Periadventitial Adipose Tissue Plays a Critical Role in Vascular Remodeling
RATIONALE:Obesity is associated with a high incidence of cardiovascular complications. However, the molecular link between obesity and vascular disease is not fully understood. Most previous studies have focused on the association between cardiovascular disease and accumulation of visceral fat. Peri...
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| Veröffentlicht in: | Circulation research 2009-10, Vol.105 (9), p.906-911 |
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| container_title | Circulation research |
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| creator | Takaoka, Minoru Nagata, Daisuke Kihara, Shinji Shimomura, Iichiro Kimura, Yu Tabata, Yasuhiko Saito, Yoshihiko Nagai, Ryozo Sata, Masataka |
| description | RATIONALE:Obesity is associated with a high incidence of cardiovascular complications. However, the molecular link between obesity and vascular disease is not fully understood. Most previous studies have focused on the association between cardiovascular disease and accumulation of visceral fat. Periadventitial fat is distributed ubiquitously around arteries throughout the body.
OBJECTIVE:Here, we investigated the impact of obesity on inflammation in the periadventitial adipose tissue and on lesion formation after vascular injury.
METHODS AND RESULTS:High-fat, high-sucrose feeding induced inflammatory changes and decreased adiponectin expression in the periadventitial adipose tissue, which was associated with enhanced neointima formation after endovascular injury. Removal of periadventitial fat markedly enhanced neointima formation after injury, which was attenuated by transplantation of subcutaneous adipose tissue from mice fed on regular chow. Adiponectin-deficient mice showed markedly enhanced lesion formation, which was reversed by local delivery, but not systemic administration, of recombinant adiponectin to the periadventitial area. The conditioned medium from subcutaneous fat attenuated increased cell number of smooth muscle cells in response to platelet derived growth factor-BB.
CONCLUSIONS:Our findings suggest that periadventitial fat may protect against neointimal formation after angioplasty under physiological conditions and that inflammatory changes in the periadventitial fat may have a direct role in the pathogenesis of vascular disease accelerated by obesity. |
| doi_str_mv | 10.1161/CIRCRESAHA.109.199653 |
| format | Article |
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OBJECTIVE:Here, we investigated the impact of obesity on inflammation in the periadventitial adipose tissue and on lesion formation after vascular injury.
METHODS AND RESULTS:High-fat, high-sucrose feeding induced inflammatory changes and decreased adiponectin expression in the periadventitial adipose tissue, which was associated with enhanced neointima formation after endovascular injury. Removal of periadventitial fat markedly enhanced neointima formation after injury, which was attenuated by transplantation of subcutaneous adipose tissue from mice fed on regular chow. Adiponectin-deficient mice showed markedly enhanced lesion formation, which was reversed by local delivery, but not systemic administration, of recombinant adiponectin to the periadventitial area. The conditioned medium from subcutaneous fat attenuated increased cell number of smooth muscle cells in response to platelet derived growth factor-BB.
