A meta-analysis of antidepressant outcome studies that involved children and adolescents
A meta‐analysis was performed of available studies that document response to antidepressant medications in the pediatric population, based upon guidelines developed in a methodological review of adult antidepressant response (Greenberg, Borstein, Greenberg, & Fisher, 1992). The 27 studies access...
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| Veröffentlicht in: | Journal of clinical psychology 1995-05, Vol.51 (3), p.340-345 |
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| container_end_page | 345 |
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| container_issue | 3 |
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| container_title | Journal of clinical psychology |
| container_volume | 51 |
| creator | Thurber, Steve Ensign, John Punnett, Audrey F. Welter, Kelly |
| description | A meta‐analysis was performed of available studies that document response to antidepressant medications in the pediatric population, based upon guidelines developed in a methodological review of adult antidepressant response (Greenberg, Borstein, Greenberg, & Fisher, 1992). The 27 studies accessed through standard medical and psychological data bases were assessed against the following criteria: degree of blindness, placebo group design, rating issues, sample size, inclusion criteria, and other methodological issues. Serious methodological flaws emerged in all areas, as well as an inverse relationship between positive findings and the presence of adequate experimental controls. Recommendations are made for improvements in experimental methodology, and caution is urged in the absence of well‐controlled studies. |
| doi_str_mv | 10.1002/1097-4679(199505)51:3<340::AID-JCLP2270510304>3.0.CO;2-S |
| format | Article |
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The 27 studies accessed through standard medical and psychological data bases were assessed against the following criteria: degree of blindness, placebo group design, rating issues, sample size, inclusion criteria, and other methodological issues. Serious methodological flaws emerged in all areas, as well as an inverse relationship between positive findings and the presence of adequate experimental controls. Recommendations are made for improvements in experimental methodology, and caution is urged in the absence of well‐controlled studies.</description><identifier>ISSN: 0021-9762</identifier><identifier>EISSN: 1097-4679</identifier><identifier>DOI: 10.1002/1097-4679(199505)51:3<340::AID-JCLP2270510304>3.0.CO;2-S</identifier><identifier>PMID: 7560133</identifier><identifier>CODEN: JCPYAO</identifier><language>eng</language><publisher>Brandon: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Antidepressant drugs ; Antidepressants ; Antidepressive Agents - adverse effects ; Antidepressive Agents - therapeutic use ; Biological and medical sciences ; Child ; Child psychology ; Children ; Depressive Disorder - drug therapy ; Depressive Disorder - psychology ; Double-Blind Method ; Female ; Humans ; Male ; Medical sciences ; Meta-analysis ; Neuropharmacology ; Outcomes ; Personality Assessment ; Pharmacology. Drug treatments ; Psychiatric disorders ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Randomized Controlled Trials as Topic ; Studies ; Systematic review ; Teenagers ; Treatment ; Treatment Outcome</subject><ispartof>Journal of clinical psychology, 1995-05, Vol.51 (3), p.340-345</ispartof><rights>Copyright © 1995 Wiley Periodicals, Inc., A Wiley Company</rights><rights>1995 INIST-CNRS</rights><rights>Copyright Clinical Psychology Publishing Company, Incorporated May 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4194-6239accad57e2595fdaf684da288f77affbf0c8dd52fadf0f5b1ac22d7bafe273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1097-4679%28199505%2951%3A3%3C340%3A%3AAID-JCLP2270510304%3E3.0.CO%3B2-S$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1097-4679%28199505%2951%3A3%3C340%3A%3AAID-JCLP2270510304%3E3.0.CO%3B2-S$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,31000,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3577165$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7560133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thurber, Steve</creatorcontrib><creatorcontrib>Ensign, John</creatorcontrib><creatorcontrib>Punnett, Audrey F.</creatorcontrib><creatorcontrib>Welter, Kelly</creatorcontrib><title>A meta-analysis of antidepressant outcome studies that involved children and adolescents</title><title>Journal of clinical psychology</title><addtitle>J. Clin. Psychol</addtitle><description>A meta‐analysis was performed of available studies that document response to antidepressant medications in the pediatric population, based upon guidelines developed in a methodological review of adult antidepressant response (Greenberg, Borstein, Greenberg, & Fisher, 1992). The 27 studies accessed through standard medical and psychological data bases were assessed against the following criteria: degree of blindness, placebo group design, rating issues, sample size, inclusion criteria, and other methodological issues. Serious methodological flaws emerged in all areas, as well as an inverse relationship between positive findings and the presence of adequate experimental controls. Recommendations are made for improvements in experimental methodology, and caution is urged in the absence of well‐controlled studies.