Quinoxaline N, N-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. Structure-activity relationships

Quinoxaline derivatives presented good inhibitor activity of growth of Trypanosoma cruzi in in vitro assays. The 50% inhibitory doses were of the same order of that of Nifurtimox. Derivative 13, a quinoxaline N,N'-dioxide derivative, and the reduced derivatives 19 and 20 were the most cytotoxic...

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