Flt-3 ligand as adjuvant for DNA vaccination augments immune responses but does not skew TH1 TH2 polarization

Since transfection of dendritic cells (DC) plays a key role in DNA vaccination, in vivo expansion of DC might be a tool to increase vaccine efficacy. We asked whether Fms-like tyrosine kinase-3 ligand (Flt-3L), a growth factor for DC, can be used as an adjuvant for DNA vaccination. Beta-galactosidas...

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Veröffentlicht in:	Gene therapy 2004-07, Vol.11 (13), p.1048-1056
Hauptverfasser:	WESTERMANN, J, NGUYEN-HOAI, T, MOLLWEIDE, A, RICHTER, G, SCHMETZER, O, KIM, H-J, BLANKENSTEIN, Th, DÖRKEN, B, PEZZUTTO, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies - blood Antigens Applied cell therapy and gene therapy beta-Galactosidase - genetics beta-Galactosidase - immunology Biological and medical sciences Biotechnology CD4 antigen CD40 antigen CD8 antigen CD80 antigen CD86 antigen Cell Division Cytokines Cytotoxicity Dendritic cells Dendritic Cells - immunology Deoxyribonucleic acid DNA DNA vaccines Enzyme-Linked Immunosorbent Assay - methods Female Flow Cytometry Fundamental and applied biological sciences. Psychology Gene therapy Health aspects Health. Pharmaceutical industry Immunoglobulin G Immunoglobulin G - immunology Immunohistochemistry Industrial applications and implications. Economical aspects Injections, Intramuscular Interferon-gamma - blood Ligands Lymphocytes T Medical sciences Membrane Proteins - administration & dosage Mice Mice, Inbred C57BL Phenotypes Physiological aspects Protein-tyrosine kinase Splenocytes T cells Th1 Cells - immunology Th2 Cells - immunology Transfection Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vaccination Vaccine efficacy Vaccines, DNA - administration & dosage β-Galactosidase
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