</description><subject>Adolescent</subject><subject>Antidepressant drugs</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - adverse effects</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child psychology</subject><subject>Children</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - psychology</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meta-analysis</subject><subject>Neuropharmacology</subject><subject>Outcomes</subject><subject>Personality Assessment</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatric disorders</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Teenagers</subject><subject>Treatment</subject><subject>Treatment Outcome</subject><issn>0021-9762</issn><issn>1097-4679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqVUV1v00AQtBCohMJPQLIQQuXBYe_O57MDqogMLUVRgxSgfVtt7kN1cezgswv591yUKBJ9QOLpTprZmd2ZKHrPYMwA-BsGhUrSTBUnrCgkyNeSTcQ7kcJkMr34kHwuZ184VyAZCEhPxRjG5fwtTxYPotFh9GE0ClIsKVTGH0dPvL8FgBSYPIqOlMyACTGKrqfxyvaUUEP1xlc-bl1MTV8Zu-6s9-Ebt0Ov25WNfT-Yyvq4v6E-rpq7tr6zJtY3VW0624QpE5Npa-u1bXr_NHrkqPb22f49jr6dffxafkpm8_OLcjpLdMqKNMm4KEhrMlJZLgvpDLksTw3xPHdKkXNLBzo3RnJHxoGTS0aac6OW5CxX4jh6tdNdd-3PwfoeV1XYoK6pse3gUaqcsyzbEl_cI962QxfO9shFlheSZRBI1zuS7lrvO-tw3VUr6jbIALfN4DZe3MaLu2ZQMhQYmkEMzeDfzQQEsJwjx0WQfr73H5Yraw7C-yoC_nKPk9dUu44aXfkDTUilWCYDTe9ov6rabv5jvX9udw8JLsnOpfK9_X1woe4HhiiVxKvLc4SrxRmk3y9Dfn8AEPTIFQ</recordid><startdate>199505</startdate><enddate>199505</enddate><creator>Thurber, Steve</creator><creator>Ensign, John</creator><creator>Punnett, Audrey F.</creator><creator>Welter, Kelly</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Periodicals Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope></search><sort><creationdate>199505</creationdate><title>A meta-analysis of antidepressant outcome studies that involved children and adolescents</title><author>Thurber, Steve ; Ensign, John ; Punnett, Audrey F. ; Welter, Kelly</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4194-6239accad57e2595fdaf684da288f77affbf0c8dd52fadf0f5b1ac22d7bafe273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>Antidepressant drugs</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - adverse effects</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child psychology</topic><topic>Children</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - psychology</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meta-analysis</topic><topic>Neuropharmacology</topic><topic>Outcomes</topic><topic>Personality Assessment</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatric disorders</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Studies</topic><topic>Systematic review</topic><topic>Teenagers</topic><topic>Treatment</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thurber, Steve</creatorcontrib><creatorcontrib>Ensign, John</creatorcontrib><creatorcontrib>Punnett, Audrey F.</creatorcontrib><creatorcontrib>Welter, Kelly</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Journal of clinical psychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thurber, Steve</au><au>Ensign, John</au><au>Punnett, Audrey F.</au><au>Welter, Kelly</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A meta-analysis of antidepressant outcome studies that involved children and adolescents</atitle><jtitle>Journal of clinical psychology</jtitle><addtitle>J. Clin. Psychol</addtitle><date>1995-05</date><risdate>1995</risdate><volume>51</volume><issue>3</issue><spage>340</spage><epage>345</epage><pages>340-345</pages><issn>0021-9762</issn><eissn>1097-4679</eissn><coden>JCPYAO</coden><abstract>A meta‐analysis was performed of available studies that document response to antidepressant medications in the pediatric population, based upon guidelines developed in a methodological review of adult antidepressant response (Greenberg, Borstein, Greenberg, & Fisher, 1992). The 27 studies accessed through standard medical and psychological data bases were assessed against the following criteria: degree of blindness, placebo group design, rating issues, sample size, inclusion criteria, and other methodological issues. Serious methodological flaws emerged in all areas, as well as an inverse relationship between positive findings and the presence of adequate experimental controls. Recommendations are made for improvements in experimental methodology, and caution is urged in the absence of well‐controlled studies.</abstract><cop>Brandon</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7560133</pmid><doi>10.1002/1097-4679(199505)51:3<340::AID-JCLP2270510304>3.0.CO;2-S</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Antidepressant drugs Antidepressants Antidepressive Agents - adverse effects Antidepressive Agents - therapeutic use Biological and medical sciences Child Child psychology Children Depressive Disorder - drug therapy Depressive Disorder - psychology Double-Blind Method Female Humans Male Medical sciences Meta-analysis Neuropharmacology Outcomes Personality Assessment Pharmacology. Drug treatments Psychiatric disorders Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Randomized Controlled Trials as Topic Studies Systematic review Teenagers Treatment Treatment Outcome |
| title | A meta-analysis of antidepressant outcome studies that involved children and adolescents |
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