New insights into the pathological role of TNF-alpha in early cardiac dysfunction and subsequent heart failure after infarction in rats

A marked increase in plasma TNF-alpha has been described in patients with chronic heart failure (CHF). Nevertheless, little is known about the direct role of this cytokine early after myocardial infarction (MI) and its possible effects on the subsequent development of CHF. Wistar rats were subjected...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2004-07, Vol.287 (1), p.H340-H350
Hauptverfasser:	Berthonneche, C, Sulpice, T, Boucher, F, Gouraud, L, de Leiris, J, O'Connor, S E, Herbert, J-M, Janiak, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - pharmacology Blood Volume Cardiac Output, Low - etiology Heart - physiopathology Hemodynamics Immunohistochemistry Male Myocardial Infarction - complications Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Myocardium - metabolism Myocardium - pathology Rats Rats, Wistar Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor, Type II Tissue Distribution Tumor Necrosis Factor-alpha - metabolism Ventricular Function, Left
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