Inflammatory Markers and Incident Mobility Limitation in the Elderly
Objectives: To examine the relationship between indicators of inflammation and the incidence of mobility limitation in older persons. Design: Prospective cohort study: the Health, Aging and Body Composition Study. Setting: Pittsburgh, Pennsylvania, and Memphis, Tennessee. Participants: A total of 2,...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2004-07, Vol.52 (7), p.1105-1113 |
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| creator | Penninx, Brenda W. J. H. Kritchevsky, Stephen B. Newman, Anne B. Nicklas, Barbara J. Simonsick, Eleanor M. Rubin, Susan Nevitt, Michael Visser, Marjolein Harris, Tamara Pahor, Marco |
| description | Objectives: To examine the relationship between indicators of inflammation and the incidence of mobility limitation in older persons.
Design: Prospective cohort study: the Health, Aging and Body Composition Study.
Setting: Pittsburgh, Pennsylvania, and Memphis, Tennessee.
Participants: A total of 2,979 men and women, aged 70 to 79, without mobility limitation at baseline.
Measurements: Serum levels of interleukin (IL)‐6, tumor necrosis factor alpha (TNFα), and C‐reactive protein (CRP) and soluble cytokine receptors (IL‐2sR, IL‐6sR, TNFsR1, TNFsR2) were measured. Mobility limitation was assessed and defined as reporting difficulty or inability to walk one‐quarter of a mile or to climb 10 steps during two consecutive semiannual assessments over 30 months.
Results: Of the 2,979 participants, 30.1% developed incident mobility limitation. After adjustment for confounders (demographics, prevalent conditions at baseline, body composition), the relative risk (RR) of incident mobility limitation per standard deviation (SD) increase was 1.19 (95% confidence interval (CI)=1.10–1.28) for IL‐6, 1.20 (95% CI=1.12–1.29) for TNFα, and 1.40 (95% CI=1.18–1.68) for CRP. The association between inflammation and incident mobility limitation was especially strong for the onset of more severe mobility limitation and when the levels of multiple inflammatory markers were high. When persons with baseline or incident cardiovascular disease events or persons who were hospitalized during study follow‐up were excluded, findings remained similar. In a subset (n=499), high levels of the soluble receptors IL2sR and TNFsR1 (per SD increase: RR=1.23 (95% CI=1.04–1.46) and RR=1.28 (95% CI=1.04–1.57), respectively) were also associated with incident mobility limitation.
Conclusion: Findings suggest that inflammation is prognostic for incident mobility limitation over 30 months, independent of cardiovascular disease events and incident severe illness. |
| doi_str_mv | 10.1111/j.1532-5415.2004.52308.x |
| format | Article |
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Design: Prospective cohort study: the Health, Aging and Body Composition Study.
Setting: Pittsburgh, Pennsylvania, and Memphis, Tennessee.
Participants: A total of 2,979 men and women, aged 70 to 79, without mobility limitation at baseline.
Measurements: Serum levels of interleukin (IL)‐6, tumor necrosis factor alpha (TNFα), and C‐reactive protein (CRP) and soluble cytokine receptors (IL‐2sR, IL‐6sR, TNFsR1, TNFsR2) were measured. Mobility limitation was assessed and defined as reporting difficulty or inability to walk one‐quarter of a mile or to climb 10 steps during two consecutive semiannual assessments over 30 months.
Results: Of the 2,979 participants, 30.1% developed incident mobility limitation. After adjustment for confounders (demographics, prevalent conditions at baseline, body composition), the relative risk (RR) of incident mobility limitation per standard deviation (SD) increase was 1.19 (95% confidence interval (CI)=1.10–1.28) for IL‐6, 1.20 (95% CI=1.12–1.29) for TNFα, and 1.40 (95% CI=1.18–1.68) for CRP. The association between inflammation and incident mobility limitation was especially strong for the onset of more severe mobility limitation and when the levels of multiple inflammatory markers were high. When persons with baseline or incident cardiovascular disease events or persons who were hospitalized during study follow‐up were excluded, findings remained similar. In a subset (n=499), high levels of the soluble receptors IL2sR and TNFsR1 (per SD increase: RR=1.23 (95% CI=1.04–1.46) and RR=1.28 (95% CI=1.04–1.57), respectively) were also associated with incident mobility limitation.
