Randomized, Placebo-Controlled Trial of Paroxetine Versus Imipramine in Depressed HIV-Positive Outpatients

OBJECTIVE: This study examined whether a selective serotonin reuptake inhibitor (paroxetine) had comparable efficacy but greater tolerability than a tricyclic antidepressant (imipramine) in depressed patients with HIV infection. METHOD: Seventy-five HIV-positive patients (45% of whom had AIDS) were...

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Veröffentlicht in:	The American journal of psychiatry 1998-03, Vol.155 (3), p.367-372
Hauptverfasser:	Elliott, Andrew J., Uldall, Karina K., Bergam, Karen, Russo, Joan, Claypoole, Keith, Roy-Byrne, Peter P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - epidemiology Acquired Immunodeficiency Syndrome - psychology Adult Ambulatory Care Antidepressants Biological and medical sciences Bipolar disorder Comorbidity Depression Depressive Disorder - diagnosis Depressive Disorder - drug therapy Depressive Disorder - epidemiology Female HIV HIV Infections - epidemiology HIV Infections - psychology Human immunodeficiency virus Humans Illnesses Imipramine Imipramine - adverse effects Imipramine - therapeutic use Infections Male Medical sciences Mental depression Neuropharmacology Paroxetine Paroxetine - adverse effects Paroxetine - therapeutic use Patient Dropouts Patients Pharmacology. Drug treatments Placebos Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Randomized controlled trials Response rates School dropout programs School dropouts Serotonin Uptake Inhibitors - adverse effects Serotonin Uptake Inhibitors - therapeutic use Treatment Outcome USA
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