Meta-analysis on the effect of off-pump coronary bypass surgery
Objective: To assess the effect of conventional coronary artery bypass surgery (CABG) compared to the off-pump procedure (OPCAB). Methods: Based on randomised trials found in PubMed and Science Citation Index, an overall odds ratio and 95% confidence interval was calculated for the combined endpoint...
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| Veröffentlicht in: | European journal of cardio-thoracic surgery 2004-07, Vol.26 (1), p.81-84 |
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| container_title | European journal of cardio-thoracic surgery |
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| creator | van der Heijden, Geert J.M.G. Nathoe, Hendrik M. Jansen, Erik W.L. Grobbee, Diederick E. |
| description | Objective: To assess the effect of conventional coronary artery bypass surgery (CABG) compared to the off-pump procedure (OPCAB). Methods: Based on randomised trials found in PubMed and Science Citation Index, an overall odds ratio and 95% confidence interval was calculated for the combined endpoint of mortality, stroke and myocardial infarction. Results: The 18 randomised trials included 1584 patients (783 OPCAB, 801 CABG). The odds ratio was 0.73 (95% CI=0.26; 2.04) at 2-week post-surgery, 0.75 (0.39; 1.42) at 1-month post-surgery, 0.55 (0.28; 1.08) at 3-month post-surgery, and 0.66 (0.38; 1.15) at 1-year post-surgery. Conclusions: The outcome of this meta-analysis shows favourable results for OPCAB for the combined endpoint of mortality, stroke and myocardial infarction at short and long term follow-up. However, none of the risk reductions reach statistical significance at the conventional level. Based on our results OPCAB appears to be equivalent to CABG. |
| doi_str_mv | 10.1016/j.ejcts.2004.03.032 |
| format | Article |
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Methods: Based on randomised trials found in PubMed and Science Citation Index, an overall odds ratio and 95% confidence interval was calculated for the combined endpoint of mortality, stroke and myocardial infarction. Results: The 18 randomised trials included 1584 patients (783 OPCAB, 801 CABG). The odds ratio was 0.73 (95% CI=0.26; 2.04) at 2-week post-surgery, 0.75 (0.39; 1.42) at 1-month post-surgery, 0.55 (0.28; 1.08) at 3-month post-surgery, and 0.66 (0.38; 1.15) at 1-year post-surgery. Conclusions: The outcome of this meta-analysis shows favourable results for OPCAB for the combined endpoint of mortality, stroke and myocardial infarction at short and long term follow-up. However, none of the risk reductions reach statistical significance at the conventional level. Based on our results OPCAB appears to be equivalent to CABG.</description><identifier>ISSN: 1010-7940</identifier><identifier>EISSN: 1873-734X</identifier><identifier>DOI: 10.1016/j.ejcts.2004.03.032</identifier><identifier>PMID: 15200983</identifier><language>eng</language><publisher>Germany: Elsevier Science B.V</publisher><subject>Cardiopulmonary Bypass - adverse effects ; Coronary Artery Bypass - adverse effects ; Coronary Artery Bypass - methods ; Coronary Artery Bypass - mortality ; Humans ; Meta-analysis ; Myocardial Infarction - etiology ; Off-pump coronary bypass surgery ; Randomised trials ; Randomized Controlled Trials as Topic ; Stroke - etiology ; Treatment Outcome</subject><ispartof>European journal of cardio-thoracic surgery, 2004-07, Vol.26 (1), p.81-84</ispartof><rights>Elsevier B.V. 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15200983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Heijden, Geert J.M.G.</creatorcontrib><creatorcontrib>Nathoe, Hendrik M.</creatorcontrib><creatorcontrib>Jansen, Erik W.L.</creatorcontrib><creatorcontrib>Grobbee, Diederick E.</creatorcontrib><title>Meta-analysis on the effect of off-pump coronary bypass surgery</title><title>European journal of cardio-thoracic surgery</title><addtitle>Eur J Cardiothorac Surg</addtitle><addtitle>Eur J Cardiothorac Surg</addtitle><description>Objective: To assess the effect of conventional coronary artery bypass surgery (CABG) compared to the off-pump procedure (OPCAB). Methods: Based on randomised trials found in PubMed and Science Citation Index, an overall odds ratio and 95% confidence interval was calculated for the combined endpoint of mortality, stroke and myocardial infarction. Results: The 18 randomised trials included 1584 patients (783 OPCAB, 801 CABG). The odds ratio was 0.73 (95% CI=0.26; 2.04) at 2-week post-surgery, 0.75 (0.39; 1.42) at 1-month post-surgery, 0.55 (0.28; 1.08) at 3-month post-surgery, and 0.66 (0.38; 1.15) at 1-year post-surgery. Conclusions: The outcome of this meta-analysis shows favourable results for OPCAB for the combined endpoint of mortality, stroke and myocardial infarction at short and long term follow-up. However, none of the risk reductions reach statistical significance at the conventional level. Based on our results OPCAB appears to be equivalent to CABG.