Myopericytoma in Patients With AIDS: A New Class of Epstein-Barr Virus-associated Tumor
Myopericytoma is an uncommon, benign perivascular myoid cell tumor that occurs almost exclusively in somatic soft tissues. We report 2 cases occurring in patients with acquired immunodeficiency syndrome who show unusual clinical and biologic features. One patient presented with a bronchial mass and...
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| Veröffentlicht in: | The American journal of surgical pathology 2009-11, Vol.33 (11), p.1666-1672 |
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| container_title | The American journal of surgical pathology |
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| creator | LAU, Patrick P. L WONG, On-Kit LUI, Philip C. W CHEUNG, Oi-Yee HO, Luen-Cheung WONG, Wing-Cheuk TO, Ka-Fai CHAN, John K. C |
| description | Myopericytoma is an uncommon, benign perivascular myoid cell tumor that occurs almost exclusively in somatic soft tissues. We report 2 cases occurring in patients with acquired immunodeficiency syndrome who show unusual clinical and biologic features. One patient presented with a bronchial mass and the other developed mass lesions of the tongue, vocal cord, and brain. Histologically, oval to plump spindly tumor cells with uniform nuclei and scanty cytoplasm formed sheets or cuffs around gaping or narrow vascular spaces. Focally, these areas merged into fascicles of more elongated cells with eosinophilic cytoplasm. The tumor cells were immunoreactive for actin but not desmin, and showed uniform labeling for Epstein-Barr virus (EBV) encoded RNAs on in-situ hybridization. Both patients were alive 5 years after incomplete excision of the lesions. In conjunction with another case reported in the literature, myopericytoma occurring in acquired immunodeficiency syndrome patients exhibits several features distinct from sporadic myopericytoma: presentation in anatomic sites other than somatic soft tissues, frequent presence of multifocal disease, and association with EBV. This tumor type therefore also broadens the spectrum of neoplasms associated with EBV. |
| doi_str_mv | 10.1097/PAS.0b013e3181aec307 |
| format | Article |
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L ; WONG, On-Kit ; LUI, Philip C. W ; CHEUNG, Oi-Yee ; HO, Luen-Cheung ; WONG, Wing-Cheuk ; TO, Ka-Fai ; CHAN, John K. C</creator><creatorcontrib>LAU, Patrick P. L ; WONG, On-Kit ; LUI, Philip C. W ; CHEUNG, Oi-Yee ; HO, Luen-Cheung ; WONG, Wing-Cheuk ; TO, Ka-Fai ; CHAN, John K. C</creatorcontrib><description>Myopericytoma is an uncommon, benign perivascular myoid cell tumor that occurs almost exclusively in somatic soft tissues. We report 2 cases occurring in patients with acquired immunodeficiency syndrome who show unusual clinical and biologic features. One patient presented with a bronchial mass and the other developed mass lesions of the tongue, vocal cord, and brain. Histologically, oval to plump spindly tumor cells with uniform nuclei and scanty cytoplasm formed sheets or cuffs around gaping or narrow vascular spaces. Focally, these areas merged into fascicles of more elongated cells with eosinophilic cytoplasm. The tumor cells were immunoreactive for actin but not desmin, and showed uniform labeling for Epstein-Barr virus (EBV) encoded RNAs on in-situ hybridization. Both patients were alive 5 years after incomplete excision of the lesions. In conjunction with another case reported in the literature, myopericytoma occurring in acquired immunodeficiency syndrome patients exhibits several features distinct from sporadic myopericytoma: presentation in anatomic sites other than somatic soft tissues, frequent presence of multifocal disease, and association with EBV. This tumor type therefore also broadens the spectrum of neoplasms associated with EBV.</description><identifier>ISSN: 0147-5185</identifier><identifier>EISSN: 1532-0979</identifier><identifier>DOI: 10.1097/PAS.0b013e3181aec307</identifier><identifier>PMID: 19675451</identifier><identifier>CODEN: AJSPDX</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Acquired Immunodeficiency Syndrome - complications ; Acquired Immunodeficiency Syndrome - metabolism ; Acquired Immunodeficiency Syndrome - pathology ; Adult ; AIDS-Related Opportunistic Infections - metabolism ; AIDS-Related Opportunistic Infections - pathology ; AIDS-Related Opportunistic Infections - virology ; Biological and medical sciences ; Epstein-Barr Virus Infections - complications ; Epstein-Barr Virus Infections - pathology ; Female ; Hemangiopericytoma - metabolism ; Hemangiopericytoma - pathology ; Hemangiopericytoma - virology ; Herpesvirus 4, Human - genetics ; Herpesvirus 4, Human - isolation & purification ; Human viral diseases ; Humans ; Immunocompromised Host ; In Situ Hybridization ; Infectious diseases ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Ribosomal Proteins - metabolism ; RNA, Viral - genetics ; RNA-Binding Proteins - metabolism ; Soft Tissue Neoplasms - metabolism ; Soft Tissue Neoplasms - pathology ; Soft Tissue Neoplasms - virology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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W</creatorcontrib><creatorcontrib>CHEUNG, Oi-Yee</creatorcontrib><creatorcontrib>HO, Luen-Cheung</creatorcontrib><creatorcontrib>WONG, Wing-Cheuk</creatorcontrib><creatorcontrib>TO, Ka-Fai</creatorcontrib><creatorcontrib>CHAN, John K. C</creatorcontrib><title>Myopericytoma in Patients With AIDS: A New Class of Epstein-Barr Virus-associated Tumor</title><title>The American journal of surgical pathology</title><addtitle>Am J