Opioid reinforcement in heroin-dependent volunteers during outpatient buprenorphine maintenance
This study examined the reinforcing effects of hydromorphone (HYD) (0, 4, 8, and 16 mg/70 kg i.m.) in heroin-dependent outpatient volunteers maintained on buprenorphine (BUP) at doses of 2, 4, and 8 mg, each for 2 weeks. Following a week of maintenance at each dose, volunteers received injections of...
Gespeichert in:
| Veröffentlicht in: | Drug and alcohol dependence 1999-10, Vol.56 (3), p.191-203 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 203 |
|---|---|
| container_issue | 3 |
| container_start_page | 191 |
| container_title | Drug and alcohol dependence |
| container_volume | 56 |
| creator | Greenwald, Mark K. Johanson, Chris-Ellyn Schuster, Charles R. |
| description | This study examined the reinforcing effects of hydromorphone (HYD) (0, 4, 8, and 16 mg/70 kg i.m.) in heroin-dependent outpatient volunteers maintained on buprenorphine (BUP) at doses of 2, 4, and 8 mg, each for 2 weeks. Following a week of maintenance at each dose, volunteers received injections of one of the four HYD doses under double-blind conditions. Eight volunteers (abstainers) were heroin-free during HYD test weeks, whereas six volunteers remained heroin-positive (nonabstainers). Among abstainers, HYD had minimal reinforcing value, whereas in nonabstainers there were marked dose-related increases in HYD reinforcing value, which were not attenuated by increasing doses of BUP. A similar pattern was found for HYD subjective agonist effects. Heroin craving among nonabstainers was significantly higher compared with abstainers, and was reduced in a dose-related manner by HYD. Although BUP and HYD produced dose-related miosis, abstinence status had no differential effect. In summary, BUP effects on opioid reinforcement were consistent from outpatient setting (heroin abstinence) to laboratory setting (decreased HYD reinforcement), supporting the validity of this laboratory model. |
| doi_str_mv | 10.1016/S0376-8716(99)00032-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_57538253</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0376871699000320</els_id><sourcerecordid>57538253</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-48aad7221a52002c12334e28c194300cdd95b23657cde9d6382aaf69ac906ee83</originalsourceid><addsrcrecordid>eNqFkM1O3DAURq2qqDNM-wigLCoEi9BrO3HiVVWNgCIhsYCuLY99A64SO7WTkXh7PMyodNeVpevz3Z9DyAmFSwpUfHsA3oiybag4l_ICADgr4QNZ0raRJUAlPpLlX2RBjlP6nSEQEj6RBYWaSWB0SdT96IKzRUTnuxANDuinwvniGWNwvrQ4ore72jb0s58QYyrsHJ1_KsI8jXpyu8_NPEb0IY7PzmMxaJdJr73Bz-So033CL4d3RX5dXz2uf5Z39ze36x93pakYncqq1do2jFFdMwBmKOO8QtYaKisOYKyV9YZxUTfGorSCt0zrTkhtJAjElq_I2b7vGMOfGdOkBpcM9r32GOak6qbOmZpnsN6DJoaUInZqjG7Q8UVRUDuz6s2s2mlTUqo3swpy7vQwYN4MaP9J7VVm4OsB0Mnovov5fJfeOckFNCJj3_cYZhtbh1ElkxUatC6imZQN7j-bvALskZbC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>57538253</pqid></control><display><type>article</type><title>Opioid reinforcement in heroin-dependent volunteers during outpatient buprenorphine maintenance</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Greenwald, Mark K. ; Johanson, Chris-Ellyn ; Schuster, Charles R.</creator><creatorcontrib>Greenwald, Mark K. ; Johanson, Chris-Ellyn ; Schuster, Charles R.</creatorcontrib><description>This study examined the reinforcing effects of hydromorphone (HYD) (0, 4, 8, and 16 mg/70 kg i.m.) in heroin-dependent outpatient volunteers maintained on buprenorphine (BUP) at doses of 2, 4, and 8 mg, each for 2 weeks. Following a week of maintenance at each dose, volunteers received injections of one of the four HYD doses under double-blind conditions. Eight volunteers (abstainers) were heroin-free during HYD test weeks, whereas six volunteers remained heroin-positive (nonabstainers). Among abstainers, HYD had minimal reinforcing value, whereas in nonabstainers there were marked dose-related increases in HYD reinforcing value, which were not attenuated by increasing doses of BUP. A similar pattern was found for HYD subjective agonist effects. Heroin craving among nonabstainers was significantly higher compared with abstainers, and was reduced in a dose-related manner by HYD. Although BUP and HYD produced dose-related miosis, abstinence status had no differential effect. In summary, BUP effects on opioid reinforcement were consistent from outpatient setting (heroin abstinence) to laboratory setting (decreased HYD reinforcement), supporting the validity of this laboratory model.