Extracellular HMGB1 as a proinflammatory cytokine

High mobility group box-1 protein (HMGB1, formerly known as HMG-1), a highly conserved ubiquitous protein, has been for a long time described as a nuclear DNA-binding protein involved in nucleosome stabilization and gene transcription. Recent discoveries indicate that HMGB1 is released from activate...

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Veröffentlicht in:Journal of interferon & cytokine research 2004-06, Vol.24 (6), p.329-333
Hauptverfasser: Chen, Guoqian, Ward, Mary F, Sama, Andrew E, Wang, Haichao
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Sprache:eng
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