</description><subject>Cardiopulmonary Bypass - adverse effects</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Coronary Artery Bypass - methods</subject><subject>Coronary Artery Bypass - mortality</subject><subject>Humans</subject><subject>Meta-analysis</subject><subject>Myocardial Infarction - etiology</subject><subject>Off-pump coronary bypass surgery</subject><subject>Randomised trials</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Stroke - etiology</subject><subject>Treatment Outcome</subject><issn>1010-7940</issn><issn>1873-734X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUNFKwzAUDaK4Of0CQfrkW-pNk6bpk8jQTZjog2LxJaRt4lrbtTYt2L83c1PhwL1wzrnccxA6J-ATIPyq9HWZ9dYPAJgP1CE4QFMiIoojypJDtwMBHMUMJujE2hIAOA2iYzQhoTPFgk7R9YPuFVYbVY22sF6z8fq19rQxOuu9xjgY3A5162VN12xUN3rp2CprPTt077obT9GRUZXVZ_s5Qy93t8_zJV49Lu7nNyu8pkT0OA1SrnLDg1THxACljIZ5JnKVkwAEU4xBSFUcgqOBZjROGWO5ETyFUKQRoTN0ubvbds3noG0v68JmuqrURjeDlZxzxlx0J7zYC4e01rlsu6J2b8vfyE7g7wTN0P6zILedylL-dCq3nUqgDoEz4J2hsL3--rOo7kPyiEahXCZvcrF6EvEieZUJ_QaVHXdO</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>van der Heijden, Geert J.M.G.</creator><creator>Nathoe, Hendrik M.</creator><creator>Jansen, Erik W.L.</creator><creator>Grobbee, Diederick E.</creator><general>Elsevier Science B.V</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200407</creationdate><title>Meta-analysis on the effect of off-pump coronary bypass surgery</title><author>van der Heijden, Geert J.M.G. ; Nathoe, Hendrik M. ; Jansen, Erik W.L. ; Grobbee, Diederick E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h318t-b2b6adf62be91f033435dc8dad12084a44053a950e9103c39b444df86b058b713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Cardiopulmonary Bypass - adverse effects</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>Coronary Artery Bypass - methods</topic><topic>Coronary Artery Bypass - mortality</topic><topic>Humans</topic><topic>Meta-analysis</topic><topic>Myocardial Infarction - etiology</topic><topic>Off-pump coronary bypass surgery</topic><topic>Randomised trials</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Stroke - etiology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Heijden, Geert J.M.G.</creatorcontrib><creatorcontrib>Nathoe, Hendrik M.</creatorcontrib><creatorcontrib>Jansen, Erik W.L.</creatorcontrib><creatorcontrib>Grobbee, Diederick E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cardio-thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Heijden, Geert J.M.G.</au><au>Nathoe, Hendrik M.</au><au>Jansen, Erik W.L.</au><au>Grobbee, Diederick E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis on the effect of off-pump coronary bypass surgery</atitle><jtitle>European journal of cardio-thoracic surgery</jtitle><stitle>Eur J Cardiothorac Surg</stitle><addtitle>Eur J Cardiothorac Surg</addtitle><date>2004-07</date><risdate>2004</risdate><volume>26</volume><issue>1</issue><spage>81</spage><epage>84</epage><pages>81-84</pages><issn>1010-7940</issn><eissn>1873-734X</eissn><abstract>Objective: To assess the effect of conventional coronary artery bypass surgery (CABG) compared to the off-pump procedure (OPCAB). Methods: Based on randomised trials found in PubMed and Science Citation Index, an overall odds ratio and 95% confidence interval was calculated for the combined endpoint of mortality, stroke and myocardial infarction. Results: The 18 randomised trials included 1584 patients (783 OPCAB, 801 CABG). The odds ratio was 0.73 (95% CI=0.26; 2.04) at 2-week post-surgery, 0.75 (0.39; 1.42) at 1-month post-surgery, 0.55 (0.28; 1.08) at 3-month post-surgery, and 0.66 (0.38; 1.15) at 1-year post-surgery. Conclusions: The outcome of this meta-analysis shows favourable results for OPCAB for the combined endpoint of mortality, stroke and myocardial infarction at short and long term follow-up. However, none of the risk reductions reach statistical significance at the conventional level. Based on our results OPCAB appears to be equivalent to CABG.</abstract><cop>Germany</cop><pub>Elsevier Science B.V</pub><pmid>15200983</pmid><doi>10.1016/j.ejcts.2004.03.032</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Cardiopulmonary Bypass - adverse effects Coronary Artery Bypass - adverse effects Coronary Artery Bypass - methods Coronary Artery Bypass - mortality Humans Meta-analysis Myocardial Infarction - etiology Off-pump coronary bypass surgery Randomised trials Randomized Controlled Trials as Topic Stroke - etiology Treatment Outcome |
| title | Meta-analysis on the effect of off-pump coronary bypass surgery |
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