Gender difference in C-reactive protein concentrations in individuals with atherothrombotic risk factors and apparently healthy ones
Recent studies have shown that C-reactive proteins have a pathogenetic role in atherothrombosis and concentrations of these substances could be used as a marker for future vascular events. The objective of this study was to determine gender differences in highly sensitive C-reactive protein (hs-CRP)...
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| Veröffentlicht in: | Biomarkers 2004-01, Vol.9 (1), p.85-92 |
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| creator | Rogowski, Ori Zeltser, David Shapira, Itzhak Burke, Michael Zakut, Vera Mardi, Tamar Ben-Assayag, Einor Serov, Jack Rozenblat, Meirav Berliner, Shlomo |
| description | Recent studies have shown that C-reactive proteins have a pathogenetic role in atherothrombosis and concentrations of these substances could be used as a marker for future vascular events. The objective of this study was to determine gender differences in highly sensitive C-reactive protein (hs-CRP) in individuals with atherothrombotic risk factors and apparently healthy ones. We have presently matched 469 females and 469 males having the same age and body mass index (BMI). Of these, 210 men and 210 women had no atherothrombotic risk factors. In this group the hs-CRP concentrations were 1.6±3.4 mg l−1 in women and 1.0±2.7 mg l−1 in men (p |
| doi_str_mv | 10.1080/13547500410001670303 |
| format | Article |
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The objective of this study was to determine gender differences in highly sensitive C-reactive protein (hs-CRP) in individuals with atherothrombotic risk factors and apparently healthy ones. We have presently matched 469 females and 469 males having the same age and body mass index (BMI). Of these, 210 men and 210 women had no atherothrombotic risk factors. In this group the hs-CRP concentrations were 1.6±3.4 mg l−1 in women and 1.0±2.7 mg l−1 in men (p<0.0005). These values were 2.1±3.4 mg l−1 and 1.5±2.8 mg l−1, respectively, in the entire cohort (p<0.0005), which included also individuals with atherothrombotic risk factors. We conclude that significant gender differences exist in hs-CRP concentrations despite perfect matching for age and BMI. These differences should be reflected in guidelines that suggest hs-CRP cut-off points for the stratification of vascular risk.</description><identifier>ISSN: 0963-7486</identifier><identifier>ISSN: 1354-750X</identifier><identifier>EISSN: 1465-3478</identifier><identifier>EISSN: 1366-5804</identifier><identifier>DOI: 10.1080/13547500410001670303</identifier><identifier>PMID: 15204313</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Arteriosclerosis - blood ; Arteriosclerosis - pathology ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; biomarker ; Biomarkers ; Blood and lymphatic vessels ; Body Mass Index ; C-Reactive Protein - biosynthesis ; Cardiology. Vascular system ; Cohort Studies ; Female ; gender differences ; highly sensitive C-reactive protein ; Humans ; Male ; Medical sciences ; Obesity ; Risk Factors ; Sex Factors</subject><ispartof>Biomarkers, 2004-01, Vol.9 (1), p.85-92</ispartof><rights>2004 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2004</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-5b3e260a5d7d3fb9132a49b235c6594148354d9dcfc7f7bf649c5afdce81cea63</citedby><cites>FETCH-LOGICAL-c444t-5b3e260a5d7d3fb9132a49b235c6594148354d9dcfc7f7bf649c5afdce81cea63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/13547500410001670303$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/13547500410001670303$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61402</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15677885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15204313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rogowski, Ori</creatorcontrib><creatorcontrib>Zeltser, David</creatorcontrib><creatorcontrib>Shapira, Itzhak</creatorcontrib><creatorcontrib>Burke, Michael</creatorcontrib><creatorcontrib>Zakut, Vera</creatorcontrib><creatorcontrib>Mardi, Tamar</creatorcontrib><creatorcontrib>Ben-Assayag, Einor</creatorcontrib><creatorcontrib>Serov, Jack</creatorcontrib><creatorcontrib>Rozenblat, Meirav</creatorcontrib><creatorcontrib>Berliner, Shlomo</creatorcontrib><title>Gender difference in C-reactive protein concentrations in individuals with atherothrombotic risk factors and apparently healthy ones</title><title>Biomarkers</title><addtitle>Biomarkers</addtitle><description>Recent studies have shown that C-reactive proteins have a pathogenetic role in atherothrombosis and concentrations of these substances could be used as a marker for future vascular events. The objective of this study was to determine gender differences in highly sensitive C-reactive protein (hs-CRP) in individuals with atherothrombotic risk factors and apparently healthy ones. We have presently matched 469 females and 469 males having the same age and body mass index (BMI). Of these, 210 men and 210 women had no atherothrombotic risk factors. In this group the hs-CRP concentrations were 1.6±3.4 mg l−1 in women and 1.0±2.7 mg l−1 in men (p<0.0005). These values were 2.1±3.4 mg l−1 and 1.5±2.8 mg l−1, respectively, in the entire cohort (p<0.0005), which included also individuals with atherothrombotic risk factors. We conclude that significant gender differences exist in hs-CRP concentrations despite perfect matching for age and BMI. These differences should be reflected in guidelines that suggest hs-CRP cut-off points for the stratification of vascular risk.