Alteration of Cell Surface Sialylation Regulates Antigen-Induced Naive CD8+ T Cell Responses

The strength of interactions with APC instructs naive T cells to undergo programmed expansion and differentiation, which is largely determined by the peptide affinity and dose as well as the duration of TCR ligation. Although, most ligands mediating these interactions are terminally sialylated, the...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of immunology (1950) 2004-07, Vol.173 (1), p.275-284
Hauptverfasser:	Pappu, Bhanu P, Shrikant, Protul A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - physiology Antigens, CD - analysis Antigens, Differentiation, T-Lymphocyte - analysis Apoptosis CD8-Positive T-Lymphocytes - immunology Fluoresceins - metabolism Interferon-gamma - biosynthesis Lectins, C-Type Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Transgenic N-Acetylneuraminic Acid - metabolism Succinimides - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!