Dexamethasone induces human spinal ligament derived cells toward osteogenic differentiation

Ossification of spinal ligament is characterized by heterotopic bone formation in the spinal ligaments that are normally composed of fibrous tissues. The pathogenesis of ossification of spinal ligament has been suggested to be associated with osteogenic differentiation of the spinal ligament cells....

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Veröffentlicht in:	Journal of cellular biochemistry 2004-07, Vol.92 (4), p.715-722
Hauptverfasser:	Murata, Hidenori, Tanaka, Hiroshi, Taguchi, Toshihiko, Shiigi, Eiichi, Mizokami, Hiroshi, Sugiyama, Toshihiro, Kawai, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	1,25‐dihydroxyvitamin D3 25-dihydroxyvitamin D3 Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Anti-Inflammatory Agents - pharmacology Blotting, Northern Calcitriol - pharmacology Calcium Channel Agonists - pharmacology Cell Differentiation - drug effects Cells, Cultured Collagen - genetics Collagen - metabolism Collagen Type I dexamethasone Dexamethasone - pharmacology Extracellular Matrix - metabolism Humans Ligaments - drug effects Ligaments - metabolism ossification Ossification, Heterotopic - metabolism Ossification, Heterotopic - pathology osteoblastic differentiation Protein Precursors - genetics Protein Precursors - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Spinal Diseases - metabolism Spinal Diseases - pathology spinal ligament
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