</description><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - pathology</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>biomarker</subject><subject>Biomarkers</subject><subject>Blood and lymphatic vessels</subject><subject>Body Mass Index</subject><subject>C-Reactive Protein - biosynthesis</subject><subject>Cardiology. Vascular system</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>gender differences</subject><subject>highly sensitive C-reactive protein</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Obesity</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><issn>0963-7486</issn><issn>1354-750X</issn><issn>1465-3478</issn><issn>1366-5804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM2KFDEURgtRnHb0DUSy0V1p0vmr2ijS6CgMuNF1cSu5oTJWJW2SmqH3PrhpukUF0VUgOd-Xe0_TPGX0JaMdfcW4FFpSKhillClNOeX3mg0TSrZc6O5-s6G94q0WnbpoHuV8c-Sk1g-bCya3VHDGN833KwwWE7HeOUwYDBIfyK5NCKb4WyT7FAvWKxPrWygJio8hHyEfrL_1doU5kztfJgJlwkpPKS5jLN6Q5PNX4mpRTJlAsAT2e6iflPlAJoS5TAcSA-bHzQNXW_DJ-bxsvrx_93n3ob3-dPVx9_a6NUKI0sqR41ZRkFZb7sae8S2IftxyaZTsBRNdVWJ7a5zRTo9Oid5IcNZgxwyC4pfNi1NvXerbirkMi88G5xkCxjUPSikhenkExQk0Keac0A375BdIh4HR4Wh_-Jv9Gnt27l_HBe2v0Fl3BZ6fAcgGZpcgGJ9_45TWXScr9-bE-eBiWuAuptkOBQ5zTD9D_D-jvP6j4aTbVPvDTVxTqJr_vcsPG8e2jg</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Rogowski, Ori</creator><creator>Zeltser, David</creator><creator>Shapira, Itzhak</creator><creator>Burke, Michael</creator><creator>Zakut, Vera</creator><creator>Mardi, Tamar</creator><creator>Ben-Assayag, Einor</creator><creator>Serov, Jack</creator><creator>Rozenblat, Meirav</creator><creator>Berliner, Shlomo</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>Gender difference in C-reactive protein concentrations in individuals with atherothrombotic risk factors and apparently healthy ones</title><author>Rogowski, Ori ; Zeltser, David ; Shapira, Itzhak ; Burke, Michael ; Zakut, Vera ; Mardi, Tamar ; Ben-Assayag, Einor ; Serov, Jack ; Rozenblat, Meirav ; Berliner, Shlomo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-5b3e260a5d7d3fb9132a49b235c6594148354d9dcfc7f7bf649c5afdce81cea63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - pathology</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>biomarker</topic><topic>Biomarkers</topic><topic>Blood and lymphatic vessels</topic><topic>Body Mass Index</topic><topic>C-Reactive Protein - biosynthesis</topic><topic>Cardiology. Vascular system</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>gender differences</topic><topic>highly sensitive C-reactive protein</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Obesity</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rogowski, Ori</creatorcontrib><creatorcontrib>Zeltser, David</creatorcontrib><creatorcontrib>Shapira, Itzhak</creatorcontrib><creatorcontrib>Burke, Michael</creatorcontrib><creatorcontrib>Zakut, Vera</creatorcontrib><creatorcontrib>Mardi, Tamar</creatorcontrib><creatorcontrib>Ben-Assayag, Einor</creatorcontrib><creatorcontrib>Serov, Jack</creatorcontrib><creatorcontrib>Rozenblat, Meirav</creatorcontrib><creatorcontrib>Berliner, Shlomo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rogowski, Ori</au><au>Zeltser, David</au><au>Shapira, Itzhak</au><au>Burke, Michael</au><au>Zakut, Vera</au><au>Mardi, Tamar</au><au>Ben-Assayag, Einor</au><au>Serov, Jack</au><au>Rozenblat, Meirav</au><au>Berliner, Shlomo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender difference in C-reactive protein concentrations in individuals with atherothrombotic risk factors and apparently healthy ones</atitle><jtitle>Biomarkers</jtitle><addtitle>Biomarkers</addtitle><date>2004-01</date><risdate>2004</risdate><volume>9</volume><issue>1</issue><spage>85</spage><epage>92</epage><pages>85-92</pages><issn>0963-7486</issn><issn>1354-750X</issn><eissn>1465-3478</eissn><eissn>1366-5804</eissn><abstract>Recent studies have shown that C-reactive proteins have a pathogenetic role in atherothrombosis and concentrations of these substances could be used as a marker for future vascular events. The objective of this study was to determine gender differences in highly sensitive C-reactive protein (hs-CRP) in individuals with atherothrombotic risk factors and apparently healthy ones. We have presently matched 469 females and 469 males having the same age and body mass index (BMI). Of these, 210 men and 210 women had no atherothrombotic risk factors. In this group the hs-CRP concentrations were 1.6±3.4 mg l−1 in women and 1.0±2.7 mg l−1 in men (p<0.0005). These values were 2.1±3.4 mg l−1 and 1.5±2.8 mg l−1, respectively, in the entire cohort (p<0.0005), which included also individuals with atherothrombotic risk factors. We conclude that significant gender differences exist in hs-CRP concentrations despite perfect matching for age and BMI. These differences should be reflected in guidelines that suggest hs-CRP cut-off points for the stratification of vascular risk.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>15204313</pmid><doi>10.1080/13547500410001670303</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biomarkers, 2004-01, Vol.9 (1), p.85-92 |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Arteriosclerosis - blood Arteriosclerosis - pathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences biomarker Biomarkers Blood and lymphatic vessels Body Mass Index C-Reactive Protein - biosynthesis Cardiology. Vascular system Cohort Studies Female gender differences highly sensitive C-reactive protein Humans Male Medical sciences Obesity Risk Factors Sex Factors |
| title | Gender difference in C-reactive protein concentrations in individuals with atherothrombotic risk factors and apparently healthy ones |
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