Conclusion: Findings suggest that inflammation is prognostic for incident mobility limitation over 30 months, independent of cardiovascular disease events and incident severe illness.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2004.52308.x</identifier><identifier>PMID: 15209648</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Inc</publisher><subject>Aged ; Analysis. Health state ; Biological and medical sciences ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Cardiovascular disease ; Cross-sectional studies ; CRP ; Cytokines ; Elderly people ; Epidemiology ; Female ; General aspects ; Humans ; IL-6 ; Immune system ; Inflammation ; Inflammation - blood ; Interleukin-6 - blood ; Limitations ; Male ; Medical sciences ; Mobility ; mobility limitation ; older ; Older people ; Pennsylvania ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Receptors, Cytokine - blood ; Serological markers ; Tennessee ; Tumor Necrosis Factor-alpha - metabolism ; USA ; Walking - physiology</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2004-07, Vol.52 (7), p.1105-1113</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Jul 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6398-b74a4e52842e672d74d70efb2a5a4e041116432c11f8de24001519ddd3b981f93</citedby><cites>FETCH-LOGICAL-c6398-b74a4e52842e672d74d70efb2a5a4e041116432c11f8de24001519ddd3b981f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1532-5415.2004.52308.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1532-5415.2004.52308.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,31000,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15956130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15209648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Penninx, Brenda W. J. H.</creatorcontrib><creatorcontrib>Kritchevsky, Stephen B.</creatorcontrib><creatorcontrib>Newman, Anne B.</creatorcontrib><creatorcontrib>Nicklas, Barbara J.</creatorcontrib><creatorcontrib>Simonsick, Eleanor M.</creatorcontrib><creatorcontrib>Rubin, Susan</creatorcontrib><creatorcontrib>Nevitt, Michael</creatorcontrib><creatorcontrib>Visser, Marjolein</creatorcontrib><creatorcontrib>Harris, Tamara</creatorcontrib><creatorcontrib>Pahor, Marco</creatorcontrib><title>Inflammatory Markers and Incident Mobility Limitation in the Elderly</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>Objectives: To examine the relationship between indicators of inflammation and the incidence of mobility limitation in older persons.
Design: Prospective cohort study: the Health, Aging and Body Composition Study.
Setting: Pittsburgh, Pennsylvania, and Memphis, Tennessee.
Participants: A total of 2,979 men and women, aged 70 to 79, without mobility limitation at baseline.
Measurements: Serum levels of interleukin (IL)‐6, tumor necrosis factor alpha (TNFα), and C‐reactive protein (CRP) and soluble cytokine receptors (IL‐2sR, IL‐6sR, TNFsR1, TNFsR2) were measured. Mobility limitation was assessed and defined as reporting difficulty or inability to walk one‐quarter of a mile or to climb 10 steps during two consecutive semiannual assessments over 30 months.
Results: Of the 2,979 participants, 30.1% developed incident mobility limitation. After adjustment for confounders (demographics, prevalent conditions at baseline, body composition), the relative risk (RR) of incident mobility limitation per standard deviation (SD) increase was 1.19 (95% confidence interval (CI)=1.10–1.28) for IL‐6, 1.20 (95% CI=1.12–1.29) for TNFα, and 1.40 (95% CI=1.18–1.68) for CRP. The association between inflammation and incident mobility limitation was especially strong for the onset of more severe mobility limitation and when the levels of multiple inflammatory markers were high. When persons with baseline or incident cardiovascular disease events or persons who were hospitalized during study follow‐up were excluded, findings remained similar. In a subset (n=499), high levels of the soluble receptors IL2sR and TNFsR1 (per SD increase: RR=1.23 (95% CI=1.04–1.46) and RR=1.28 (95% CI=1.04–1.57), respectively) were also associated with incident mobility limitation.
Conclusion: Findings suggest that inflammation is prognostic for incident mobility limitation over 30 months, independent of cardiovascular disease events and incident severe illness.</description><subject>Aged</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular disease</subject><subject>Cross-sectional studies</subject><subject>CRP</subject><subject>Cytokines</subject><subject>Elderly people</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>IL-6</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Interleukin-6 - blood</subject><subject>Limitations</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mobility</subject><subject>mobility limitation</subject><subject>older</subject><subject>Older people</subject><subject>Pennsylvania</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Receptors, Cytokine - blood</subject><subject>Serological markers</subject><subject>Tennessee</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>USA</subject><subject>Walking - physiology</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkl1rFDEUhoModq3-BRkEvZsxJ99zI8jarivbWrEieBMykwxmnY-azOLOvzfTXap4U3OTkDzn5RyeIJQBLiCt19sCOCU5Z8ALgjErOKFYFfsHaHH38BAtMMYkVwLYCXoS4xZjIFipx-gEOMGlYGqB3q37pjVdZ8YhTNmFCT9ciJnpbbbua29dP2YXQ-VbP07Zxnd-NKMf-sz32fjdZWetdaGdnqJHjWmje3bcT9GX87Pr5ft883G1Xr7d5LWgpcoryQxznChGnJDESmYldk1FDE_3mKXJBKOkBmiUdYSlfjmU1lpalQqakp6iV4fcmzD83Lk46s7H2rWt6d2wi1oIwYgAeS_IJWaccbgXBMmVYHIGX_wDbodd6NO0mgCmoixh7k8doDoMMQbX6JvgOxMmDVjP4vRWz3707EfP4vStOL1Ppc-P-buqc_ZP4dFUAl4eARNr0zbBJD_xL67kAihO3JsD98u3bvrvBvSH1efbYwrIDwE-jm5_F5B-hhaSSq6_Xq709aerb1ewPNeX9DeG_MBJ</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Penninx, Brenda W. J. H.