Allergen immunotherapy induces a suppressive memory response mediated by IL-10 in a mouse asthma model

Human studies have demonstrated that allergen immunotherapy induces memory suppressive responses and IL-10 production by allergen-specific T cells. Previously, we established a mouse model in which allergen immunotherapy was effective in the suppression of allergen-induced asthma manifestations. In...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2004-06, Vol.113 (6), p.1204-1210
Hauptverfasser:	Vissers, Joost L.M., van Esch, Betty C.A.M., Hofman, Gerard A., Kapsenberg, Martien L., Weller, Frank R., van Oosterhout, Antoon J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies allergy Animals Asthma Asthma - immunology Asthma - therapy Biological and medical sciences Bronchoalveolar Lavage Fluid - chemistry Cytokines Cytokines - biosynthesis Desensitization, Immunologic eosinophilia Experiments Fundamental and applied biological sciences. Psychology Fundamental immunology hyperresponsiveness IgE IL-10 Immune Tolerance Immunoglobulin E - blood Immunologic Memory Immunopathology immunotherapy Interleukin-10 - physiology Interleukin-5 - analysis Laboratory animals Lung - immunology Lymph Nodes - immunology Lymphocytes Male Medical sciences Mice Mice, Inbred BALB C Ovalbumin - immunology regulatory T cells Studies suppression T H2 lymphocytes
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