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/S0376-8716(99)00032-0</identifier><identifier>PMID: 10529021</identifier><identifier>CODEN: DADEDV</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Analysis of Variance ; Behavior, Addictive - drug therapy ; Behavior, Addictive - psychology ; Biological and medical sciences ; Buprenorphine ; Buprenorphine - therapeutic use ; Double-Blind Method ; Drug addictions ; Drug dependency ; Drug Synergism ; Female ; Heroin ; Heroin dependence ; Heroin Dependence - psychology ; Heroin Dependence - rehabilitation ; Heroin Dependence - urine ; Humans ; Hydromorphone ; Hydromorphone - administration & dosage ; Male ; Medical sciences ; Middle Aged ; Narcotic Antagonists - therapeutic use ; Narcotics - administration & dosage ; Opioids ; Outpatients - psychology ; Pupil - drug effects ; Reinforcement ; Reinforcement (Psychology) ; Surveys and Questionnaires ; Toxicology ; Treatment</subject><ispartof>Drug and alcohol dependence, 1999-10, Vol.56 (3), p.191-203</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-48aad7221a52002c12334e28c194300cdd95b23657cde9d6382aaf69ac906ee83</citedby><cites>FETCH-LOGICAL-c421t-48aad7221a52002c12334e28c194300cdd95b23657cde9d6382aaf69ac906ee83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0376871699000320$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30977,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1936076$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10529021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greenwald, Mark K.</creatorcontrib><creatorcontrib>Johanson, Chris-Ellyn</creatorcontrib><creatorcontrib>Schuster, Charles R.</creatorcontrib><title>Opioid reinforcement in heroin-dependent volunteers during outpatient buprenorphine maintenance</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>This study examined the reinforcing effects of hydromorphone (HYD) (0, 4, 8, and 16 mg/70 kg i.m.) in heroin-dependent outpatient volunteers maintained on buprenorphine (BUP) at doses of 2, 4, and 8 mg, each for 2 weeks. Following a week of maintenance at each dose, volunteers received injections of one of the four HYD doses under double-blind conditions. Eight volunteers (abstainers) were heroin-free during HYD test weeks, whereas six volunteers remained heroin-positive (nonabstainers). Among abstainers, HYD had minimal reinforcing value, whereas in nonabstainers there were marked dose-related increases in HYD reinforcing value, which were not attenuated by increasing doses of BUP. A similar pattern was found for HYD subjective agonist effects. Heroin craving among nonabstainers was significantly higher compared with abstainers, and was reduced in a dose-related manner by HYD. Although BUP and HYD produced dose-related miosis, abstinence status had no differential effect. In summary, BUP effects on opioid reinforcement were consistent from outpatient setting (heroin abstinence) to laboratory setting (decreased HYD reinforcement), supporting the validity of this laboratory model.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Behavior, Addictive - drug therapy</subject><subject>Behavior, Addictive - psychology</subject><subject>Biological and medical sciences</subject><subject>Buprenorphine</subject><subject>Buprenorphine - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Drug addictions</subject><subject>Drug dependency</subject><subject>Drug Synergism</subject><subject>Female</subject><subject>Heroin</subject><subject>Heroin dependence</subject><subject>Heroin Dependence - psychology</subject><subject>Heroin Dependence - rehabilitation</subject><subject>Heroin Dependence - urine</subject><subject>Humans</subject><subject>Hydromorphone</subject><subject>Hydromorphone - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Narcotic Antagonists - therapeutic use</subject><subject>Narcotics - administration & dosage</subject><subject>Opioids</subject><subject>Outpatients - psychology</subject><subject>Pupil - drug effects</subject><subject>Reinforcement</subject><subject>Reinforcement (Psychology)</subject><subject>Surveys and Questionnaires</subject><subject>Toxicology</subject><subject>Treatment</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkM1O3DAURq2qqDNM-wigLCoEi9BrO3HiVVWNgCIhsYCuLY99A64SO7WTkXh7PMyodNeVpevz3Z9DyAmFSwpUfHsA3oiybag4l_ICADgr4QNZ0raRJUAlPpLlX2RBjlP6nSEQEj6RBYWaSWB0SdT96IKzRUTnuxANDuinwvniGWNwvrQ4ore72jb0s58QYyrsHJ1_KsI8jXpyu8_NPEb0IY7PzmMxaJdJr73Bz-So033CL4d3RX5dXz2uf5Z39ze36x93pakYncqq1do2jFFdMwBmKOO8QtYaKisOYKyV9YZxUTfGorSCt0zrTkhtJAjElq_I2b7vGMOfGdOkBpcM9r32GOak6qbOmZpnsN6DJoaUInZqjG7Q8UVRUDuz6s2s2mlTUqo3swpy7vQwYN4MaP9J7VVm4OsB0Mnovov5fJfeOckFNCJj3_cYZhtbh1ElkxUatC6imZQN7j-bvALskZbC</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>Greenwald, Mark K.</creator><creator>Johanson, Chris-Ellyn</creator><creator>Schuster, Charles R.