Vol.36 (10), p.1967-1980 |
| issn | 1357-2725 1878-5875 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anticoagulants Blood Coagulation Tests Curcumin Curcumin - pharmacology Disease Models, Animal Female Free radicals Free Radicals - metabolism Hemodynamics - drug effects Lipid Peroxides - metabolism Molecular Structure Myocardial Ischemia - metabolism Myocardial Ischemia - pathology Myocardial Ischemia - physiopathology Oxidative stress Oxidative Stress - drug effects Plant Extracts - pharmacology Platelet Aggregation - drug effects Rats Rats, Wistar Superoxides - metabolism Thrombin - pharmacology |
| title | Curcumin modulates free radical quenching in myocardial ischaemia in rats |
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