Current Perspectives on Akt Akt-ivation and Akt-ions

The serine/threonine kinase Akt is an effector of PI3K-generated phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] and is a principle mediator of growth factor-induced signal transduction. Akt is activated through phosphorylation by specific kinases, and its activity is reduced directly by ph...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2009-11, Vol.234 (11), p.1264-1270
Hauptverfasser:	Matheny, Ronald W., Adamo, Martin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Cell Survival Enzyme Activation Homeostasis Humans Isoenzymes - chemistry Isoenzymes - metabolism Proto-Oncogene Proteins c-akt - chemistry Proto-Oncogene Proteins c-akt - metabolism
Online-Zugang:	Volltext
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