CONCLUSIONS:Our findings suggest that periadventitial fat may protect against neointimal formation after angioplasty under physiological conditions and that inflammatory changes in the periadventitial fat may have a direct role in the pathogenesis of vascular disease accelerated by obesity.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/CIRCRESAHA.109.199653</identifier><identifier>PMID: 19762682</identifier><identifier>CODEN: CIRUAL</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Adiponectin - administration & dosage ; Adiponectin - deficiency ; Adiponectin - genetics ; Adiponectin - metabolism ; Adipose Tissue - metabolism ; Adipose Tissue - pathology ; Adipose Tissue - transplantation ; AMP-Activated Protein Kinases - genetics ; AMP-Activated Protein Kinases - metabolism ; Animals ; Biological and medical sciences ; Cell Proliferation ; Cells, Cultured ; Connective Tissue - metabolism ; Connective Tissue - pathology ; Culture Media, Conditioned - metabolism ; Disease Models, Animal ; Femoral Artery - injuries ; Femoral Artery - metabolism ; Femoral Artery - pathology ; Fundamental and applied biological sciences. Psychology ; Green Fluorescent Proteins - genetics ; Hyperplasia ; Inflammation - etiology ; Inflammation - metabolism ; Inflammation - pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Muscle, Smooth, Vascular - metabolism ; Obesity - complications ; Obesity - metabolism ; Obesity - pathology ; Platelet-Derived Growth Factor - metabolism ; Proto-Oncogene Proteins c-sis ; Rats ; Recombinant Proteins - metabolism ; Tissue Culture Techniques ; Transduction, Genetic ; Tunica Intima - metabolism ; Tunica Intima - pathology ; Vascular Diseases - etiology ; Vascular Diseases - metabolism ; Vascular Diseases - pathology ; Vertebrates: cardiovascular system</subject><ispartof>Circulation research, 2009-10, Vol.105 (9), p.906-911</ispartof><rights>2009 American Heart Association, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6280-7c1e070c0df0da0b5793204c61d7a535d7874730a2ebad8b33b759d403c981673</citedby><cites>FETCH-LOGICAL-c6280-7c1e070c0df0da0b5793204c61d7a535d7874730a2ebad8b33b759d403c981673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22063257$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19762682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takaoka, Minoru</creatorcontrib><creatorcontrib>Nagata, Daisuke</creatorcontrib><creatorcontrib>Kihara, Shinji</creatorcontrib><creatorcontrib>Shimomura, Iichiro</creatorcontrib><creatorcontrib>Kimura, Yu</creatorcontrib><creatorcontrib>Tabata, Yasuhiko</creatorcontrib><creatorcontrib>Saito, Yoshihiko</creatorcontrib><creatorcontrib>Nagai, Ryozo</creatorcontrib><creatorcontrib>Sata, Masataka</creatorcontrib><title>Periadventitial Adipose Tissue Plays a Critical Role in Vascular Remodeling</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>RATIONALE:Obesity is associated with a high incidence of cardiovascular complications. However, the molecular link between obesity and vascular disease is not fully understood. Most previous studies have focused on the association between cardiovascular disease and accumulation of visceral fat. Periadventitial fat is distributed ubiquitously around arteries throughout the body.
OBJECTIVE:Here, we investigated the impact of obesity on inflammation in the periadventitial adipose tissue and on lesion formation after vascular injury.
METHODS AND RESULTS:High-fat, high-sucrose feeding induced inflammatory changes and decreased adiponectin expression in the periadventitial adipose tissue, which was associated with enhanced neointima formation after endovascular injury. Removal of periadventitial fat markedly enhanced neointima formation after injury, which was attenuated by transplantation of subcutaneous adipose tissue from mice fed on regular chow. Adiponectin-deficient mice showed markedly enhanced lesion formation, which was reversed by local delivery, but not systemic administration, of recombinant adiponectin to the periadventitial area. The conditioned medium from subcutaneous fat attenuated increased cell number of smooth muscle cells in response to platelet derived growth factor-BB.