</creator><creator>Kritchevsky, Stephen B.</creator><creator>Newman, Anne B.</creator><creator>Nicklas, Barbara J.</creator><creator>Simonsick, Eleanor M.</creator><creator>Rubin, Susan</creator><creator>Nevitt, Michael</creator><creator>Visser, Marjolein</creator><creator>Harris, Tamara</creator><creator>Pahor, Marco</creator><general>Blackwell Science Inc</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7TS</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>200407</creationdate><title>Inflammatory Markers and Incident Mobility Limitation in the Elderly</title><author>Penninx, Brenda W. J. H. ; Kritchevsky, Stephen B. ; Newman, Anne B. ; Nicklas, Barbara J. ; Simonsick, Eleanor M. ; Rubin, Susan ; Nevitt, Michael ; Visser, Marjolein ; Harris, Tamara ; Pahor, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6398-b74a4e52842e672d74d70efb2a5a4e041116432c11f8de24001519ddd3b981f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Analysis. Health state</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular disease</topic><topic>Cross-sectional studies</topic><topic>CRP</topic><topic>Cytokines</topic><topic>Elderly people</topic><topic>Epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>IL-6</topic><topic>Immune system</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Interleukin-6 - blood</topic><topic>Limitations</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mobility</topic><topic>mobility limitation</topic><topic>older</topic><topic>Older people</topic><topic>Pennsylvania</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Receptors, Cytokine - blood</topic><topic>Serological markers</topic><topic>Tennessee</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>USA</topic><topic>Walking - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Penninx, Brenda W. J. H.</creatorcontrib><creatorcontrib>Kritchevsky, Stephen B.</creatorcontrib><creatorcontrib>Newman, Anne B.</creatorcontrib><creatorcontrib>Nicklas, Barbara J.</creatorcontrib><creatorcontrib>Simonsick, Eleanor M.</creatorcontrib><creatorcontrib>Rubin, Susan</creatorcontrib><creatorcontrib>Nevitt, Michael</creatorcontrib><creatorcontrib>Visser, Marjolein</creatorcontrib><creatorcontrib>Harris, Tamara</creatorcontrib><creatorcontrib>Pahor, Marco</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Physical Education Index</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Penninx, Brenda W. J. H.</au><au>Kritchevsky, Stephen B.</au><au>Newman, Anne B.</au><au>Nicklas, Barbara J.</au><au>Simonsick, Eleanor M.</au><au>Rubin, Susan</au><au>Nevitt, Michael</au><au>Visser, Marjolein</au><au>Harris, Tamara</au><au>Pahor, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory Markers and Incident Mobility Limitation in the Elderly</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2004-07</date><risdate>2004</risdate><volume>52</volume><issue>7</issue><spage>1105</spage><epage>1113</epage><pages>1105-1113</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>Objectives: To examine the relationship between indicators of inflammation and the incidence of mobility limitation in older persons.
Design: Prospective cohort study: the Health, Aging and Body Composition Study.
Setting: Pittsburgh, Pennsylvania, and Memphis, Tennessee.
Participants: A total of 2,979 men and women, aged 70 to 79, without mobility limitation at baseline.
Measurements: Serum levels of interleukin (IL)‐6, tumor necrosis factor alpha (TNFα), and C‐reactive protein (CRP) and soluble cytokine receptors (IL‐2sR, IL‐6sR, TNFsR1, TNFsR2) were measured. Mobility limitation was assessed and defined as reporting difficulty or inability to walk one‐quarter of a mile or to climb 10 steps during two consecutive semiannual assessments over 30 months.
Results: Of the 2,979 participants, 30.1% developed incident mobility limitation. After adjustment for confounders (demographics, prevalent conditions at baseline, body composition), the relative risk (RR) of incident mobility limitation per standard deviation (SD) increase was 1.19 (95% confidence interval (CI)=1.10–1.28) for IL‐6, 1.20 (95% CI=1.12–1.29) for TNFα, and 1.40 (95% CI=1.18–1.68) for CRP. The association between inflammation and incident mobility limitation was especially strong for the onset of more severe mobility limitation and when the levels of multiple inflammatory markers were high. When persons with baseline or incident cardiovascular disease events or persons who were hospitalized during study follow‐up were excluded, findings remained similar. In a subset (n=499), high levels of the soluble receptors IL2sR and TNFsR1 (per SD increase: RR=1.23 (95% CI=1.04–1.46) and RR=1.28 (95% CI=1.04–1.57), respectively) were also associated with incident mobility limitation.
Conclusion: Findings suggest that inflammation is prognostic for incident mobility limitation over 30 months, independent of cardiovascular disease events and incident severe illness.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Inc</pub><pmid>15209648</pmid><doi>10.1111/j.1532-5415.2004.52308.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Analysis. Health state Biological and medical sciences Biomarkers - blood C-Reactive Protein - metabolism Cardiovascular disease Cross-sectional studies CRP Cytokines Elderly people Epidemiology Female General aspects Humans IL-6 Immune system Inflammation Inflammation - blood Interleukin-6 - blood Limitations Male Medical sciences Mobility mobility limitation older Older people Pennsylvania Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Receptors, Cytokine - blood Serological markers Tennessee Tumor Necrosis Factor-alpha - metabolism USA Walking - physiology |
| title | Inflammatory Markers and Incident Mobility Limitation in the Elderly |
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