Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease

This study evaluated the effect of large-volume abdominal liposuction on metabolic risk factors for coronary heart disease in women with abdominal obesity. Liposuction altered neither insulin sensitivity nor the plasma concentrations of C-reactive protein, interleukin-6, tumor necrosis factor α, or adiponectin. There also was no significant effect on other risk factors for coronary heart disease. Liposuction altered neither insulin sensitivity nor the plasma concentrations of C-reactive protein. Abdominal obesity, manifested by increased waist circumference, increased abdominal subcutaneous fat, and increased visceral fat, is associated with insulin resistance and other metabolic risk factors for coronary heart disease. 1 Although both the abdominal subcutaneous fat mass and the visceral fat mass are associated with insulin resistance, 2 it is not known whether one or both of these fat depots are actually involved in the pathogenesis of insulin resistance or whether they are simply associated with the metabolic complications of obesity. Diet-induced weight loss improves the metabolic complications of abdominal obesity. However, successful long-term weight management is difficult to achieve, and the . . .