CONCLUSIONS:Our findings suggest that periadventitial fat may protect against neointimal formation after angioplasty under physiological conditions and that inflammatory changes in the periadventitial fat may have a direct role in the pathogenesis of vascular disease accelerated by obesity.</description><subject>Adiponectin - administration & dosage</subject><subject>Adiponectin - deficiency</subject><subject>Adiponectin - genetics</subject><subject>Adiponectin - metabolism</subject><subject>Adipose Tissue - metabolism</subject><subject>Adipose Tissue - pathology</subject><subject>Adipose Tissue - transplantation</subject><subject>AMP-Activated Protein Kinases - genetics</subject><subject>AMP-Activated Protein Kinases - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Connective Tissue - metabolism</subject><subject>Connective Tissue - pathology</subject><subject>Culture Media, Conditioned - metabolism</subject><subject>Disease Models, Animal</subject><subject>Femoral Artery - injuries</subject><subject>Femoral Artery - metabolism</subject><subject>Femoral Artery - pathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Green Fluorescent Proteins - genetics</subject><subject>Hyperplasia</subject><subject>Inflammation - etiology</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Obesity - complications</subject><subject>Obesity - metabolism</subject><subject>Obesity - pathology</subject><subject>Platelet-Derived Growth Factor - metabolism</subject><subject>Proto-Oncogene Proteins c-sis</subject><subject>Rats</subject><subject>Recombinant Proteins - metabolism</subject><subject>Tissue Culture Techniques</subject><subject>Transduction, Genetic</subject><subject>Tunica Intima - metabolism</subject><subject>Tunica Intima - pathology</subject><subject>Vascular Diseases - etiology</subject><subject>Vascular Diseases - metabolism</subject><subject>Vascular Diseases - pathology</subject><subject>Vertebrates: cardiovascular system</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQQC0EokvhJ4BygVuWGTu24-MqKrSiEtVSuEaOPUsN3mSxE6r-e1ztip5GmnnzoTeMvUVYIyr82F1tu-3Ft83lZo1g1miMkuIZW6HkTd1Ijc_ZCgBMrYWAM_Yq518A2AhuXrIzNFpx1fIV-3JDKVj_l8Y5zMHGauPDYcpU3YacF6puon3Ila26VMqu1LdTpCqM1Q-b3RJtqra0nzzFMP58zV7sbMz05hTP2fdPF7fdZX399fNVt7muneIt1NohgQYHfgfewiC1ERwap9BrK4X0utWNFmA5Dda3gxCDlsY3IJxpUWlxzj4c5x7S9GehPPf7kB3FaEealtwrpYTUDRZQHkGXppwT7fpDCnubHnqE_tFi_2SxpEx_tFj63p0WLMOe_FPXSVsB3p-AYsHGXbKjC_k_xzkoweXjpc2Ru5_iTCn_jss9pf6ObJzv-vIeEIC85uVPCFxAXTII4h8op4mp</recordid><startdate>20091023</startdate><enddate>20091023</enddate><creator>Takaoka, Minoru</creator><creator>Nagata, Daisuke</creator><creator>Kihara, Shinji</creator><creator>Shimomura, Iichiro</creator><creator>Kimura, Yu</creator><creator>Tabata, Yasuhiko</creator><creator>Saito, Yoshihiko</creator><creator>Nagai, Ryozo</creator><creator>Sata, Masataka</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091023</creationdate><title>Periadventitial Adipose Tissue Plays a Critical Role in Vascular Remodeling</title><author>Takaoka, Minoru ; Nagata, Daisuke ; Kihara, Shinji ; Shimomura, Iichiro ; Kimura, Yu ; Tabata, Yasuhiko ; Saito, Yoshihiko ; Nagai, Ryozo ; Sata, Masataka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6280-7c1e070c0df0da0b5793204c61d7a535d7874730a2ebad8b33b759d403c981673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adiponectin - administration & dosage</topic><topic>Adiponectin - deficiency</topic><topic>Adiponectin - genetics</topic><topic>Adiponectin - metabolism</topic><topic>Adipose Tissue - metabolism</topic><topic>Adipose Tissue - pathology</topic><topic>Adipose Tissue - transplantation</topic><topic>AMP-Activated Protein Kinases - genetics</topic><topic>AMP-Activated Protein Kinases - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Connective Tissue - metabolism</topic><topic>Connective Tissue - pathology</topic><topic>Culture Media, Conditioned - metabolism</topic><topic>Disease Models, Animal</topic><topic>Femoral Artery - injuries</topic><topic>Femoral Artery - metabolism</topic><topic>Femoral Artery - pathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Green Fluorescent Proteins - genetics</topic><topic>Hyperplasia</topic><topic>Inflammation - etiology</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Obesity - complications</topic><topic>Obesity - metabolism</topic><topic>Obesity - pathology</topic><topic>Platelet-Derived Growth Factor - metabolism</topic><topic>Proto-Oncogene Proteins c-sis</topic><topic>Rats</topic><topic>Recombinant