Identification and Characterization of Binding Sites on S100A7, a Participant in Cancer and Inflammation Pathways

S100A7 (psoriasin) is a member of the S100 family of signaling proteins. It is implicated in and considered a therapeutic target for inflammation and cancer, yet no small molecule ligands for S100A7 have been identified. To begin the development of specific small molecule inhibitors of S100A7 functi...

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Veröffentlicht in:	Biochemistry (Easton) 2009-11, Vol.48 (44), p.10591-10600
Hauptverfasser:	León, Rafael, Murray, Jill I, Cragg, Gina, Farnell, Benjamin, West, Nathan R, Pace, Tamara C. S, Watson, Peter H, Bohne, Cornelia, Boulanger, Martin J, Hof, Fraser
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Calorimetry Crystallography, X-Ray Fluorescence Humans Inflammation - metabolism Models, Molecular Neoplasms - metabolism Protein Conformation S100 Calcium Binding Protein A7 S100 Proteins - chemistry S100 Proteins - metabolism Two-Hybrid System Techniques
Online-Zugang:	Volltext
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