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope></search><sort><creationdate>19991001</creationdate><title>Opioid reinforcement in heroin-dependent volunteers during outpatient buprenorphine maintenance</title><author>Greenwald, Mark K. ; Johanson, Chris-Ellyn ; Schuster, Charles R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-48aad7221a52002c12334e28c194300cdd95b23657cde9d6382aaf69ac906ee83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Behavior, Addictive - drug therapy</topic><topic>Behavior, Addictive - psychology</topic><topic>Biological and medical sciences</topic><topic>Buprenorphine</topic><topic>Buprenorphine - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Drug addictions</topic><topic>Drug dependency</topic><topic>Drug Synergism</topic><topic>Female</topic><topic>Heroin</topic><topic>Heroin dependence</topic><topic>Heroin Dependence - psychology</topic><topic>Heroin Dependence - rehabilitation</topic><topic>Heroin Dependence - urine</topic><topic>Humans</topic><topic>Hydromorphone</topic><topic>Hydromorphone - administration & dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Narcotic Antagonists - therapeutic use</topic><topic>Narcotics - administration & dosage</topic><topic>Opioids</topic><topic>Outpatients - psychology</topic><topic>Pupil - drug effects</topic><topic>Reinforcement</topic><topic>Reinforcement (Psychology)</topic><topic>Surveys and Questionnaires</topic><topic>Toxicology</topic><topic>Treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greenwald, Mark K.</creatorcontrib><creatorcontrib>Johanson, Chris-Ellyn</creatorcontrib><creatorcontrib>Schuster, Charles R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Drug and alcohol dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greenwald, Mark K.</au><au>Johanson, Chris-Ellyn</au><au>Schuster, Charles R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opioid reinforcement in heroin-dependent volunteers during outpatient buprenorphine maintenance</atitle><jtitle>Drug and alcohol dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>56</volume><issue>3</issue><spage>191</spage><epage>203</epage><pages>191-203</pages><issn>0376-8716</issn><eissn>1879-0046</eissn><coden>DADEDV</coden><abstract>This study examined the reinforcing effects of hydromorphone (HYD) (0, 4, 8, and 16 mg/70 kg i.m.) in heroin-dependent outpatient volunteers maintained on buprenorphine (BUP) at doses of 2, 4, and 8 mg, each for 2 weeks. Following a week of maintenance at each dose, volunteers received injections of one of the four HYD doses under double-blind conditions. Eight volunteers (abstainers) were heroin-free during HYD test weeks, whereas six volunteers remained heroin-positive (nonabstainers). Among abstainers, HYD had minimal reinforcing value, whereas in nonabstainers there were marked dose-related increases in HYD reinforcing value, which were not attenuated by increasing doses of BUP. A similar pattern was found for HYD subjective agonist effects. Heroin craving among nonabstainers was significantly higher compared with abstainers, and was reduced in a dose-related manner by HYD. Although BUP and HYD produced dose-related miosis, abstinence status had no differential effect. In summary, BUP effects on opioid reinforcement were consistent from outpatient setting (heroin abstinence) to laboratory setting (decreased HYD reinforcement), supporting the validity of this laboratory model.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10529021</pmid><doi>10.1016/S0376-8716(99)00032-0</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0376-8716 |
| ispartof | Drug and alcohol dependence, 1999-10, Vol.56 (3), p.191-203 |
| issn | 0376-8716 1879-0046 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_57538253 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Analysis of Variance Behavior, Addictive - drug therapy Behavior, Addictive - psychology Biological and medical sciences Buprenorphine Buprenorphine - therapeutic use Double-Blind Method Drug addictions Drug dependency Drug Synergism Female Heroin Heroin dependence Heroin Dependence - psychology Heroin Dependence - rehabilitation Heroin Dependence - urine Humans Hydromorphone Hydromorphone - administration & dosage Male Medical sciences Middle Aged Narcotic Antagonists - therapeutic use Narcotics - administration & dosage Opioids Outpatients - psychology Pupil - drug effects Reinforcement Reinforcement (Psychology) Surveys and Questionnaires Toxicology Treatment |
| title | Opioid reinforcement in heroin-dependent volunteers during outpatient buprenorphine maintenance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T19%3A19%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Opioid%20reinforcement%20in%20heroin-dependent%20volunteers%20during%20outpatient%20buprenorphine%20maintenance&rft.jtitle=Drug%20and%20alcohol%20dependence&rft.au=Greenwald,%20Mark%20K.&rft.date=1999-10-01&rft.volume=56&rft.issue=3&rft.spage=191&rft.epage=203&rft.pages=191-203&rft.issn=0376-8716&rft.eissn=1879-0046&rft.coden=DADEDV&rft_id=info:doi/10.1016/S0376-8716(99)00032-0&rft_dat=%3Cproquest_cross%3E57538253%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=57538253&rft_id=info:pmid/10529021&rft_els_id=S0376871699000320&rfr_iscdi=true |