Peroxynitrite induces tyrosine residue modifications in synaptophysin C-terminal domain, affecting its interaction with src

Peroxynitrite is a potent oxidant that contributes to tissue damage in neurodegenerative disorders. We have previously reported that treatment of rat brain synaptosomes with peroxynitrite induced post-translational modifications in pre- and post-synaptic proteins and stimulated soluble N-ethylmaleim...

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Veröffentlicht in:	Journal of neurochemistry 2009-11, Vol.111 (3), p.859-869
Hauptverfasser:	Mallozzi, Cinzia, Ceccarini, Marina, Camerini, Serena, Macchia, Gianfranco, Crescenzi, Marco, Petrucci, Tamara Corinna, Di Stasi, Anna Maria Michela
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacid receptors (glycine, glutamate, gaba) Animals Biochemistry Biological and medical sciences Brain - ultrastructure Cell receptors Cell structures and functions Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fundamental and applied biological sciences. Psychology Male Mass Spectrometry - methods Medical sciences Molecular and cellular biology Neurological disorders Neurology nitrotyrosine Oxidation peroxynitrite Peroxynitrous Acid - pharmacology phosphotyrosine Protein Binding - drug effects Protein Processing, Post-Translational - drug effects Proteins Rats Rats, Sprague-Dawley Rodents Signal Transduction - drug effects src homology 2 domain src Homology Domains - genetics src Homology Domains - physiology src tyrosine kinase src-Family Kinases - metabolism synaptophysin Synaptophysin - chemistry Synaptophysin - metabolism Synaptosomes - drug effects Tyrosine - metabolism
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