Proteins - metabolism</topic><topic>Tissue Culture Techniques</topic><topic>Transduction, Genetic</topic><topic>Tunica Intima - metabolism</topic><topic>Tunica Intima - pathology</topic><topic>Vascular Diseases - etiology</topic><topic>Vascular Diseases - metabolism</topic><topic>Vascular Diseases - pathology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takaoka, Minoru</creatorcontrib><creatorcontrib>Nagata, Daisuke</creatorcontrib><creatorcontrib>Kihara, Shinji</creatorcontrib><creatorcontrib>Shimomura, Iichiro</creatorcontrib><creatorcontrib>Kimura, Yu</creatorcontrib><creatorcontrib>Tabata, Yasuhiko</creatorcontrib><creatorcontrib>Saito, Yoshihiko</creatorcontrib><creatorcontrib>Nagai, Ryozo</creatorcontrib><creatorcontrib>Sata, Masataka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takaoka, Minoru</au><au>Nagata, Daisuke</au><au>Kihara, Shinji</au><au>Shimomura, Iichiro</au><au>Kimura, Yu</au><au>Tabata, Yasuhiko</au><au>Saito, Yoshihiko</au><au>Nagai, Ryozo</au><au>Sata, Masataka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periadventitial Adipose Tissue Plays a Critical Role in Vascular Remodeling</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>2009-10-23</date><risdate>2009</risdate><volume>105</volume><issue>9</issue><spage>906</spage><epage>911</epage><pages>906-911</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><coden>CIRUAL</coden><abstract>RATIONALE:Obesity is associated with a high incidence of cardiovascular complications. However, the molecular link between obesity and vascular disease is not fully understood. Most previous studies have focused on the association between cardiovascular disease and accumulation of visceral fat. Periadventitial fat is distributed ubiquitously around arteries throughout the body.
OBJECTIVE:Here, we investigated the impact of obesity on inflammation in the periadventitial adipose tissue and on lesion formation after vascular injury.
METHODS AND RESULTS:High-fat, high-sucrose feeding induced inflammatory changes and decreased adiponectin expression in the periadventitial adipose tissue, which was associated with enhanced neointima formation after endovascular injury. Removal of periadventitial fat markedly enhanced neointima formation after injury, which was attenuated by transplantation of subcutaneous adipose tissue from mice fed on regular chow. Adiponectin-deficient mice showed markedly enhanced lesion formation, which was reversed by local delivery, but not systemic administration, of recombinant adiponectin to the periadventitial area. The conditioned medium from subcutaneous fat attenuated increased cell number of smooth muscle cells in response to platelet derived growth factor-BB.
CONCLUSIONS:Our findings suggest that periadventitial fat may protect against neointimal formation after angioplasty under physiological conditions and that inflammatory changes in the periadventitial fat may have a direct role in the pathogenesis of vascular disease accelerated by obesity.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>19762682</pmid><doi>10.1161/CIRCRESAHA.109.199653</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Adiponectin - administration & dosage Adiponectin - deficiency Adiponectin - genetics Adiponectin - metabolism Adipose Tissue - metabolism Adipose Tissue - pathology Adipose Tissue - transplantation AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Biological and medical sciences Cell Proliferation Cells, Cultured Connective Tissue - metabolism Connective Tissue - pathology Culture Media, Conditioned - metabolism Disease Models, Animal Femoral Artery - injuries Femoral Artery - metabolism Femoral Artery - pathology Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins - genetics Hyperplasia Inflammation - etiology Inflammation - metabolism Inflammation - pathology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Muscle, Smooth, Vascular - metabolism Obesity - complications Obesity - metabolism Obesity - pathology Platelet-Derived Growth Factor - metabolism Proto-Oncogene Proteins c-sis Rats Recombinant Proteins - metabolism Tissue Culture Techniques Transduction, Genetic Tunica Intima - metabolism Tunica Intima - pathology Vascular Diseases - etiology Vascular Diseases - metabolism Vascular Diseases - pathology Vertebrates: cardiovascular system |
| title | Periadventitial Adipose Tissue Plays a Critical Role in Vascular Remodeling |
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