Intracerebral cell transplantation therapy for murine GM1 gangliosidosis

Abstract We performed a cell transplantation study to treat the brain involvement in lysosomal storage diseases. We used acid β-galactosidase knock-out mice (BKO) from C57BL/6 as recipients. To minimize immune responses, we used cells derived from transgenic mice of C57BL/6 overexpressing the normal...

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Veröffentlicht in:	Brain & development (Tokyo. 1979) 2009-11, Vol.31 (10), p.717-724
Hauptverfasser:	Sawada, Tomo, Tanaka, Akemi, Higaki, Katsumi, Takamura, Ayumi, Nanba, Eiji, Seto, Toshiyuki, Maeda, Mitsuyo, Yamaguchi, Etsuko, Matsuda, Junichiro, Yamano, Tunekazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Galactosidase - genetics beta-Galactosidase - metabolism Blotting, Western Brain Tissue Transplantation Cell transplantation Cells, Cultured Cerebral Cortex - transplantation Fetal brain cell Fetal Tissue Transplantation Gangliosidosis, GM1 - genetics Gangliosidosis, GM1 - therapy GM1-gangliosidosis Humans Mesenchymal stem cell Mesenchymal Stem Cell Transplantation Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neurology
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