Surg Pathol</addtitle><description>Myopericytoma is an uncommon, benign perivascular myoid cell tumor that occurs almost exclusively in somatic soft tissues. We report 2 cases occurring in patients with acquired immunodeficiency syndrome who show unusual clinical and biologic features. One patient presented with a bronchial mass and the other developed mass lesions of the tongue, vocal cord, and brain. Histologically, oval to plump spindly tumor cells with uniform nuclei and scanty cytoplasm formed sheets or cuffs around gaping or narrow vascular spaces. Focally, these areas merged into fascicles of more elongated cells with eosinophilic cytoplasm. The tumor cells were immunoreactive for actin but not desmin, and showed uniform labeling for Epstein-Barr virus (EBV) encoded RNAs on in-situ hybridization. Both patients were alive 5 years after incomplete excision of the lesions. In conjunction with another case reported in the literature, myopericytoma occurring in acquired immunodeficiency syndrome patients exhibits several features distinct from sporadic myopericytoma: presentation in anatomic sites other than somatic soft tissues, frequent presence of multifocal disease, and association with EBV. This tumor type therefore also broadens the spectrum of neoplasms associated with EBV.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Acquired Immunodeficiency Syndrome - metabolism</subject><subject>Acquired Immunodeficiency Syndrome - pathology</subject><subject>Adult</subject><subject>AIDS-Related Opportunistic Infections - metabolism</subject><subject>AIDS-Related Opportunistic Infections - pathology</subject><subject>AIDS-Related Opportunistic Infections - virology</subject><subject>Biological and medical sciences</subject><subject>Epstein-Barr Virus Infections - complications</subject><subject>Epstein-Barr Virus Infections - pathology</subject><subject>Female</subject><subject>Hemangiopericytoma - metabolism</subject><subject>Hemangiopericytoma - pathology</subject><subject>Hemangiopericytoma - virology</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>In Situ Hybridization</subject><subject>Infectious diseases</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Ribosomal Proteins - metabolism</subject><subject>RNA, Viral - genetics</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>Soft Tissue Neoplasms - metabolism</subject><subject>Soft Tissue Neoplasms - pathology</subject><subject>Soft Tissue Neoplasms - virology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myopericytoma in Patients With AIDS: A New Class of Epstein-Barr Virus-associated Tumor</atitle><jtitle>The American journal of surgical pathology</jtitle><addtitle>Am J Surg Pathol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>33</volume><issue>11</issue><spage>1666</spage><epage>1672</epage><pages>1666-1672</pages><issn>0147-5185</issn><eissn>1532-0979</eissn><coden>AJSPDX</coden><abstract>Myopericytoma is an uncommon, benign perivascular myoid cell tumor that occurs almost exclusively in somatic soft tissues. We report 2 cases occurring in patients with acquired immunodeficiency syndrome who show unusual clinical and biologic features. One patient presented with a bronchial mass and the other developed mass lesions of the tongue, vocal cord, and brain. Histologically, oval to plump spindly tumor cells with uniform nuclei and scanty cytoplasm formed sheets or cuffs around gaping or narrow vascular spaces. Focally, these areas merged into fascicles of more elongated cells with eosinophilic cytoplasm. The tumor cells were immunoreactive for actin but not desmin, and showed uniform labeling for Epstein-Barr virus (EBV) encoded RNAs on in-situ hybridization. Both patients were alive 5 years after incomplete excision of the lesions. In conjunction with another case reported in the literature, myopericytoma occurring in acquired immunodeficiency syndrome patients exhibits several features distinct from sporadic myopericytoma: presentation in anatomic sites other than somatic soft tissues, frequent presence of multifocal disease, and association with EBV. This tumor type therefore also broadens the spectrum of neoplasms associated with EBV.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>19675451</pmid><doi>10.1097/PAS.0b013e3181aec307</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0147-5185 |
| ispartof | The American journal of surgical pathology, 2009-11, Vol.33 (11), p.1666-1672 |
| issn | 0147-5185 1532-0979 |
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| subjects | Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - metabolism Acquired Immunodeficiency Syndrome - pathology Adult AIDS-Related Opportunistic Infections - metabolism AIDS-Related Opportunistic Infections - pathology AIDS-Related Opportunistic Infections - virology Biological and medical sciences Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - pathology Female Hemangiopericytoma - metabolism Hemangiopericytoma - pathology Hemangiopericytoma - virology Herpesvirus 4, Human - genetics Herpesvirus 4, Human - isolation & purification Human viral diseases Humans Immunocompromised Host In Situ Hybridization Infectious diseases Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Ribosomal Proteins - metabolism RNA, Viral - genetics RNA-Binding Proteins - metabolism Soft Tissue Neoplasms - metabolism Soft Tissue Neoplasms - pathology Soft Tissue Neoplasms - virology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Myopericytoma in Patients With AIDS: A New Class of Epstein-Barr Virus-associated Tumor |
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